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More than 90% of cancer deaths are caused by cancer metastasis. Since cancer metastasis is the main cause of human deaths, antimetastatic treatment should be decisive factor for patients’ survival. Current cancer chemotherapy is mainly targeted on primary tumors and late stage patients’ survival has improved very little. It is suggested to improve the outcome of chemotherapy of cancer patients from different possible ways; e.g. to make more efforts to manufacture new types of antimetastatic drugs and optimize use of antimetastatic drugs in clinics. This review will describe how to optimized use of antimetastatic drugs in clinics.