Need To Act Hastily against the Gastric Cancer Pathogen Helicobacter Pylori
Received Date: Apr 02, 2018 / Accepted Date: Apr 05, 2018 / Published Date: Apr 12, 2018
Helicobacter pylorus is one of the most prevalent gastric pathogens and colonizes 50% of the global population. Robin Warren and Barry J. Marshall discovered the gastric pathogen H. pylori from gastric biopsy samples and their discovery was awarded the Nobel Prize in Physiology or Medicine in 2005. H. pylori colonize the stomach and can cause the gastric mucosal inflammatory process termed “gastritis.” The discovery of H. pylori challenged the prevailing view concerning peptic ulcer etiology. H. pylorus is the only bacterium known for its common cause of bacterial-induced cancer. As a result, understanding the association of H. pylori with gastric cancer is a significant issue warranting further studies . It is no wonder the bacterium was classified as a Class II carcinogen, since the risk ratio of gastric cancer with H. pylori infection was 5.8% compared to the healthy stomach individual  and high prevalence of H. pylori association reporting in East Asia . The reason why the bacterium induces gastric cancer is due to the oncogenic protein Cag A synthesized and injected to host epithelium by the type IV secretion system, which plays a major role in H. pylori induced gastric cancer . Notably, H. pylori eradication decreased the risk of developing gastric cancer in H. pylori-infected patients . Bismuth quadruple therapy has been shown to be a successful eradication therapy in patients in the clarithromycin resistance geographical region or patients on a 14-day course of triple therapy which typically contain two antibiotics such as clarithromycin and amoxicillin with one proton pump inhibitor (PPI)  considering a successful medication for H. pylori. Individuals from low socio-economic backgrounds are more prone to developing this disease and are also highly prone for disease recurrence after an eradication therapy . The world is facing an emerging serious and potent threat as a result of antibiotic resistance and H. pylori (clarithromycin resistant H. pylori) is one of the culprits on the list of serious threats announced by the World Health Organization (WHO) and Center for Disease Control (CDC) . The pretreatment resistance is also an emerging problem in managing H. pylori and its treatment . The point mutation occurred in the 23s rRNA gene drives clarithromycin resistance . One of the main reason for increasing resistance to clarithromycin is due to the consumption of macrolides antibiotics previously and the occurrence of clarithromycin resistance in children is also due to intake of uncontrolled macrolides for respiratory tract illness . Hence, the development of novel drugs targeting H. pylori and its drug resistant strains, with anti-bacterial and anti-cancer activity for the treatment of H. pylori and its role in gastric cancer is imperative. High-throughput screening (HTS) is a valuable and cost-effective process to discover novel antimicrobials  and very few HTS studies are reported to discover molecules against H. pylori. One such pilot-HTS study reported that the anthelmintic molecule niclosamide can be repurposed against H. pylori . HTS can be an effective component of studies to discover novel and potential molecules to combat H. pylori infection, H. pylori drug resistance, and H. pylori infection that leads to gastric cancer given the risks posed by antibiotic resistance.
- Cover TL (2016) Helicobacter pylori diversity and gastric cancer risk. MBio 7: e01869-01815.
- Vohlonen I (2016) Risk of gastric cancer in Helicobacter pylori infection in a 15-year follow-up. Scand J Gastroenterol 51: 1159-1164.
- De Martel C, Forman D, Plummer M (2013) Gastric cancer: epidemiology and risk factors. Gastroenterol Clin North Am 42: 219-240.
- Hatakeyama M (2014) Helicobacter pylori CagA and gastric cancer: a paradigm for hit-and-run carcinogenesis. Cell Host Microbe 15: 306-316.
- Doorakkers E, Lagergren J, Engstrand L, Brusselaers N (2018) Helicobacter pylori eradication treatment and the risk of gastric adenocarcinoma in a Western population. Gut gutjnl 315363.
- Zagari RM, Rabitti S, Eusebi LH, Bazzoli F (2017) Treatment of helicobacter pylori infection: A clinical practice update. Eur J Clin Invest 48.
- Eusebi LH, Zagari RM, Bazzoli F (2014) Epidemiology of Helicobacter pylori infection. Helicobacter 1: 1-5.
- Centers for Disease Control and Prevention (2016) Antibiotic/Antimicrobial Resistance Biggest Threats.
- Osato MS (2001) Pattern of primary resistance of Helicobacter pylori to metronidazole or clarithromycin in the United States. Arch Intern Med 161: 1217-1220.
- Versalovic J (1996) Mutations in 23S rRNA are associated with clarithromycin resistance in Helicobacter pylori. Antimicrob Agents Chemother 40: 477-480.
- Megraud FH (2004) pylori antibiotic resistance: prevalence, importance, and advances in testing. Gut 53: 1374-1384.
- Rajamuthiah R (2014) Whole animal automated platform for drug discovery against multi-drug resistant Staphylococcus aureus. PloS one 9: e89189.
- Tharmalingam N, Port J, Castillo D, Mylonakis E (2018) Repurposing the anthelmintic drug niclosamide to combat Helicobacter pylori. Sci Rep 8: 3701.
Citation: Tharmalingam N (2018) Need To Act Hastily against the Gastric Cancer Pathogen Helicobacter Pylori. J Infect Dis Preve Med 6:e124. DOI: 10.4172/2329-8731.1000e124
Copyright: © 2018 Tharmalingam N. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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