alexa Mortality in Patients with Type 2 Diabetes: Impact of Age, Glycemic Control, and Renal Complications | Open Access Journals
ISSN: 2155-6156
Journal of Diabetes & Metabolism
Like us on:
Make the best use of Scientific Research and information from our 700+ peer reviewed, Open Access Journals that operates with the help of 50,000+ Editorial Board Members and esteemed reviewers and 1000+ Scientific associations in Medical, Clinical, Pharmaceutical, Engineering, Technology and Management Fields.
Meet Inspiring Speakers and Experts at our 3000+ Global Conferenceseries Events with over 600+ Conferences, 1200+ Symposiums and 1200+ Workshops on
Medical, Pharma, Engineering, Science, Technology and Business

Mortality in Patients with Type 2 Diabetes: Impact of Age, Glycemic Control, and Renal Complications

Leonardo Roever1* and Anaisa Silva Roerver Borges2

1Department of Clinical Research, Federal University of Uberlandia, Uberlandia, Brazil

2Master Institute of Education President Antonio Carlos - IMEPAC-Araguari, Brazil

Corresponding Author:
Leonardo Roever
Department of Clinical Research
Av. Para, 1720-Bairro Umuarama
Uberlandia-MG-CEP 38400-902, Brazil
Tel: +553488039878
E-mail: [email protected]

Received Date: November 10, 2015; Accepted Date: December 07, 2015; Published Date: December 30, 2015

Citation: Roever L, Borges ASR (2015) Mortality in Patients with Type 2 Diabetes: Impact of Age, Glycemic Control, and Renal Complications. J Diabetes Metab 7:e119. doi:10.4172/2155-6156.1000e119

Copyright: © 2015 Roever L, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Visit for more related articles at Journal of Diabetes & Metabolism

Introduction

Diabetes mellitus is a chronic degenerative metabolic disease with worldwide prevalence approaching 400 million people. In patients with type 2 diabetes, hypertension, metabolic syndrome, low circulating testosterone levels, isolated fasting hyperglycemia and obesity paradox is associated with a range of adverse outcomes including cardiovascular disease and premature mortality [1-7].

Tancredi and colleagues assessed these risks according to glycemic control and renal complications among persons with type 2 diabetes. The authors included patients with type 2 diabetes who were registered in the Swedish National Diabetes Register. For each patient, five controls were randomly selected from the general population and matched according to age, sex, and county. The mean follow-up was 4.6 years in the diabetes group and 4.8 years in the control group. Overall, 77,117 of 435,369 patients with diabetes (17.7%) died, as compared with 306,097 of 2,117,483 controls (14.5%) (Adjusted hazard ratio (HR), 1.15; 95% confidence interval [CI], 1.14 to 1.16). The rate of cardiovascular death was 7.9% among patients versus 6.1% among controls (adjusted HR, 1.14; 95% CI, 1.13 to 1.15). The excess risks of death from any cause and cardiovascular death increased with younger age, worse glycemic control, and greater severity of renal complications. When compared with controls, the HR for death from any cause among patients younger than 55 years of age who had a glycated hemoglobin level of 6.9% or less (≤ 52 mmol per mole of nonglycated hemoglobin) was 1.92 (95% CI, 1.75 to 2.11); the corresponding HR among patients 75 years of age or older was 0.95 (95% CI, 0.94 to 0.96). Among patients with normoalbuminuria, the hazard ratio for death among those younger than 55 years of age with a glycated hemoglobin level of 6.9% or less, as compared with controls, was 1.60 (95% CI, 1.40 to 1.82); the corresponding HR among patients 75 years of age or older was 0.76 (95% CI, 0.75 to 0.78), and patients 65 to 74 years of age also had a significantly lower risk of death (HR, 0.87; 95% CI, 0.84 to 0.91) [8].

Mortality among persons with type 2 diabetes depending on age, glycemic control, and renal complications. A large cohort study should be conducted to definitively determine the clinical significance of these factors, its correlation with mortality. Potential treatments such as lifestyle modification, ectopic fat reduction, surgery and medications should be investigated.

References

Select your language of interest to view the total content in your interested language
Post your comment

Share This Article

Relevant Topics

Article Usage

  • Total views: 8022
  • [From(publication date):
    January-2016 - Nov 19, 2017]
  • Breakdown by view type
  • HTML page views : 7946
  • PDF downloads : 76
 

Post your comment

captcha   Reload  Can't read the image? click here to refresh

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords