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Endocrinology & Metabolic Syndrome
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Negative Urinary Fractionated Metanephrines and Elevated Urinary Vanillylmandelic Acid in a Patient with a Sympathetic Paravesical Paraganglioma

Lisseth Fernanda Marín Carrillo1* and Edwin Antonio Wandurraga Sánchez2

1 Centro Médico Carlos Ardila Lulle, Carrera 24 # 154-106, Urbanización El Bosque, Torre B Módulo 55 consultorio 806, Floridablanca, Santander, Colombia

2Deparment of Endocrinology and Molecular Oncology, Universidad Autónoma de Bucaramanga UNAB Campus El Bosque, Calle 157 # 14 – 55 Floridablanca, Santander, Colombia

corresponding Author:
Lisseth Fernanda Marín Carrillo
Centro Médico Carlos Ardila Lulle
Carrera 24 # 154-106
Urbanización El Bosque. Torre B Módulo 55 consultorio 806
Floridablanca, Santander, Colombia
Tel: +57689303, +573188481025
E-mail: [email protected]

Received Date: January 06, 2015; Accepted Date: January 07, 2015; Published Date: January 9, 2015

Citation: Carrillo LFM (2014) Negative Urinary Fractionated Metanephrines and Elevated Urinary Vanillylmandelic Acid in a Patient with a Sympathetic Paravesical Paraganglioma. Endocrinol Metab Synd 4:i004. doi:10.4172/2161-1017.1000i004

Copyright: © 2015 Carrillo LFM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Clinical Image

endocrinology-metabolic-syndrome-Urinary-Fractionated

Figure 1: Negative Urinary Fractionated Metanephrines and Elevated Urinary Vanillylmandelic Acid in a Patient with a Sympathetic Paravesical Paraganglioma.

Keywords

Paraganglioma; Positron-emission tomography; Neuroendocrine tumors; Urinary bladder neoplasms; Vanilmandelic acid

A 50-year-old man with diffuse abdominal pain had a pelvic CT scan that revealed a bladder tumor. Biopsy was performed by urology and the patient suffered a hypertensive crisis during the procedure. He hadn´t had a personal or family history of hypertension, flushing, palpitations or syncope. With a conclusive pathology of paraganglioma (immunohisto-chemistry reported intense and diffuse positive for chromogranin and synaptophysin, focal reactivity for the S100 protein and a proliferation index Ki67% of 1%), biochemical tests were carried out. Fractionated urinary metanephrines were normal: total metanephrines: 614 ug/24 hrs (RV <900 ug/24 hrs), normetanephrine: 423 ug/24 hrs (RV<600 ug/24 hrs), metanephrine: 141 ug/24 hrs (RV<300 ug/24 hrs); chromogranin A: 6.40 ng/ml (RV: 1.9-15 ng/ml) but vanilmandelic acid was elevated: 28.2 mg/24hrs (RV <13.6 mg/24 hrs). An 18 fluorodeoxiglucose PET/CT study (18 FDG PET/CT) showed an abnormal glucose uptake in the bladder with 16.9 SUVs. No distant metastases were reported. Surgical resection was performed successfully and antihypertensive medication was discontinued. The patient remains asymptomatic and normotensive (unmedicated). Results of genetic testing are pending [1-3]. Bladder paragangliomas (bPGL) are sympathetic tumors that represent 0.06% of all bladder tumors. Approximately 50-60% of these tumors present with adrenergic symptoms; catecholamine crisis during urination might occur in 30% and hematuria is the main manifestation in 60%. Up to 40% of bPGL are malignant.18 FDG PET/CT are a sensitive test to evaluate malignancy. It has shown a good usefulness in evaluating the extension of this sickness due to the fact that it may identify lesions undetected by tomography or magnetic resonance imaging. Its sensitivity is about 74% in patients with metastatic PGL, and it can reach 100% in SDHB (succinate dehydrogenase complex, subunit B) gene mutation carriers.

Acknowledgements

We thank José Luis Torres Grajales and Clínica Las Americas for helping us to get the image.

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