alexa Nutrition and its Important Role in Maintaining an Adequate Immunity during Chemotherapy | OMICS International
ISSN: 2161-0932
Gynecology & Obstetrics

Like us on:

Make the best use of Scientific Research and information from our 700+ peer reviewed, Open Access Journals that operates with the help of 50,000+ Editorial Board Members and esteemed reviewers and 1000+ Scientific associations in Medical, Clinical, Pharmaceutical, Engineering, Technology and Management Fields.
Meet Inspiring Speakers and Experts at our 3000+ Global Conferenceseries Events with over 600+ Conferences, 1200+ Symposiums and 1200+ Workshops on
Medical, Pharma, Engineering, Science, Technology and Business

Nutrition and its Important Role in Maintaining an Adequate Immunity during Chemotherapy

Hoefel AL* and Poltronieri TS

Serra Gaucha University, Caxias do Sul, Brazil

*Corresponding Author:
Ana Lucia Hoefel
Faculty of Nutrition, Serra Gaucha University
Avenida Os 18 do Forte 2366, Caxias do Sul, 95020-472, Brazil
Tel: 00 55 54 21016000
E-mail: [email protected]

Received date: May 26, 2016; Accepted date: August 03, 2016; Published date: August 10, 2016

Citation: Hoefel AL and Poltronieri TS (2017) Nutrition and its Important Role in Maintaining an Adequate Immunity during Chemotherapy. Gynecol Obstet (Sunnyvale) 7:07. doi:10.4172/2161-0932.S5:07

Copyright: © 2017 Hoefel AL, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Visit for more related articles at Gynecology & Obstetrics


There is a high rate of cancer, particularly gynecological and breast cancers among American women. Chemotherapy is commonly used as a means of treating this disease, but it can cause a range of undesirable side effects. Studies have therefore been undertaken in an attempt to identify complementary forms of treatment which may reduce these side effects, and a number of compounds have produced promising results. Examples of these are the fatty acids omega-3, β-glucan, and glutamine, all of which have been shown to increase immunity to gynaecological cancer, and have brought about improvements in the general clinical state of patients undergoing oncological therapy. However, studies also need to be carried out to increase our understanding of the beneficial properties of particular types of nutritional substances, and of developing diagnostic methods which can detect alterations in the transport of amino-acids to cancerous cells, especially in relation to the metabolic function of glutamine, thus making it easier for medical practitioners to take decisions concerning relevant supplementary nutrition.


Cancer; Chemotherapy; Metabolic function; Omega-3; β- glucan; Glutamine

Role of Nutrition in Cancer Chemotherapy

Each year, almost 90,000 American women are diagnosed with gynaecological tumours and submitted to oncological treatment, such as Chemotherapy (CT) [1]. This is a very aggressive way of combatting cancer, and can produce a wide range of side effects [2]. Studies have therefore been undertaken in an attempt to identify nutritional substances which can help reduce these side effects and complement the treatment of cancer [3,4]. In this brief review, we will refer to three classes of functional and nutraceutical substances which display high potential as supplementary forms of treatment of patients undergoing CT [5].

Eicosapentaenoical Acid (EPA) and Docous-Hexanoical Acid (DHA) are derivatives of the polyunsaturated acid omega-3, and have been shown to produce marked therapeutic improvements in a number of patients undergoing CT. These improvements include an increase in the effectiveness, and a reduction in the toxicity, of drugs prescribed [6,7], thereby producing a better response to CT. At the same time, there has been a considerable decrease in the side effects caused by such treatment, particularly in terms of improvement in appetite and body weight, survival rates and general quality of life, as well as a reduction in the time spent in hospital, and in the gravity of post-surgical infections [6,8,9].

It is extremely important to strengthen the immunological system during oncological treatment [10], since both the CT and the cancer itself can have a direct effect on it [1]. β-glucan is a polissacarid complex found in foodstuffs such as mushrooms [11] and oats [12], and is able to modulate immunity, thus maximising interactive potential, both by stimulating the survival of probiotic cultures, and through antitumoral activity [13-17]. In addition, probiotics constitute a group of functional substances closely related to the reduction of the side effects of CT, such as diarrhoea, while contributing to improvements in the immune system by helping to modulate the micro-biotics of the intestines [18-21].

Although glutamine is not an essential amino-acid, it contributes significantly to the survival of cells, and one of its functions is to participate in the synthesis of proteins and the biosynthesis of nucleotids, while at the same time signalling and activating mTOR. It is also vital to the proliferation and differentiation of cells [22-25]. It is often given as a nutritional supplement to oncological patients undergoing CT, especially in cases where mucositis or diarrhoea occur. In relation to mucositis, glutamine stimulates cicatrisation by strengthening the immune system, thereby aiding the recuperation of oral mucus. In the case of diarrhoea, glutamine is able to regenerate the villi by producing improvements in intestinal function [19-25].

As cancerous cells grow rapidly, they have a greater need for aminoacids [26]. Tumours can modify the regulation of the transporters in some amino-acids because of high demand, whilst at the same time improving levels of chemo-resistance [22-25,27,28]. This is particularly evident in the metabolic path of glutamine, and is related to increased proliferation of tumours and a consequent deterioration in the clinical condition of patients [26]. Some cancerous cells can selectively alter the intake of glutamine, thus reducing the effectiveness of any chemotherapeutical drugs administered [22,24,25]. In such cases, glutamine supplements do not produce the desired effect of strengthening patients’ immunity, and this stimulates the growth of tumours [24]. As a result, it becomes difficult to decide whether or not to prescribe glutamine supplements for such patients.

In the light of the high rates of gynaecological cancer in certain populations, medical practitioners need to be able to adopt alternative treatments for oncological patients, in order to improve their prognosis and quality of life. As such, it is essential to carry out further studies concerning the diet of these patients, with a view to identifying other nutritional substances which could be of benefit. It is also important that suitable diagnostic tests be developed, so that alterations in the transport of amino-acids to cancerous cells can be quickly and easily detected, thus making it easier to decide whether or not glutamine supplements should be administered.


Select your language of interest to view the total content in your interested language
Post your comment

Share This Article

Relevant Topics

Recommended Conferences

  • 6th American Gynecological Surgery Conference September 28-29, 2018 San Antonio | Texas | USA
    September 28-29, 2018 San Antonio, USA
  • World Congress on Fetal and Maternal Medicine October 15-17, 2018 Osaka, Japan Theme: A New Beginning on Fetal, Maternal & Neonatal Medicine
    October 15-17, 2018 Osaka, Japan
  • International Conference on Reproduction and Fertility October 18-19, 2018 Abu Dhabi, UAE
    October 18-19, 2018 Abu Dhabi, UAE

Article Usage

  • Total views: 332
  • [From(publication date):
    specialissue-2017 - Sep 20, 2018]
  • Breakdown by view type
  • HTML page views : 301
  • PDF downloads : 31

Post your comment

captcha   Reload  Can't read the image? click here to refresh

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

bornova escort

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals


[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

gener[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
Leave Your Message 24x7