alexa
Reach Us +44-1477412632
Multiple Myeloma with Prominent Auer Body Formation in Granulocytes | OMICS International
ISSN: 2165-7831
Journal of Blood & Lymph
Make the best use of Scientific Research and information from our 700+ peer reviewed, Open Access Journals that operates with the help of 50,000+ Editorial Board Members and esteemed reviewers and 1000+ Scientific associations in Medical, Clinical, Pharmaceutical, Engineering, Technology and Management Fields.
Meet Inspiring Speakers and Experts at our 3000+ Global Conferenceseries Events with over 600+ Conferences, 1200+ Symposiums and 1200+ Workshops on Medical, Pharma, Engineering, Science, Technology and Business
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Multiple Myeloma with Prominent Auer Body Formation in Granulocytes

Junichiro Takano, Takako Kitahara, Shotaro Hagiwara* and Akiyoshi Miwa

Division of Hematology, Internal Medicine, National Center for Global Health and Medicine, Tokyo, Japan

*Corresponding Author:
Shotaro Hagiwara
Division of Hematology, Internal Medicine
National Center for Global Health and Medicine
Tokyo, Japan
Tel:+81-3-3202-7181
E-mail: [email protected]

Received date: date October 28, 2014; Accepted date: date November 03, 2014; Published date: date November 05, 2014

Citation: Hagiwara S (2016) Multiple Myeloma with Prominent Auer Body Formation in Granulocytes . J Blood Lymph 4:i101. doi:10.4172/2165-7831.1000i101

Copyright: © 2014 Shotaro Hagiwara, This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Visit for more related articles at Journal of Blood & Lymph

Keywords

Multiple myeloma; Cytogenetics; Auer body formation in granulocytes; Thrombocytopenia

Clinical Image

A 57-year-old man with IgG, ISS stage II multiple myeloma with normal cytogenetics was treated with vincristine/adriamycin/ dexamethasone induction followed by autologous hematopoietic stem cell transplantation and achieved a very good partial response. The patient relapsed 4.5 years later and received bortezomib/ dexamethasone treatment, which conferred a very good partial response once again. After 3 years, his M protein level showed a rapid increase to 7.9 g/dl for a month. He also developed anemia, thrombocytopenia (white blood cell count, 5600/l; hemoglobin, 7.3 g/dl; platelet count, 9000/l), acute kidney injury, and acute liver failure. Relapse of multiple myeloma was confirmed by bone marrow biopsy, which showed 55.8% clonal plasma cells with complex karyotype abnormality including addition of 1q21, and fluorescence in situ hybridization revealed deletion of p53. Notably, neutrophils harboring prominent Auer rods were found in his bone marrow. Several pseudo- Pelger-Huet anomaly cells were observed, however myeloblasts were only 0.5%; there was no myeloblast with Auer rods. Also mild dyserythropoiesis and few abnormal megakaryocytes were observed (Figure 1).

blood-lymph-Myeloma-cell

Figure 1: Myeloma cell and neutrophil with prominent Auer rods.

Although the mechanism of Auer rod formation in this case is uncertain, myeloma-related damage of the bone marrow microenvironment or dysregulation of hematopoietic stem cells may have played a role [1].

References

Select your language of interest to view the total content in your interested language
Post your comment

Share This Article

Relevant Topics

Article Usage

  • Total views: 12693
  • [From(publication date):
    December-2014 - Oct 23, 2019]
  • Breakdown by view type
  • HTML page views : 8887
  • PDF downloads : 3806
Top