Newborn Babies with Tetanus in Maternity Children Hospital Makah:- Center Experience from its Application to Prevent in the Kingdom of Saudi Arabia
Received Date: Jan 21, 2018 / Accepted Date: Jan 29, 2018 / Published Date: Feb 05, 2018
Neonatal tetanus (NNT), a disease preventable by immunization, is a major problem and a leading cause of neonatal mortality. To study the epidemiology, clinical appearances and outcomes of all patients diagnosed with neonatal tetanus. Moreover, to develop and supply a council to prevent NNT in the KSA. This cross sectional study was conducted at Maternity and Children’s Hospital, Makkah, KSA; a medical centre; from 2013 to 2017. All medical data for patients with suspected diagnosis of NNT were examined to get information about socio demographic properties. Fifty one patients were diagnosed with neonatal tetanus over 5 years in our hospital. All the cases are house delivery for unvaccinated mothers with cut the umbilical cord using unsterilized household scissors. Most of the patients presented with muscle spasms, refusal to eat and abnormal posture. All of the patients were intubated and receiving mechanical ventilation. Two of the patients died. It is essential to begin battle to achieve complete maternal tetanus toxoid immunization at primary health centers, during antenatal care. Immunization needs to be planed so pregnant women can be informed regarding the importance of authority clinics and the risks of unhygienic house birth, and immunization should be addressed with sufficient data. Pregnant women and those of childbearing age should be the first targets for these actions.
Keywords: Neonatal tetanus (NNT); Prevention; Infection disease; The Kingdom of Saudi Arabia (KSA)
Neonatal tetanus (NNT), immunization can control this disease, is a leading cause of neonatal mortality areas as a major health problem in many countries including KSA . Tetanus as a cause of neonatal deaths ranged from 16.4% to 72.5% in the rural areas and from 0% to 68.7% in the urban areas as reported by The World Health Organization (WHO) . One of the most underreported diseases . Global elimination of neonatal tetanus is of major public health problems due to the Underreporting of NT cases. Also, the underreporting of NT in developing countries have limited the impact of surveillance on disease control strategies, yet little consideration has been given to ways of improving the reporting system . Three steps are needed to complete the reporting. First; the public must have access to health services, and second, must use them. Third, the health services must report cases accurately and regularly to the suitable health organization [1,5]. Community-based NT mortality surveys demonstrate that current surveillance systems as used in developing countries observe only 2–8% of cases [1,3-6]. In 2004, WHO received reports of only 9318 cases of NNT, compared to an estimated 128 000 NNT deaths [7,8].
Tetanus is a highly fatal infection in the fetal stage and caused by a neurotoxin produced by C. tetani , a gram-positive, obligate and anaerobic rod-shaped bacterium that forms spores. C. tetani spores are everywhere in the environment, including soil, dust, manure, and in the gastrointestinal tracts of animals (including human beings), and can contaminate many surfaces and substances . The spores are extremely hardy but its destruction need prolonged exposure to iodine, hydrogen peroxide, formalin or gluteraldehyde or by autoclaving . The spores develop into bacteria when they enter the body. C. tetani spores usually enter the body through a wound or fracture in the skin. Neonatal tetanus usually occurs because of umbilical infections. We should know this, the spores germinate in the presence of anaerobic states. The endotoxin being the cause for tetanus; tetanus toxin; is one of the most potent toxins ever identified, with a minimum human lethal dose of <2.5 ng/kg [11-14]. Toxins are produced and spread via the blood stream and lymphatic system. Toxins act at several sites within the central nervous system, including peripheral motor end plates, spinal cord, and brain, as well as in the sympathetic nervous system. The characteristic clinical demonstrations of tetanus are caused when tetanus toxin interferes with release of neurotransmitters and blocking inhibitor impulses. This cause muscle contraction and spasm. Seizures may occur, and the autonomic nervous system may also be affected. The incubation period is usually 3-21 days (median 7 days) [15-18], although exceptional cases have been reported with incubation periods as short as one day or longer than a month [19,20]. The average incubation period for neonatal tetanus is shorter than that of non-neonatal tetanus. About 90% of neonates with tetanus develop symptoms in the first 3–14 days of life, mostly on days 6–8, distinguishing neonatal tetanus from other causes of neonatal mortality which typically occur in the first two days of life [6,21,22]. Dysphagia, neck, shoulder, back, or abdominal muscle stiffness and pain are other common early symptoms. Also, in neonatal tetanus, trismus and lip muscle rigidity interfere with normal sucking and feeding, which is the hallmark of disease onset . As disease severity increases, muscle rigidity extends throughout the body and muscle spasms begin, first in response to sensory stimuli but later progressing to spontaneous long-lasting excruciating spasms of many muscle groups .
In severe tetanus, sudden generalized tonic contractions of all muscle groups, or tetanospasms, result in opisthotonos, adduction of the shoulders, flexion of the elbows and wrists, and extension of the legs, usually accompanied by temperature rises of several degrees . Overall case fatality rates for patients admitted to hospital with neonatal tetanus in developing countries are 8-50%, while the fatality rate can be as high as 100% without hospital care . The true extent of the tetanus death toll is not known, since many newborns and mothers die at home and neither the birth nor the death is reported. MNT cases are clustered in poor, remote, and disenfranchised communities where unhygienic obstetric and postnatal practices prevail, and access to maternal tetanus toxoid immunization is poor. Differences in neonatal tetanus incidence and mortality of at least an order of magnitude have been identified between regions and countries, and between urban and rural areas within countries . In industrialized countries, neonatal tetanus ceased to be a substantial problem by the mid-20th century: once TT vaccination became widespread, neonatal tetanus disappeared [28-30]. By contrast, mortality rates as high as 67-110 per 1,000 live births were identified in rural populations in developing countries in the 1960s and 1970s with neonatal tetanus accounting for 50% or more of all neonatal deaths and 25% of infant mortality in some countries [31,32]. However, this situation has improved in the past 20 years . According to the Child Health Epidemiology Reference Group estimates from 2008, an estimated 59,000 newborns die of the disease each year; this translates into ~164 deaths in children under one month of age every day or one death every 9 min. Several thousand mothers are also estimated to die of maternal tetanus . Many countries still striving to achieve elimination have improved vaccine coverage in most districts and are close to meeting elimination criteria.
There are no published data on NNT from the KSA, except for one report in adult patients. However, a range of 4-14 patients; over the last five years; 2009-2013, was reported to the WHO [34,35]. This report from King Faisal Specialist Hospital at our capital city; Riyadh; reviews the clinical aspects and outcomes of NNT cases treated over the last 22 years. The objective of this study is to high-lighting the occurrence of this preventable disease with the desire of gathering more epidemiologic facts and developing a national strategy for eliminating NNT.
Patients and Methods
The study protocol was approved by our institutional review board. This cross sectional study was conducted at Maternity and Children’s Hospital, Makkah, KSA; a medical centre; from 2013 to 2017. We examined and surveyed 51 newborns. All medical data for patients with suspected diagnosis of NNT were examined to get information about sociodemographic properties containing gestational age, birth weight, nationality, gender, area of stay, antenatal care of the mother and immunization against tetanus. In addition, place of delivery, attendance of the birth by medical or paramedical personnel and the instruments employed to cut the umbilical cord. The clinical characteristics of the patients were obtained after admission, including the signs; symptoms on introduction and the management to get healthy and improved life. The managements supplied were mechanical ventilation and the medications used for paralysis and controlling convulsions. The end results for death or discharge and the neurological examination results were also noted.
Frequency distribution, chi-square and t-test analysis will be used to compare percentages of studied parameters among patients group participated in the study. The statistical analyses were performed using IBM SPSS Statistics v. 18 for Windows. P-value <0.05 was used as the level of significance.
Results and Treatment
All the cases are house delivery for unvaccinated mothers with cut the umbilical cord with unsterilized scissors and most of them came to our emergency department (ER) at the age of 6-7 days with poor feeding and spastic, weight range between 3-3.5 kg. All of them had managed initially in the ER by ventilation and anti-tetanus (Toxoid) vaccine was given. Also, started antibiotic immediately and then shift the babies to a neonatal intensive care unit (NICU). In NICU; the babies admitted in dark room, then started valium and pavilion infusion, under cardiac monitoring and respiratory care support. All cultures were sent on the 3rd day the babies started feeding through orogastric tube and stilled on valium; and pavlon infusion and ventilated support. The sociodemographic properties of these patients and their mothers are shown in Table 1.
|No antenatal care||90|
|No Tetanus toxoid or Tetanus antitoxin||100|
|TT, one dose||0|
|Healthcare hospital center||0|
to cut the umbilical cord
Table 1: Sociodemographic properties for mothers of newborn babies with neonatal tetanus for this study; *Childbirth is attended by trained healthcare employee.
CT scans for the brain were done for all babies. No evidence of birth asphyxia. Physiotherapy came every day for babies. Forty nine babies were discharged followed in an Out Patient Department of the hospital, The Tetanus Toxoid vaccine (TT) immunization services were provided to our suspected patients with NNT. Since the protection received from the mother will last only for a few months, infants are given TT as a combined vaccine with diphtheria toxoid and pertussis vaccine (DPT). The immunization program is a part of primary health care and the services are provided through the existing health delivery systems. The vaccination services are available at the hospitals, maternal and child health clinics, and dispensaries in the urban areas and in the primary health centers and the sub centers in the rural areas. CT scans for the brain for all babies, were normal. Most of our cases cured and discharge, three out of 52 babies died due to sepsis. Forty nine babies were discharged and followed in an Out Patient Department of the hospital. A patent airway should be maintained and, depending on the severity of disease, endotracheal intubation or tracheostomy and mechanically assisted respiration may be lifesaving. Sedation and muscle relaxant drugs were used to control muscle spasms. Agents to control autonomic nervous system instability may be required. Active immunization may be initiated concurrently with treatment.
This study postulated the fact that all our patients suspected with NNT, were delivered at house of residence a way from health care organization. This demonstrates that these pregnant women like the birth process to occur at house or obligate for this due to our customs. However, they not having knowledge of the complications that accidently may occur as NNT. The majority of these women did not get antenatal care after or before the baby birth. No information about whether a health care worker was present was recorded in the patient’s medical chart as well.
Educating pregnant women and women of child-bearing age in high-risk areas during antenatal care is very important to raising their awareness of birth at health care centers or at least having a trained assistant if house delivery is obligatory. It appears that counseling on important vaccines for pregnant women is not adequately provided by health care personnel. The primary health care centers may not provide sufficient information to pregnant women, particularly regarding the importance of immunization, including the tetanus vaccine. The mean age of patients at the onset of disease was 6.5 days. The most common clinical features were muscle spasms, refusal to eat, abnormal posture and fever. The clinical presentation of our patients was not different from that indicated in other previous reports [10,11]. It is the current protocol of the NICU at our hospital to intubate and ventilate most patients with a diagnosis of NNT based on reports of improved outcomes with this intervention [12,13]. The most frequent clinical complications were pneumonia, followed by difficulty feeding and septicemia. Hypothermia, decreased need for sedation and diminished signs of tetanus usually indicate the onset of bronchopneumonia. Some data were missing from the patients’ medical records; for example, information regarding maternal immunization, attendance of the delivery and causes of death was not recorded. Thus, we will need to consider this NNT is a medical emergency requiring hospitalization, immediate treatment with human tetanus immune globulin, to control muscle spasm, aggressive wound care and a tetanus toxoid booster. If tetanus immune globulin is unavailable, Immune Globulin Intravenous can be used.
Thus, we can say that newborns with tetanus were endemic in the KSA and were the cause of many deaths in the past. Our university hospitals are the only referral centers for the intensive care management of tetanus patients in the area. Adequate routine vaccination for prevention of this disease is important as none of our patients had been immunized ever against tetanus. The need for routine immunization, especially for pregnant women, was obvious. The expanded program on immunization for the entire country was initiated in 1990s. At that time, we expect that only very small percentage of women of childbearing age had received adequate vaccination against tetanus. Successful elimination of neonatal tetanus requires protection of more than 80% of the infants at birth, through complete vaccination of their mothers and by clean deliveries and cord-care application . The increase in the number of rural and urban health centers, training of a larger number of midwives and general practitioners, improve the educational programs through the mass media and motivation of people for active contribution in the vaccination programs by health authorities’ and local religious leaders resulted in greatly better results.
These actions can save many lives each year and, therefore, should be continued. Our examinations indicate a developing gradually and fortunate decline in the number of suspected cases in this area . However, it should not be forgotten that undetected or unreported cases are still occur. Therefore, we are still far from the ideal situation of elimination, which will need nationwide attempt for good program of large-scale immunization.
- Expanded Programme on Immunization (1982) The use of survey data to supplement disease surveillance. Wkly Epidemiol Rec 57: 361-362.
- World Health Organization (1999) Progress towards the global elimination of neonatal tetanus, 1990–1998. Wkly Epidemiol Rec 74: 73-80.
- Expanded Programme on Immunization (1994) Global Advisory Group. Part II: achieving the major disease control goals. Wkly Epidemiol Rec 69: 31-35.
- Stanfield JP, Galazka A (1984) Neonatal tetanus in the world today. Bull World Health Organ 62: 647-669.
- Whitman C, Belgharbi M, Gasse F, Torel C, Mattei V, et al. (1992) Progress towards the global elimination of neonatal tetanus. World Health Stat Q 45: 248-256.
- Singh J, Datta KK, Foster SO (1997) Sensitivity of neonatal tetanus surveillance system in India. Indian Pediatr 34: 398-401.
- World Health Organization (2009) WHO vaccine-preventable diseases monitoring system 2009 global summary. WHO/IVB/2009. Geneva: WHO; 2009.
- Expanded Programme on Immunization (2009) Validation of neonatal tetanus elimination in the Congo by a lot quality-assurance cluster sample survey. Wkly Epidemiol Rec 84: 470-476.
- Collier L, Balows A, Sussman M (1998) Topley & Wilson’s Microbiology and Microbial Infections. New York: Oxford University Press 38: 694-722.
- Wassilak SGF, Roper MH, Murphy TV, Orenstein WA (2004) Tetanus Toxoid. In: Plotkin SA, Orenstein WA, eds. Vaccines. Philadelphia, USA: W.B. Saunders. pp: 745-781.
- Yen LM, Dao LM, Day NP, Waller DJ, Bethell DB, et al. (1994) Role of quinine in the high mortality of intramuscular injection tetanus. Lancet 344: 786-787.
- Gill DM (1982) Bacterial toxins: a table of lethal amounts. Microbiol Rev 46: 86-94.
- Patel JC, Mehta BC (1999) Tetanus: study of 8,697 cases. Indian J Med Sci 53: 393-401.
- Brauner JS, Vieira SR, Bleck TP (2002) Changes in severe accidental tetanus mortality in the ICU during two decades in Brazil. Intensive Care Med 28: 930-935.
- Thwaites CL, Yen LM, Nga NT, Parry J, Binh NT, et al. (2004) Impact of improved vaccination programme and intensive care facilities on incidence and outcome of tetanus in southern Vietnam, 1993-2002. Trans R Soc Trop Med Hyg 98: 671-677.
- Farrar JJ, Yen LM, Cook T, Fairweather N, Binh N, et al. (2000) Tetanus. J Neurol Neurosurg Psychiatry 69: 292-301.
- Bruce D (1917) Tetanus: Analysis of one thousand cases, Presidential Address. Trans R Soc Trop Med Hyg 11: 1-53.
- Anonymous (1982) Expanded programme on immunization. Prevention of neonatal tetanus. Wkly Epidemiol Rec 57: 137-144.
- Salimpour R (1978) Tetanus of the newborn in Tehran. A ten year study of 880 cases [proceedings]. J Trop Pediatr Environ Child Health 24: 140-142.
- Bleck TP, Brauner JS (2004) Tetanus. In: Scheld WM,Whitley RJ, Marra CM, eds. Infections of the Central Nervous System. Philadelphia Lippincott,USA: Williams & Wilkins pp 625-48.
- Dunn ER (2002) The altered whistle in tetanus. Med J Aust 16: 177-687.
- Galazka A, Stroh G (1986) Guidelines on the community based survey on neonatal tetanus mortality. Geneva: World Health Organization.
- Weinstein L (1973) Tetanus. N Engl J Med 289: 1293-1296.
- Roper MH, Vandelaer JH, Gasse FL (2007) Maternal and neonatal tetanus. Lancet 370: 1947-1959.
- Bytchenko B (1966) Geographical distribution of tetanus in the world, 1951-60. A review of the problem. Bull World Health Organ 34: 71-104.
- Rushdy AA, White JM, Ramsay ME, Crowcroft NS (2003) Tetanus in England and Wales, 1984-2000. Epidemiol Infect 130: 71-77.
- Wassilak SGF, Roper MH, Murphy TV, Orenstein WA (2004) Tetanus Toxoid. In: Plotkin SA, Orenstein WA eds. Vaccines. Philadelphia, USA: W.B. Saunders. pp: 745–781.
- Schofield FD, Tucker VM, Westbrook GR (1961) Neonatal tetanus in New Guinea. Effect of active immunization in pregnancy. Br Med J 2: 785-789.
- Berggren WL (1974) Administration and evaluation of rural health services. I. A tetanus control program in Haiti. Am J Trop Med Hyg 23: 936-949.
- Neonatal Tetanus Elimination WHO (1989) WHO, Expanded Program on Immuniation, Global Advisory Group. WHO/EPI/GAG/89/WP.9. Tokyo: WHO.
- UNICEF (2011) Elimination of Maternal and Neonatal Tetanus.
- Meegan ME, Conroy RM, Lengeny SO, Renhault K, Nyangole J (2001) Effect on neonatal tetanus mortality after a culturally-based health promotion programme. Lancet 358: 640-641.
- Ray B, Balmer P, Roper MH (2006) Immunological basis for immunization - Module 3: Tetanus (Revision).
- World Health Organization (2003) WHO recommended standards for surveillance of selected vaccine-preventable diseases.
- Lubbad EH, Khazidar AM, Ayyub M (2004) Tetanus experience in a public hospital in western Saudi Arabia. Saudi Med J 24: 1325-1328.
- World Health Assembly (1989) Expanded Program on Immunization.
- World Health Organization (1995) Expanded Program on Immunization.
Citation: Ahojaili N, Al-zahrani AS, Al-malki H, Kotbi I, salam L, et al. (2018) Newborn Babies with Tetanus in Maternity Children Hospital Makah:- Center Experience from its Application to Prevent in the Kingdom of Saudi Arabia. Immunome Res 14: 149. Doi: 10.4172/1745-7580.1000149
Copyright: ©2018 Ahojaili N, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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