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Methicillin-resistant staphylococcus aureus (MRSA) is a bacterium that is evolving towards adaptive changes to certain antibiotics like methicillin, oxacillin, penicillin, and amoxicillin. It is a communicable and most rapidly spreading disease worldwide. It is reported that MRSA is becoming common among children in intensive care units. This disease comes under Emerging Infectious Disease (EID). In this paper, MRSA proteome screening is done and Drug/vaccine targets are proposed based on its essentiality to the pathogen and non-homology with human proteome. Targets validation is done so that its targeting must not affect human proteome and vital pathways. Those targets which has no structure, structure prediction and validation is done and important epitopes and ligands are proposed on suitable targets.