alexa
Reach Us +44-1625-708989
Molecular Investigation of Clinically Suspected Familial Mediterranean Fever Patients Using ARMS-PCR | OMICS International
ISSN: 2470-6965
Malaria Control & Elimination
Make the best use of Scientific Research and information from our 700+ peer reviewed, Open Access Journals that operates with the help of 50,000+ Editorial Board Members and esteemed reviewers and 1000+ Scientific associations in Medical, Clinical, Pharmaceutical, Engineering, Technology and Management Fields.
Meet Inspiring Speakers and Experts at our 3000+ Global Conferenceseries Events with over 600+ Conferences, 1200+ Symposiums and 1200+ Workshops on Medical, Pharma, Engineering, Science, Technology and Business
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Molecular Investigation of Clinically Suspected Familial Mediterranean Fever Patients Using ARMS-PCR

Visit for more related articles at Malaria Control & Elimination

Abstract

Objective: To investigate the distribution of three most common missense mutations-M680I, M694V and V726A in pyrin gene among clinically suspected Familial Mediterranean Fever (FMF) patients of northern side of the West Bank/ Palestine. Methods: Fifty one blood samples were collected from clinically suspected FMF patients from Jenin, Nablus and RamAllah governorates and evaluated for the missense mutation in pyrin gene using ARMS-PCR technique. Results: Among fifty one patients that were evaluated, 31(60.8%) were identified with the mutations M694V, V726A and M680I in descending order of their occurrences. The results of the other 20 were undetermined. Conclusion: Molecular diagnosis of FMF through simple ARMS-PCR method helps to confirm the clinical diagnosis of the disease that relies on signs, symptoms, ethnicity and family history and response to colchicines.

Select your language of interest to view the total content in your interested language
Post your comment

Share This Article

Article Usage

  • Total views: 11976
  • [From(publication date):
    December-2013 - Sep 15, 2019]
  • Breakdown by view type
  • HTML page views : 8210
  • PDF downloads : 3766
Top