Department of endocrinology and metabolic diseases, Ghent University, Belgium
Received Date: June 25, 2014; Accepted Date: August 01, 2014; Published Date: August 05, 2014
Citation: Comhaire F (2014) Nutriceutical Approach to the Metabolic Syndrome. Endocrinol Metab Synd 3:134. doi: 10.4172/2161-1017.1000134
Copyright: © 2014 Comhaire F, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Metabolic syndrome; Complementary medicine; CAM; Nutriceutical; Momordica charantia; Prediabetes
The metabolic syndrome is probably one of the most important health threatening pathologies in modern society and constitutes a major cardiovascular risk factor. Treatment options include changes of life style and nutrition, as well as medication and bariatric surgery. These mainly aim at reducing insulin resistance, and medication needs to be taken over a very long period of time, with potential toxic side effects.
Nutriceutical food supplements (NFS) which contain herbal extracts, minerals and vitamins in quantities not exceeding the recommended daily intake (RDI) , are free of adverse effects , and their role and importance have recently been acknowledged by the World Health Organization . The combination of substances with complementary effects is expected to act in synergisms. The NFS generally aims at complementing dietary deficiencies, particularly in elderly persons  and patients taking medication . In the metabolic syndrome, a specific NFS focusses on reducing the impact of inflammation and of oxidative overload, and on correcting the impaired metabolism.
The present paper describes the rationale for the composition of a specific NFS, and its biological effects in patients with metabolic syndrome/pre-diabetes.
The composition of the nutraceutical food supplement
The NFS consists of the following products:
Capsules with 350 mg of Momordica charantia (bitter melon or bitter gourd) dry extract 1:4, of which 3 per day.
Pills (called “Improve®”, Nutriphyt Ltd. Oostkamp, Belgium) containing: Lepidium meyenii extract (MACA): 250 mg, Pine Bark extract (Pycnogenol®, Horphag, Switzerland) 100 mg, L-acetylcarnitine: 100 mg, Co-enzyme ubiquinone Q10: 25mg, Astaxanthin (Fuji Health Science, Inc. & AstaReal, Inc., Burlington, NJ, USA): 4 mg, Zincpicolinate: 7.5 mg, Vit B6 (pyridoxine): 3 mg, Vit B9 (folic acid) 0.2 mg, and Vit B12 (cyanocobalamine): 15 µg.
Patients should take 2 pills per day together with twice per day 1 g of fish oil, rich in eicosapentaenoic adid (EPA) and docosahexaenoic acid (DHA).
Biological effects of the NFS
The extract of the bitter melon has extensively been tested in the treatment of diabetes in rats . It increases sensitivity of the insulin receptor , and favourably influences the metabolic syndrome  and diabetes  in humans.
In the metabolic syndrome, the inhibitory effect of Momordica extract on the 11β-hydroxysteroid dehydrogenase type 1 is particularly relevant . This enzyme favours the hydroxylation of cortisone, that has a primarily mineralocorticoid effect, to cortisol (hydrocortisone) that increases blood sugar by gluconeogenesis (Figure 1). There is evidence for increased activity of this enzyme in adipose cells , and that this may be an important aetiological factor in the pathogenesis of obesity-associated diabetes. Inhibitors of 11β-hydroxysteroid dehydrogenase increase energy expenditure and reduce atherosclerosis.
The bitter melon extract increases phosphorylation of acetyl-CoA carboxylase and c-AMP-activated protein kinase (PKA)  reducing lipogenesis and increasing thermogenesis and lipolysis . The extract down-regulates the expression of peroxisome proliferator-activated receptor (PPAR)-gamma, nuclear factor kappaB (NF-kB), and interferon-gamma in heart tissue of obese rats, with cardio-protective effect and reduction of inflammation .
In addition, the extract has been shown to exert chemo-protective effect against prostate cancer cells , human embryonic kidney cells and colon cancer cells in vitro , and to inhibit Epstein-Barr virus-induced tumour promotion .
Astaxanthin is contained in the dried biomass of the microscopic algae Haematococcus pluvialis. It is a polar carotenoid with potent antioxidant activity. In contrast to Vitamin A (retinol), that inserts longitudinally between the phospholipid layers of the cell membrane, Astaxanthin builds in perpendicularly through the membrane. This explains why Astaxanthin is non-toxic, in contrast to Vit A that has been shown to be toxic and may be teratogenic in higher dose [18-20]. Astaxanthin exerts an antioxidant effect that is many times stronger than that of Vitamin E , and it has a documented anti-inflammatory activity . It reduces phospholipid hydroxides, and decreases stress- induced modifications that impair lipid utilization in the mitochondria .
Oxido-reductase ubiquinone Q10
Reactive oxygen species (ROS) are generated during the process of energy production during the Krebs cycle in the mitochondria. These ROS must be scavenged since they inhibit the enzymatic reactions of the Krebs cycle, reducing the production of ATP. The anti-oxidant Ubiquinone Q10 improves mitochondrial function  and energy production , and diminishes lipid peroxidation .
Zinc (zincbisglycinate) is part of many enzymes playing a pivotal role in cell functions. In association with vitamin B6  zinc promotes the conversion of short-chain omega-3 poly-unsaturated fatty acids (such as alfa-linolenic acid) into their long-chain derivatives by acting as co-factors of the elongase and desaturase enzymes . The long-chain polyunsaturated omega-3 fatty acids docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) serve as substrates for the energy producing metabolism of the mitochondria.
L-Acetylcarnitine is an amino acid that plays a pivotal role in the transportation of the long-chain omega-3 polyunsaturated fatty acids (DHA or Cervonic acid, and EPA) from the cell cytoplasm into the mitochondria, where these are metabolised in the Krebs cycle. L-acetylcarnitine increases the production of energy as ATP .
Vitamins B6, B9 and B12
The association of vitamins B6 (pyridoxine), B9 (folic acid), and B12 (cyanocobalamine) enhances the metabolism of homocysteine , decreasing its concentration and availability in body fluids. Homocysteine concentration is increased in patients with the metabolic syndrome , and it is an independent risk factor for vascular disease.
Lepidium meyenii (MACA) belongs to the cruciferous (Brassica) family, and grows in the Peruvian Andes mountains. It is considered a phyto-adaptogen which increases the production of the Heat Shock Protein P 72, thus reduces the negative impact of stress [32,33] on protein conformation and cell death .
Pine bark extract
The extract of the bark of the (Mediterranean) pine tree (Pycnogenol®, Horphag, Switzerland) is rich in anthocyanidins with anti-oxidant effect, and it reduces inflammatory reaction through the inhibition of the Cyclo-oxygenase (COX) enzymes 1 and 2 [35,36] and of the Nuclear Factor kappa B (NF-kB) . In addition it has a strong anti-oxidant effect and restores the function of the capillary epithelium .
Long-chain poly-unsaturated omega-3 fatty acids
It is recommended to complement the nutriceutical with the long-chain poly-unsaturated fatty acids of the ω-3 group (DHA and EPA) present in fish oil and krill oil. These fatty acids improve the fluidity and functions of the cell membrane, and they also serve as substrate for the energy metabolism of the mitochondria.
A number of trials have confirmed the effectiveness of the combination of nutriceuticals in correcting, or at least mitigating, the signs and symptoms of the metabolic syndrome. As an example, the laboratory results are listed (Table 1) after 4 weeks of nutriceutical treatment in this first patient treated with the novel approach, being a 72 years old overweight lady.
Table 1: The patient (HJ) was diagnosed with incipient type II diabetes, with postprandial hyperglycaemia, slightly elevated fast haemoglobin A1c, highly elevated Insulin and C-peptide, moderately elevated total cholesterol, triglycerides and C-Reactive Protein (CRP). After 4 weeks of nutriceutical supplementation all biological variables have improved, some returning to normal values.
The metabolic syndrome encompasses a multitude of processes and deregulations of several important cellular functions. Treatment must aim at changing the diet and life style of patients, but this requires the full collaboration and motivation of the person involved. This is often difficult to obtain, and commonly patients relapse into their old habits. Medication can be efficient, as is bariatric surgery, but may carry undesired side effects. The judicious combination of herbal extracts, vitamins, minerals and natural agents in the specific nutriceutical food supplements described above is non-toxic, and does not interfere with the pharmacokinetics of allopathic medication. It may help to restore particular steps of cell metabolism, improving the health of patients. The present paper illustrates the first step (proof of principle) in the process of validation of the nutriceutical supplement by estimating its effects on surrogate markers in an open label setting including a limited number of patients. This should precede possible large scale controlled trials .