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Nigella sativa Linn. and Lower Urinary Tract Infection Treatment

Journal of Surgical Pathology and Diagnosis
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  • Case Report   
  • J Surg Pathol Diagn 2018, Vol 1(1): 101

Nigella sativa Linn. and Lower Urinary Tract Infection Treatment

Amalia Tri Utami*
Maulana Malik Ibrahim State Islamic University Malang, Indonesia
*Corresponding Author: Amalia Tri Utami, Maulana Malik Ibrahim State Islamic University Malang, Indonesia, Email: [email protected]

Received Date: Sep 06, 2017 / Accepted Date: Sep 18, 2017 / Published Date: Jan 25, 2018

Keywords: UTIs; Microorganism; Escherichia coli; Antimicrobial

Methods

The capsules contain 500 mg of Nigella sativa Linn. Versus placebo capsules were given to woman aged 18 to 25 years old. A total of 30 women with symptomatic UTIs were randomized to Nigella sativa Linn. or placebo in 3 treatment arms of A- Nigella sativa Linn. 3 times daily (10), B-Nigella sativa Linn. Breakfast then placebo at lunch and dinner (10), and C-placebo 3 times daily (10). Every week in a month, the woman were asked about the symptoms (Figure 1 and Table 1).

surgical-pathology-diagnosis-significance-level

Figure 1: The data was analyzed. Using the P-value approach: The pvalue is p=0.0961 and since p=0.0961 ≥ 0.01, It is concluded that the null hypothesis Ho is not rejected. Therefore, there is not enough evidence to claim that some of the population medians are unequal, at α=0.01 significance level.

  Bacterial Concentration
Woman Group A Group B Group C
  Before On going After Before On Going After Before On Going After
1 2.4 X 105 1.5 X 103 2 X 10 2.4 X 105 1.5 X 105 6 X 103 2.7 X 105 1.7 X 105 1.6 X 105
2 1.7 X 105 8 X 102 1 X 10 2.8 X 105 1.1 X 105 7 X 103 2.2 X 105 1.8 X 105 1.5 X 105
3 3.2 X 105 1.5 X 104 2 X 10 1.7 X 105 1.2 X 105 5 X 103 2.3 X 105 1.9 X 105 1.5 X 105
4 2.1 X 105 1 X 103 3 X 10 1.9 X 105 1.4 X 105 6 x 103 2.5 X 105 1.2 x 105 1.1 X 104
5 1.6 X 105 2 X 102 4 X 10 1.8 X 105 1.5 X 104 4 X 103 1.7 X 105 9 X 104 3 X 104
6 2.7 X 105 7 X 102 7 X 10 1.7 X 105 3 X 103 6 X 102 1.6 X 105 7 X 103 8 X 103
7 2.2 X 105 3 X 102 5 X 10 2.2 X 105 6 X 103 7 X 102 1.4  X 105 9 X 103 9 X 102
8 1.9 X 105 1 X 104 2 X 10 2.3 X 105 9 X 103 3 X 102 1.2 x 105 8 X 103 7 X 103
9 2.8 X 105 1.7 X 103 8 X 10 2.1 X 105 7 X 103 8 X 102 1.3 X 105 5 X 103 5 X 103
10 2.3 X 105 7 X 102 4 X 10 2.9 X 105 1.7 X 104 1 X 102 1.4 X 105 6 X 103 1.5 X 103
Mean 2.29 X 105 3.09 X 103 3.5 X 10 2.18 X 105 5.77 X 104 3.05 X 103 1.97 X 105 7.85 X 104 5.23 X 104

Table 1: Bacterial Concentration on Culture Urine * CFU/ml.

Results & Discussion

In later studies, seed extracts of Nigella sativa Linn. were found to inhibit the growth of Escherichia coli , Bacillus subtilis and Streptococcus feacalis [1,2]. Nigella sativa Linn. seeds caused concentration-dependent inhibition of Gram-positive Staphylococcus aureus and Gram-negative Pseudomonas aeruginosa and E. coli and a pathogenic yeast Candida albicans. The extract showed antibacterial synergism with streptomycin and gentamicin and showed additive antibacterial action with spectinomycin, erythromycin, tobramycin, doxycycline, chloramphenicol, nalidixic acid, ampicillin, lincomycin and sulfamethoxyzole–trimethoprim combination. Interestingly, the extract successfully eradicated a non-fatal subcutaneous staphylococcal infection in mice when injected at the site of infection [3]. Recently, crude extracts of N. sativa showed promising antimicrobial effects against bacterial isolates with multiple resistances against antibiotics [4]. The most effective extracts were the crude alkaloid and water extracts. The seeds are characterized by a very low degree of toxicity (Ali and Blunden, 2008).

Conclusion

These data suggest there are protective effects of Nigella sativa Linn. against symptomatic urinary tract infections.

References

Citation: Utami AT (2018) Nigella sativa Linn. and Lower Urinary Tract Infection Treatment. J Surg Pathol Diagn 1:101.

Copyright: © 2018 Utami AT. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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