alexa Orbital Secondary Lesion from Renal Cell Carcinoma | Open Access Journals
ISSN: 2472-1220
Journal of Kidney
Like us on:
Make the best use of Scientific Research and information from our 700+ peer reviewed, Open Access Journals that operates with the help of 50,000+ Editorial Board Members and esteemed reviewers and 1000+ Scientific associations in Medical, Clinical, Pharmaceutical, Engineering, Technology and Management Fields.
Meet Inspiring Speakers and Experts at our 3000+ Global Conferenceseries Events with over 600+ Conferences, 1200+ Symposiums and 1200+ Workshops on
Medical, Pharma, Engineering, Science, Technology and Business

Orbital Secondary Lesion from Renal Cell Carcinoma

Federico G1*, Lorenzo S2, Manuele C2, and Bruno Z1

1Unit of Diagnostic Imaging, Università Campus Bio-medico di Roma, Via Alvaro del Portillo, Rome, Italy

2Unit of Otolaryngology, Università Campus Bio-medico di Roma, Via Alvaro del Portillo, Rome, Italy

*Corresponding Author:
Greco Federico
Unit of Diagnostic Imaging
Università Campus Bio-medico di Roma
Via Alvaro del Portillo, 21, 00128, Rome
Tel: +3402650778
E-mail: [email protected]

Received date: February 17, 2017; Accepted date: February 24, 2017; Published date: February 25, 2017

Citation: Federico G, Lorenzo S, Manuele C, Bruno Z (2017) Orbital Secondary Lesion from Renal Cell Carcinoma. J Kidney 3: 140. doi: 10.4172/2472-1220.1000140

Copyright: ©2017 Federico G, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Visit for more related articles at Journal of Kidney


The most common sites of metastasis of renal cell carcinoma are lungs, locoregional lymph nodes, bone and liver. Renal cell carcinoma rarely metastasizes in head and neck sites. We have reported a case of a patient of 47- year-old man who presented with unilateral blepharoptosis and blurred vision due to metastatic renal cell carcinoma to the orbit. The imaging techniques used have been fundamental for the diagnosis, staging and of the choice of the cytological sampling site.


Blepharoptosis; Kidney cancer; Orbital magnetic resonance imaging; Ptosis; Renal cell carcinoma

Short Communication

Kidney cancer constitutes the 2-3% of all malignant tumors in adults and the third most frequent cancer of the urinary tract [1-3]. Male-Female ratio is about two to one (M/F: 2:1), and the mean age at diagnosis is in the early 60 years [2,4].

From 25 to 33% of patients with renal cell carcinoma (RCC) present metastasis at first diagnosis [5]; the most common localizations of metastatic sites are lungs (75%), regional lymph nodes (65%), bone and liver (both 40%). Cases with metastatic localization in the head and neck region are 15% [6].

From 1% to 13% of orbital tumors is metastasis [7]. Studies conducted in different countries demonstrate as from 3% to 10% of the orbital metastasis (OM) derived from the kidney [8-11].

We have presented a case of a 47-year-old patient with unilateral left blepharoptosis and blurred vision, due to an OM from RCC [12].

Brain magnetic resonance imaging (MRI) showed an expansive solid lesion located at the left orbit roof likely to be extraconal bone origin (diameters of 23 × 15 × 25 mm). This lesion was isointense on T1 and T2-weighted images, showing contrast enhancement and intraorbital expansion at the upper-outer quadrant level. The lesions incorporated the lacrimal gland and were not visible cleavage planes from the upper rectus, lateral rectus and the upper eyelid muscle in (Figure 1).


Figure 1: Magnetic resonance imaging: Coronal T2 TSE sequence showing expansive, isointense lesion of probable bone origin with intraorbital growth.

Total body computed tomography (CT) showed in (Figure 2) many secondary mediastinal lymphadenopathies, a partially exophytic lesion located in the upper pole of the left kidney (diameters 72 × 56 × 70 mm) with necrosis in context that marks the upper caliceal group, two metastases at the body and medial arm of the left adrenal gland, a nodulation in the right adrenal gland, loco regional lumbar-aortic lymphadenopathy and many bone metastases in the skeletal portions studied. Consequently, cytology in specimens taken at the lymph-node stations 7 and 11 L through endoscopic ultrasound has placed diagnosis of RCC [12].


Figure 2: Computed tomography: Coronal scan during venous phase of the abdomen (A) and volume rendering reconstruction (B), show expansive lesion, partially exophytic, situated in the upper pole of the kidney with intralesional necrosis.

Orbital metastasis, generally, comes as orbital mass, exophthalmos, lid edema, ptosis, diplopia and/or cranial nerve paralysis [13].

In this case, symptoms such as blurred vision and unilateral ptosis hid a systemic malignancy. MRI and CT are very importance for the diagnosis, the staging of the disease and for the choice of the site where you can make the cytological or histological specimen. In our case the cytology confirmed the diagnosis of renal cell carcinoma [12].


Select your language of interest to view the total content in your interested language
Post your comment

Share This Article

Relevant Topics

Recommended Conferences

  • 16th International Conference on Nephrology
    Nov 02-03, 2017, Atlanta, USA

Article Usage

  • Total views: 386
  • [From(publication date):
    March-2017 - Oct 21, 2017]
  • Breakdown by view type
  • HTML page views : 342
  • PDF downloads :44

Post your comment

captcha   Reload  Can't read the image? click here to refresh

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals


[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version