Reach Us +44-7482877605
Parvimonas Micra Bloodstream infection in a Patient with Oral Mucositis

Research and Reports in Medical Sciences
Open Access

Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.
  • Case Report   
  • Res Rep Med Sci 2017, Vol 1(1): 102

Parvimonas Micra Bloodstream infection in a Patient with Oral Mucositis

Giuseppe Tonnara1*, Giuseppe Ferdinando Colloca1 and Vincenzo Valentini2
1Geriatric Department, Fondazione Policlinico A.Gemelli, Rome, Italy
2Radiation Oncology Department, Catholic University of Sacred Heart, Rome, Italy
*Corresponding Author: Giuseppe Tonnara, Geriatric Department, Fondazione Policlinico A.Gemelli, Rome, Italy, Tel: +3906 6270937, Email: [email protected]

Received Date: Nov 04, 2017 / Accepted Date: Nov 21, 2017 / Published Date: Nov 26, 2017


Parvimonas micra, a normal constituent of oral flora, is an opportunistic pathogen more commonly associated with oral infections after dental procedures. Here we report a fatal case of sepsis in a patient suffering from oral mucositis secondary to radiochemotherapy for rhynopharynx carcinoma. This case highlights the importance of oral mucositis as an underestimated infectious risk factor

Keywords: Parvimonas micra; Bloodstream infection; Cancer; Mucositis; Radiochemotherapy


Mucositis is a disabling toxicity related to head and neck cancer (HNC) treatment [1]. As well as negatively affecting nutritional intake, quality of life, radiotherapy (RT) and/or chemotherapy (CT) delivery, it is associated with a higher risk of local and systemic infections which can be life-threatening [2]. Local infections are often sustained by Candida species and Herpes Simplex virus; systemic infections, are commonly due to Candida species, gram-negative bacteria and alphahemolytic streptococci [3].

Formerly known as Peptostreptococcus micros or Micromonas micros, the Gram-positive anaerobic cocci currently classified as Parvimonas micra (P. micra) are normal constituent of oral and gastrointestinal flora. While there is broad evidence to support the role of P. micra in periodontal and other oral infections, those outside the oral cavity have been underreported [4]. It is worthy to note that dental procedures are the main risk factor for P. micra infection; no case has been reported following radiochemotherapy (RT-CT) for HNC or secondary to oral mucositis [5].

We report a case of P. micra lung and, subsequently, bloodstream infection in a patient affected by rhynopharynx carcinoma treated with RT-CT.

Case Report

A 71-year-old Italian man presented with 2-day history of fever without any other acute complaint. His clinical history was significant for Parkinson disease from 7 years and long-standing hypertension. He had been diagnosed with high-grade, locally invasive rhynopharingeal carcinoma in September 2016. Patient underwent RT-CT with intensity-modulated technique and concomitant weekly cisplatin infusion through peripherally inserted central venous catheter (PICC) (after first cycle he was shifted on carboplatin infusion for kidney toxicity). The total RT dose was 70.2 Gy with a daily fraction of 1.8 Gy; RT volumes were tumor, pathological nodes and elective drainage nodes. Treatment was complicated with grade 2 oral mucositis and worsening of motor compensation.

Follow-up examinations revealed a partial response of the nasopharyngeal mass and the presence of a right iliac wing secondary lesion. Accordingly, patient was started with weekly infusion of carboplatin and cetuximab in May 2017. CT was soon complicated by grade 3 fatigue with consequent reduced mobility and grade 3 oral mucositis.

On examination, the patient was in poor clinical conditions but he denied any acute distress; vital parameters were as follows: temperature 37.9°C, blood pressure 120/70 mmHg, pulse rate 100 bpm, oxygen saturation 96% on room air. There was no spinal tenderness or other localizing sign; his heart sounds were dual and lungs were clear with good air entry on auscultation; abdominal exam revealed no abnormalities; there was no erythema or edema at the lower limbs.

Laboratory studies demonstrated a leukocyte count of 12.06 × 103/mL, a procalcitonin (PCT) of 0.31 ng/mL and a C-reactive protein (CRP) elevated at 183.4 mg/L; renal and hepatic tests were within normal; blood gas analysis documented a type 1 respiratory failure (PaO2 59 mmHg, PaCo2 33 mmHg). Chest-x-ray showed no abnormalities. Blood samples for culture were obtained from one peripheral venipuncture site and one PICC.

Assuming an atypical lung infection, the patient was started on cefepime 1 g b.i.d. and azithromycin 500 mg q.d. Three days into admission, with progressive worsening of respiratory failure, both blood samples grew P. micra and procalcitonin increased up to 12.07 ng/ml. After infectious disease specialist consultation, the patient was shifted on ampicillin/sulbactam and vancomycin.

Despite treatment, the patient died from progressive respiratory and multiorgan failure four days from admission.


As this case shows, P. micra lung infection can be rapidly progressive and even fatal in at-risk patients. P. micra is an opportunistic pathogen which more commonly causes oral infections after dental procedures. Central nervous system, thorax, abdomen, genitourinary and soft tissues infections usually develop with predisposing conditions such as immunodeficiency, diabetes, steroid treatment and neoplasia. Multiple risk factors appear to be involved in our case: neoplasia, chemotherapy in progress, severe mucositis and consequent malnutrition, Parkinson disease and reduced mobility. It is likely that the interplay of these risk factors has been decisive in determining the negative outcome of therapies.

P. micra may cause different thoracic infections: pneumonia, lung abscess, pleuritic empyema, mediastinitis. In the case of pneumonia and lung abscess, the most common thoracic infections, clinical course is usually indolent but more aggressive presentation may occur as our case showed. It is important to recognize that chest-x-ray findings may be elusive and, as a matter of fact, we report a case in which thoracic imaging showed no abnormalities.

P. micra pneumonia should be treated with either clindamycin or a combination of penicillin and a β-lactamase inhibitor; it is recommended that such regimen lasts 2-4 weeks, depending response. In the case of a lung abscess, treatment should not withheld for up to 3 months or until the chest imaging clears, though treatment can be shortened with proper surgical drainage [6].

Even more important in our opinion, this case highlights the importance of oral mucositis as an underestimated infectious risk factor. While there is no direct cause-effect relationship between P. micra infection and cetuximab therapy, it should be appreciated that evidence suggests a higher infectious risk, particularly of pneumonia, in older HNC patients treated with cetuximab [7]. This drug is not immunosuppressant per se but in combination with platinum-based CT it can increase the frequency of mucositis and severe neutropenia.

To date, no evidence-based protocol has been developed for prevention and treatment of oral mucositis and this is particularly troublesome for HNC patients who face a substantial risk of severe mucositis. MASCC/ISO guidelines for oral mucositis recommend benzydamine mouthwash to prevent oral mucositis in patients with HNC receiving moderate dose radiation therapy (up to 50 Gy), without concomitant chemotherapy; the panel suggests oral care protocols, low-level laser therapy and systemic zinc supplements to prevent oral mucositis in patients with HNC receiving moderate dose radiation therapy (up to 50 Gy), without concomitant chemotherapy. MASCC/ISO guidelines suggest only a symptomatic treatment for oral mucositis, with morphine or doxepine mouthwash. It is therefore evident that currently available evidence for preventing and treating oral mucositis in patients with HNC is insufficient. We advocate more studies be conducted on this field in the future.


Citation: Tonnara G,Colloca GF,Valentini V (2017) Parvimonas Micra Bloodstream infection in a Patient with Oral Mucositis. Res Rep Med Sci 1: 102.

Copyright: © 2017 Tonnara G, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Select your language of interest to view the total content in your interested language

Post Your Comment Citation
Share This Article
Article Usage
  • Total views: 2285
  • [From(publication date): 0-2017 - Nov 20, 2019]
  • Breakdown by view type
  • HTML page views: 2156
  • PDF downloads: 129