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Non-invasive Ventilation in Adults: A Brief Update | OMICS International
ISSN: 2161-105X
Journal of Pulmonary & Respiratory Medicine

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Non-invasive Ventilation in Adults: A Brief Update

Leonardo S Roever-Borges* and Elmiro santos Resende

Department of Clinical Research, Federal University of Uberlândia, Av. Pará, 1720-Bairro Umuarama, Uberlândia - MG - CEP 38400-902, Brazil

*Corresponding Author:
Leonardo S. Roever-Borges
Department of Clinical Research
Federal University of Uberlândia
Av. Pará, 1720-Bairro Umuarama
Uberlândia - MG - CEP 38400-902, Brazil
Tel: +553488039878
[email protected]

Received date: June 08, 2015; Accepted date: December 10, 2015; Published date: December 16, 2015

Citation: Roever-Borges LS, Resende ES (2015) Non-invasive Ventilation in Adults: A Brief Update. J Pulm Respir Med 5:299. doi:10.4172/2161-105X.1000299

Copyright: © 2015 Roever-Borges LS, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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The use of noninvasive ventilation and noninvasive continuous positive airway pressure by mask has increased substantially. The main indications are exacerbation of chronic obstructive pulmonary disease (COPD), cardiogenic pulmonary oedema, trauma, pulmonary infiltrates in immunocompromised patients, and weaning of previously intubated stable patients with COPD. In this mini-review article, we summarize the results of various studies in which noninvasive ventilation was applied and discuss the role and efficacy of noninvasive ventilation.


Acute respiratory distress syndrome; Noninvasive ventilation; Respiratory failure


Noninvasive ventilation (NIV) refers to positive pressure ventilation delivered through a noninvasive interface (nasal mask, facemask, or nasal plugs), and it is used in patients with chronic hypercapnic respiratory failure caused by chest wall deformity, neuromuscular disease, COPD, posttraumatic hypoxemic respiratory failure, obesity hyperventilation syndrome, hypercapnic encephalopathy syndrome, non-hypercapnic respiratory failures or impaired central respiratory drive [1-5].

NIV has now become an integral tool in the management of both acute and chronic respiratory failure, in both the home setting, emergency room and in the intensive care unit [6-8].

The advantages of NIV over mechanical ventilation (MV) include the elimination of possible complications associated with endotracheal intubation, reduced incidence of infections related to MV, maintenance of speech and swallowing, greater comfort and flexibility of use to the patient as well as the preservation the defense mechanisms of the airway [9-11].

The consensus of the American Association of Respiratory Care endorses the use of NIV if 2 or more of the criteria are present (Table 1) [12-17].

Signs and symptoms of acute respiratory distress Gas exchange abnormalities
. Moderate to severe dyspnea
. RF ≥ 24
. Signs of increased work of breathing, paradoxical breathing or the use of accessory muscles
. pH < 7,35 with PaCO2 > 45 mmHg
. Hypoxemia with Pa O2/FIO2 < 200
Contraindications to NIV
.Severe upper gastrointestinal bleeding and postoperative esophageal surgeries.
.Severe Encephalopathy (GCS < 10)
.Respiratory or cardiac arrest
.High risk for aspiration and inability to clear secretions
.Trauma, deformity, facial or neurological surgery
.Patient decline
.Unable to fit mask
.Unstable cardiac arrhythmia and hemodynamic instability
.Organ failure
.Upper airway obstruction
.Inability to protect airway or cooperate
.Severe psychomotor agitation and uncooperative patient.
.Hypotensive shock
.Total upper airway obstruction
. Need for emergency intubation
Complications of NIV
Related to the mask Related airflow or pressure generated
.Edema or erythema
.Ulceration of the nose bridge
. Leaks
.Nasal congestion
.Local pain
.Nasal dryness and /or oral
.Gastric distension
Risk factors for failure of NIV
Age >65 years
Glasgow <11
Tachypnea (> 35 bpm)
pH <7,25
APACHE II score >12 at the time of extubation.
Asynchrony with the ventilator
Absence of teeth
Multiple organ failure
Cardiac failure as the cause of intubation.
Chronic cardiac failure.
Arterial partial carbon dioxide pressure >45 mmHg after extubation.
Patients with neuromuscular diseases
Obese patients
Excessive leakage;
Hypersecretive patients;
Intolerance by the patient;
Lack of improvement in the first two hours: maintenance of tachypnea and respiratory distress, no improvement in PaCO2 and pH.
Chronic respiratory disease with ventilation >48 hours and hypercapnia during spontaneous breathing trial.
Acute exacerbation of chronic obstructive pulmonary disease.
Multiple comorbidities.
Weak cough or stridor after extubation Hypercapnia.

More than one failure in the spontaneous respiration test

Table 1: GCS: Glasgow Comma Scale, RF: respiratory frequency.

The main types of ventilation modes for noninvasive support are shown in Table 2 [15-17].

Modes Description
BIPAP . Flow cycled
.Two pressure levels (IPAP and EPAP)
CPAP . Spontaneous ventilation
. Constant airway pressure

Table 2: Types of ventilation modes for NIV. BIPAP - bilevel positive airway pressure, IPAP - inspiratory positive airway pressure; EPAP - expiratory positive airway pressure.CPAP - continuous positive airway pressure.

NIV is an important option in the management of patients who are at risk of or who have respiratory failure in the acute and chronic sharpened care setting (Table 3).

Level of evidence Clinical condition
Level 1 - Recommendation based on randomized clinical trials and systematic reviews Exacerbation of COPD
Acute cardiogenic pulmonary edema
Weaning and extubation in COPD patients
Hypoxic respiratory failure in immunocompromised patients
Hypoventilation syndrome of obesity
Posttraumatic hypoxemic respiratory failure
Weaning strategy in adults with respiratory failure
Reintubation rate in patients undergoing cardiothoracic surgery
Prehospitalnoninvasiveventilationfor acute respiratory failure
Acute respiratory failuredue to chesttrauma.
Level 2 - Recommendation based on systematic review of cohort studies Patients who refuse intubation, terminally ill and on palliative care
Extubation failure prevention in patients with COPD or acute cardiogenic pulmonary edema
Community-acquired pneumonia in patients with COPD;
Respiratory failure in postoperative (prevention and treatment)
Level 3 - Systematic review of case-control studies Neuromuscular disease and kyphoscoliosis
Partial obstruction of the upper airways
Chest trauma
Prevent or to treat perioperativeacute respiratory failure
Level 4 - Number of cases (cohort study and case-control) Cystic fibrosis
Hypercapnic encephalopathy syndrome
Amyotrophic lateral sclerosis.
Non-COPD and non-trauma patients with acute hypoxemic respiratory failure
Exercise tolerance in heart failure
Acute respiratory failure in delirious patients

Table 3: Level of evidence and clinical condition. COPD: chronic obstructive pulmonary disease.


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