alexa Paraprotein-related Bleeding as a First Symptom of Multiple Myeloma | OMICS International
ISSN: 2329-6917
Journal of Leukemia
Make the best use of Scientific Research and information from our 700+ peer reviewed, Open Access Journals that operates with the help of 50,000+ Editorial Board Members and esteemed reviewers and 1000+ Scientific associations in Medical, Clinical, Pharmaceutical, Engineering, Technology and Management Fields.
Meet Inspiring Speakers and Experts at our 3000+ Global Conferenceseries Events with over 600+ Conferences, 1200+ Symposiums and 1200+ Workshops on
Medical, Pharma, Engineering, Science, Technology and Business

Paraprotein-related Bleeding as a First Symptom of Multiple Myeloma

Teresa Botín1, Albert Oriol1*, Elisa Orna2and Josep-Maria Ribera1

1Clinical Hematology Service, Institut Català d’Oncologia-Hospital Germans Trias i Pujol, Institut de Recerca contra la Leucèmia Josep Carreras, Badalona, Universitat Autónoma de Barcelona, Spain

2Hemostasis Section, Hematology Laboratory, Hospital Germans Trias i Pujol, Badalona, Spain

*Corresponding Author:
Albert Oriol
Servicio de Hematología Clínica
ICO - Hospital Germans Trias i Pujol
Carretera de Canyet s/n
08916 Badalona, Barcelona, Spain
Tel: 93 497 89 87
Fax: 93 497 89 95
E-mail: [email protected]

Received date: May 06, 2015; Accepted date: May 21, 2015; Published date: May 31, 2015

Citation: Botín T, Oriol A, Orna E, Ribera JM (2015) Paraprotein-related Bleeding as a First Symptom of Multiple Myeloma. J Leuk 3:183.doi:10.4172/2329-6917.1000183

Copyright: ©2015 Oriol A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Visit for more related articles at Journal of Leukemia

Abstract

Specific affinity characteristics of the neoplastic paraprotein have been established as exceptional causes of bleeding in patients with malignant gammopathies. We describe a case in which a relationship between impaired coagulation parameters and the concentration of serum paraprotein, without specific affinity for any coagulation protein, could be established. Alternative causes of bleeding were discarded and a correlation between serum monoclonal paraprotein concentration and activated partial thromboplastin time was established.
Multiple myeloma treatments achieved minor responses only, but were otherwise associated with partial improvement in coagulation parameters and, most importantly, control of the bleeding episodes. The interference in the coagulation process appeared to be non-specific and related to paraprotein concentration only but was not related to hyperviscosity. The case emphasizes the need to suspect of atypical effects of paraproteinemia in patients with monoclonal gammopathy of unknown significance and eventually to treat the underlying plasma cell dyscrasia if symptoms, like severe bleeding, justify that intervention.

Abstract

Specific affinity characteristics of the neoplastic paraprotein have been established as exceptional causes of bleeding in patients with malignant gammopathies. We describe a case in which a relationship between impaired coagulation parameters and the concentration of serum paraprotein, without specific affinity for any coagulation protein, could be established. Alternative causes of bleeding were discarded and a correlation between serum monoclonal paraprotein concentration and activated partial thromboplastin time was established.

Multiple myeloma treatments achieved minor responses only, but were otherwise associated with partial improvement in coagulation parameters and, most importantly, control of the bleeding episodes. The interference in the coagulation process appeared to be non-specific and related to paraprotein concentration only but was not related to hyperviscosity. The case emphasizes the need to suspect of atypical effects of paraproteinemia in patients with monoclonal gammopathy of unknown significance and eventually to treat the underlying plasma cell dyscrasia if symptoms, like severe bleeding, justify that intervention.

Keywords

Multiple myeloma; Bleeding manifestations; Symptomatic paraproteinemia

Case report

Patients with Monoclonal Gammopathy of Undetermined Significance (MGUS), Waldenstrom's Macroglobulinemia (WM), Amyloidosis (AAL) or Multiple Myeloma (MM) may present both thrombotic and bleeding complications. Bleeding is commonly associated with treatment or disease related thrombocytopenia [1] while thrombosis may be related to paraneoplastic phenomena [2,3] or to treatment, as is the case with thalidomide derivatives and high dose dexamethasone [4-7]. Acquired von Willebrand disease has been described occasionally in MM and AAL but rarely induce clinically relevant bleeding [8,9]. Infrequent hemorrhagic events related to the presence of monoclonal immunoglobulins can range from skin hemorrhages to a life threatening gastrointestinal bleeding [2,3]. Specific affinity characteristics of the paraprotein with coagulation factors or platelet surface proteins have been established in some cases of severe bleeding associated to a monoclonal gammopathy [10,11].

We describe a case of a patient in which a MGUS was detected during the study of an episode of uncontrolled hematuria. A relationship between impaired coagulation parameters and serum paraprotein concentration could be established.

A 72- year-old man with a prior history of diabetes, hyperuricemia and dyslipidemia, was admitted because of the acute onset of severe and uncontrolled hematuria. The initial hematology values at first admission were leukocytes 5.8 × 109/L, hemoglobin 133 g/L, platelets 206 × 109/L, activated Partial Thromboplastin Time (aPTT) ratio was 1.95 and Prothrombin Time (PT) ratio 1.4, fibrinogen was 426 mg/dL. After persistent bleeding, the patient required of the transfusion of six units of packed red blood cells for hemodynamic stabilization. A diagnostic procedure was performed. Ultrasound imaging of the urinary system did not find abnormalities in kidneys, bladder or prostate. A cystoscopy did not identify specific lesions but a diffuse bleeding, a random bladder biopsy was negative, an arteriography and a CT scan failed to identify anatomic lesions as a cause of bleeding. Both bladder and prostatic biopsies were negative for malignancy or amyloidosis. Hematuria was attributed to a coagulation disorder and was not controllable with fibrinogen and activated factor VII. Finally, the patient required of the urgent embolization of the hypogastric artery. Despite this procedure control of the bleeding episode was temporary and successive bleeding recurrences occurred.

The complete evaluation of hemostasis gave the following results: aPTT ratio 1.95 and TP ratio 1.44. Thrombin time and reptilase time within normal limits. Klauss quantification of fibrinogen within normal limits. The aPTT and PT did not correct after incubation for 120 min at 37°C in mixture tests. Determination of coagulation factors did not detect any deficiency, factor II was 107.7%, factor V 90%, factor VII 85.5%, factor X 131.2%, factor VIII 190.4%, factor IX 177.1%, factor XI 108.3% and factor XII 157.6% (normal limits over 70% for all factors). Results were not modified after mix with normal plasma for 120 min at 37°C. Determinations of lupus anticoagulant, anti cardiolipin and anti β2 glycoprotein antibodies were negative. The study of von Willebrand factor was normal (von Willebrand antigen 185.3% and activity 125.4%, normal limits 60-160%). Potential platelet dysfunctions were also considered, PFA-100 was normal for both Col/Epinephrin and COL/ADP tests (142 and 111 seconds respectively with normal limits <165” and < 118”).

The patient was screened for occult autoimmune diseases, neoplasia and antibodies against clotting factors with negative results except for a protein electrophoresis that detected the presence of a monoclonal IgG lambda monoclonal component (MC). The MC quantification by serum electrophoresis was 17.34 g/L, a bone marrow aspirate demonstrated a 10% infiltration by atypical plasma cells. Congo Red stain in bone marrow samples was negative. Calcemia, renal function and skeletal X-ray bone survey were negative. Anemia was clearly related to the bleeding episodes and consequently only a diagnosis of “smoldering” multiple myeloma could be established.

The inadequate control of bleeding and the absence of alternative explanations to justify the observed coagulation abnormalities prompted the treatment of MM, that was started with corticosteroids and melphalan (MP). Standard treatment including bortezomib was dismissed because of the risk of thrombocytopenia [1]. After six cycles of melphalan and prednisone the patient presented only a minor serological response (Figure 1), notably aPTT had partially improved and, most importantly, bleeding episodes had not recurred (Figure 1).

leukemia-partial-thromboplastin-time

Figure 1: Evolution of seric monoclonal component (sMC), activated partial thromboplastin time (aPTT) and prothrombin time (PT) in the patient. Asterisks represent bleeding episodes and black arrows represent treatment periods with melphalanprednisone (first line), melphalan-prednisone and bortezomib (second line) and lenalidomide-dexamethasone (third line).

In the absence of bleeding and anemia, lack of symptoms or signs of active myeloma and no further improvement with MP, treatment was discontinued. During the treatment-free interval the MC concentration increased progressively and this was associated with a parallel prolongation of aPTT (Figure 1). Four months after MP discontinuation, a bone marrow aspirate reassessment revealed a 18% infiltration by atypical plasma cells, serum monoclonal component had raised to 22 g/L and aPTT had increased to 42 seconds. A decision was being made to start second line treatment with MP and bortezomib when the patient suffered an episode of phimosis and a minor surgical intervention was urgently needed. The intervention was associated with an important episode of local bleeding and extensive scrotal hematoma that could be resolved. Coagulation at that time showed a PT ratio 1.44 and a 1.36 aPTT ratio. The patient received treatment with MP and bortezomib but required the interruption of therapy after 8 cycles because of grade 2 bortezomib-related neuropathy. Again, partial improvement of paraproteinemia was associated with a partial improvement of aPTT and absence of further bleeding episodes. Again, the patient presented slow biological progression with slowly increasing levels of monoclonal component and aPTT prolongation after treatment interruption and finally presented two minor episodes of epistaxis that prompted the initiation of third line treatment with lenalidomide and dexamethasone. Once again a correlation between reduction of paraprotein and correction of aPTT has been observed despite the instauration of enoxaparin prophylaxis along with lenalidomide treatment. Figure 1 illustrates the relationship between the aPTT ratio and MC during the patient clinical evolution.

Paraproteinemias have been associated with thrombotic mechanisms such as hypofibrinolysis, increased blood viscosity, production of autoantibodies, procoagulant effects of inflammatory cytokines or resistance to activated protein C [5.6.12]. Myeloma treatment with immunomodulatory drugs is associated with thrombotic events and requires prophylactic treatment with heparin or aspirin [13]. Bleeding events in patients with plasma cell dyscrasias not related to thrombocytopenia are less frequent [2,3]. Some pathophysiological mechanisms include the interference of circulating monoclonal proteins with platelet function and coagulation factors [9-13] or acquired von Willebrand disease [8]. The detection of these abnormalities may be casual or occasional laboratory findings detected following surgery or trauma complications.

The case we described showed no acquired von Willebrand disease or plasma hyperviscosity, and specific coagulation tests repeatedly failed to find abnormal levels of factors or factor inhibitors. Amyloid was investigated in the bone marrow with negative results but was not investigated in subcutaneous fat tissue. Nevertheless factor X was normal, while it is usually decreased in primary amyloidosis. Moreover the patient did not present any symptom or sign suggesting systemic amyloidosis, renal function was normal as it was cardiac function, including ECG and echocardiographic results. The association between plasma levels of paraprotein and prolonged clotting times, particularly aPTT, suggested a direct interference of monoclonal component in the coagulation process. Interferences with platelet aggregation were specifically excluded. Peculiarly, coagulation interference appeared to be non-specific and related to paraprotein concentration but was not otherwise associated to hyperviscosity as may have been postulated with higher protein levels, particularly if the IgM type, a relatively frequent phenomenon in WM [14]. The possibility of a monoclonal protein interference with the polymerization of fibrin monomers, resulting in an acquired dysfibrinogenemia was excluded by the normality of thrombin time and reptilase tests. In any case, response to empirical treatment, subsequent relapses and treatment rechallenges clearly established the correlation between MM and the coagulation disorder and emphasizes the need to suspect such associations when alternative causes of coagulopathy are discarded. In that case instauration of MM treatment seemed reasonable despite the absence of the MM symptoms that typically indicate the need for therapy [15].

In conclusion, the rare case presented, highlights the need to be alert to atypical consequences of paraproteinemia in patients with MGUS or smoldering MM. In those unusual circumstances, the treatment of the underlying gammopathy should be considered as an exceptional measure. In our case, MM treatment proved to be the only measure to control bleeding episodes, despite the patient having a minor response to treatment only.

References


Select your language of interest to view the total content in your interested language
Post your comment

Share This Article

Relevant Topics

Article Usage

  • Total views: 13391
  • [From(publication date):
    June-2015 - Jul 17, 2018]
  • Breakdown by view type
  • HTML page views : 9505
  • PDF downloads : 3886
 

Post your comment

captcha   Reload  Can't read the image? click here to refresh

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

+1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
Leave Your Message 24x7