alexa Obesity and HIV Infection-is there a Role for Bariatric Surgery in Treatment? | OMICS International
ISSN 2155-6113
Journal of AIDS & Clinical Research
Like us on:
Make the best use of Scientific Research and information from our 700+ peer reviewed, Open Access Journals that operates with the help of 50,000+ Editorial Board Members and esteemed reviewers and 1000+ Scientific associations in Medical, Clinical, Pharmaceutical, Engineering, Technology and Management Fields.
Meet Inspiring Speakers and Experts at our 3000+ Global Conferenceseries Events with over 600+ Conferences, 1200+ Symposiums and 1200+ Workshops on
Medical, Pharma, Engineering, Science, Technology and Business

Obesity and HIV Infection-is there a Role for Bariatric Surgery in Treatment?

Shivshankar Seechurn*, Maryam Alfa-Wali, Olubaniyi Ayodeji, Jeremy Thompson and Moses Kapembwa

St. Marys Hospital, London, UK

*Corresponding Author:
Shivshankar Seechurn
St. Marys Hospital, London, UK
Tel: 02033126666
E-mail: [email protected]

Received date: November 25, 2014; Accepted date: December 16, 2014; Published date: December 20, 2014

Citation: Seechurn S, Alfa-Wali M, Ayodeji O, Thompson J, Kapembwa M (2014) Obesity and HIV Infection-is there a Role for Bariatric Surgery in Treatment?. J AIDS Clin Res 5:402. doi:10.4172/2155-6113.1000402

Copyright: © 2014 Seechurn S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Visit for more related articles at Journal of AIDS & Clinical Research


Life expectancy of HIV-infected patients has improved in the recent decade with the use of antiretroviral therapy. Hence, more HIV-infected patients with chronic co-morbidities are being followed by different specialities. Diabetes and obesity are two of the co-morbidities. We looked at the outcome of bariatric surgery for 3 HIV-infected patients. We concluded that bariatric surgery is safe and can reduce pill burden. However, a multi-disciplinary team approach is needed to ensure that the right patients are selected and on-going support available to achieve the best outcome.


Bariatric surgery; HIV patients; Diabetes; Weight loss


Obesity is now a common problem in the UK and HIV-infected patients receiving Antiretroviral Therapy (ART) are not spared. Among patients receiving some antiretroviral medications, in particular, protease inhibitors there is increased risk of serious health problems associated with obesity, such as plasma high cholesterol level and diabetes mellitus. In contrast, some HIV infected patients may present with obesity and cardiovascular risk factors ab initio.

When changes in diet, exercise, and antiretroviral therapy fail to result in weight loss, bariatric surgery is a potential option to reduce obesity for some HIV positive individuals. The most common type of bariatric surgery is gastric bypass, in which stomach size is reduced by 95% and the upper intestine is bypassed. The cost effectiveness of bariatric surgery has been shown in several studies when compared to conventional treatment in large population cohort studies [1]. However, few data are available regarding safety, immunological and virological outcomes of such surgery in HIV-infected patients. We present here clinical outcomes of a series of 3 patients with HIV infection who underwent bariatric surgery for obesity following failure of conventional medical intervention.


3 patients (2 females, 1 male) aged 45 to 66 years, were recruited into the study. Detailed morphometric, immunological and virological data was obtained from the clinic database. All were obese at baseline, median body mass index (BMI) 44.8 and with at least 1 obesity-related comorbidity. Thus, 2 patients had diabetes mellitus and receiving oral hypoglycaemic agents, 2 were hypertensive on treatment and one was normotensive. 2 patients were virally suppressed on standard HAART comprising a combination of at least three drugs, i.e. either 2 Nucleoside Reverse Transcriptase Inhibitors (NRTIs) with 1 non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI) or 2 NRTIs with 1 protease inhibitor (PI), (Table 1). One patient had undetectable viral load in absence of ART pre- and post-operatively. Such cases are sometimes referred to in literature as ‘elite controllers’. All but one individual underwent bariatric surgery at one centre. Data were collected at each clinic visit up to 48 weeks follow-up. The primary outcome was body weight loss. Secondary end points included remission of type 2 diabetes mellitus, hypertension, metabolic syndrome and reduction in use of medications, adverse events and quality of life.

Case 1 Case 2 Case 3
Age 66 39 45
Gender Female Female Male
Ethnicity Black African Black African Black Caribbean
Year of surgery September 2011 September 2012 May 2010
Type of Surgery Gastric Ileo-Bypass Gastric banding Gastric Bypass
Complications None None None
Anti retroviral None Kivexa & Nevirapine Truvada+Boosted Darunavir
CD4 & Viral load
Pre surgery
Post surgery
1158, VL UN
1270(47%), VL UN
590(39%), VL UN
630(42%), VL UN
507, VL UND
570(35%), VL UND
Metformin, Doxazocin Novarapid, Glargine, Lisinopril, Aspirin Indapamide, Ramipril Irbesartan Bisoprolol, Amlodipine Metformin, Gliclazide,Pravastatin,Olistat, Irbesartan, Aspirin, Pioglitazone and Escitalopram
Post Surgery
AdCal D3, Aspirin Only ARVs Pteromax,,aspirin,seleniumL-carnitine ,multivitamins, Pravastatin, vit D,lanzoprazole
Mean BP
Pre Surgery
Post Surgery
Diabetes T2DM on insulin No T2DM
Pre surgery
Post Surgery
Not available 55
Pre Surgery
Post Surgery
107 Kg
Pre Surgery
Post Surgery
Social circumstances Well supported Social isolation,
Marital Disharmony,
Child with learning disability
Anxiety and Depression

Table 1: Cases description.


2 of the three patients (cases 1, 2) experienced weight loss resulting in reduced BMI, which was sustained over 2 years of follow-up. The two diabetic patients became euglycaemic post-operatively (cases 1, 3) and both discontinued oral hypoglycaemic drug therapy including use of insulin in case 1. The latter remains off diabetic therapy after 3 years follow-up. In contrast, case 3 became diabetic again after 2 years of follow-up and was re-started on oral hypoglycaemic therapy. Both patients became normotensive whilst the third remained hypertensive post - surgery.

None of the patients experienced any adverse events post-operatively. All 3 patients have maintained viral suppression (undetectable viral load) with high CD4+ T-lymphocyte cell counts. Plasma cholesterol and triglyceride levels remain unaltered in all patients after 2years of follow-up. Nutritional deficiency has not been detected in any of our patients (Table 1).


The data from this case series lends support to previous reports showing bariatric surgery is beneficial and safe in obese HIV infected patients [2]. Weight loss is the main objective of the surgical intervention and was achieved in 2 of the three cases. However, in terms of overall outcomes, only 1 out of the 3 cases achieved maximum therapeutic benefit from bariatric surgery.

The discrepancy in the magnitude of weight loss among patients post- bariatric surgery is difficult to ascertain. The mechanism by which surgery effects weight loss is thought to involve a permanent loss of appetite brought about by a change in energy balance signals released from the gut. Whether differences exist in physiological compensatory mechanisms between non–responders and responders is unknown. Other plausible explanations for weight loss might include, insulin withdrawal, which in itself may have contributed to pre-operative weight gain as well as social factors. For example, a stable and supportive social background may have played a major role in the outcome post operatively in one of the patients (case 1). The latter observation underscores the need for careful patient selection for this procedure.

Concern has been expressed regarding the effect of rapid weight loss on immunologic function, i.e. decline in the CD4+ T lymphocyte count following bariatric surgery, in particular among patients not receiving HAART. In a couple of reports, the fall in CD4 appeared to coincide with the onset of vitamin B12, folate and vitamin B1 deficiencies both of which are recognised complications of bariatric surgery [3,4]. Our data in the elite controller (Case 1) with the most profound weight loss does not support such observation. This patient maintained CD+ T cell counts in excess of 1,000 cells/ and undetectable plasma viral load despite 34 kg body weight loss.

The resolution of diabetes is almost certainly a consequence of weight loss. However, the exact mechanism by which bariatric surgery induces diabetes remission is still unclear. It is conceivable that gut hormones such as Glucagon-like peptide 1 (GLP-1) acting via the hypothalamus may, improve glycaemic control in part by reducing calorie intake and body weight [5]. In addition, an increase in the colonic Peptide YY (PYY) expression has been shown in mice following gastrointestinal bypass surgery [6]. This gut hormone which normally rises post-prandially in proportion to caloric intake, is also associated with decreased appetite and reduced food intake [7].

One notable feature from our cases is the dramatic reduction in pill burden shown in all 3 patients following bariatric surgery. Whether this outcome confers long term cost-benefit is difficult to predict. Retrospective studies show conflicting data with some showing reduced cost reduction in medications and others demonstrating no sustainability [8].


Bariatric surgery is safe in stable HIV-infected patients receiving multiple drug therapies. Our study also confirms reduction in pill burden as a direct consequence of such procedure. However, not all candidates are suitable to proceed to surgery, and a multi-disciplinary assessment involving psychological, surgical, dietetic and medical teams is needed to select the most appropriate candidates. Such selection should be carried out in an experienced bariatric centre. The choice of surgical procedure must also take into account the individual goals and existing patient co-morbidities. Long-term post bariatric follow-up of HIV positive patients is needed in order to determine why some patients regain weight and other perceived complications of this procedure.


We are grateful to Dr. Andrew Shaw Consultant Physician, NWL Hospitals NHS Trust for providing us details of one of the cases.


Select your language of interest to view the total content in your interested language
Post your comment

Share This Article

Recommended Conferences

  • Global experts meet on STD - AIDS and Infectious Diseases
    May 30-31, 2018 Auckland, New Zealand
  • 6th World Congress on Control and Prevention of HIV/AIDS , STDs & STIs
    August 27-29, 2018 Zurich, Switzerland
  • 6th International Conference on HIV/AIDS , STDs and STIs
    October 29-30, 2018 San Francisco, USA

Article Usage

  • Total views: 13071
  • [From(publication date):
    December-2014 - Mar 25, 2018]
  • Breakdown by view type
  • HTML page views : 9267
  • PDF downloads : 3804

Review summary

  1. sholagreek
    Posted on Feb 16 2017 at 1:02 pm
    My Name is shola greek am from people Join me as i share the wonderful work of Dr EKADOLA how he cured my HIV AIDS Disease, that almost took my life, i have lived with this disease and did all i could be cured but no way.i have been searching out on a cure to terminate my HIV AIDS and on my search i found Dr EKIADOLA help on the lives of many people . and after i wrote to him on how to get a cure, he directed me on the steps and he prepared my herbal medicine and after he sent it to me that after using it, i will be cured, and that was how he sent me my medicine and after using it for some days i was found negative by my test result. why not contact him today on his email: [email protected] and he can still cured..HERPES,H EPATITIS B,CANCER,DIABETICS, his email via ekiadolaherbalh [email protected] whatsapp number +2349057915075
  2. Sandy Fletcher
    Posted on Jan 06 2017 at 2:34 am
    HELLO, i have read testimonies about this great man called Dr. Magana how he helped people to get pregnant and also help people to cure HIV with his herbal medicine, so i decided to give him a try, i am here today to give my own testimony on how this great man helped me to cure my HIV disease and also helped my sister to get pregnant, i just told him and he said he was going to work on it miraculously and in a short period of time i was lifted from these terrible disease. And it took my sister just a week to get pregnant after he was done. Contact this great man and He will help you no matter the the problem you are facing. Email him at [email protected] WhatsApp call +2349051208634.

Post your comment

captcha   Reload  Can't read the image? click here to refresh

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals


[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version