Pharmaceutical Application of Carbon Nanotubes Synthesized by Flame Fragments Deposition Method
Received Date: Nov 14, 2017 / Accepted Date: Nov 15, 2017 / Published Date: Nov 20, 2017
One of the most important applications of Carbon Nanotubes (CNTs) is their using in pharmacy as an excellent vehicle for drug delivery. Different techniques are used to synthesize CNTs. CNTs are used in medicine as a carries for drugs such as antibacterial to improve the penetrating capacity of drugs and reduce toxicity of using anticancer drug directly without carrier. In our research laboratory CNTs were synthesized by using different carbon sources including date palm seeds, alcohols and natural gas. Synthesizing of CNTs from natural gas by Flame Fragments Deposition (FFD) may be considered as a clean technique and more suitable to use its yield in medical and pharmaceutical applications due to the absence of using any type of catalysts in this technique. Synthesized CNTs showed a high capacity for adsorption.
One of the most important applications of Carbon Nanotubes (CNTs) is their using in pharmacy as an excellent vehicle for drug delivery. Different techniques are used to synthesize CNTs. CNTs are used in medicine as a carries for drugs such as antibacterial to improve the penetrating capacity of drugs and reduce toxicity of using anticancer drug directly without carrier .
In our research laboratory CNTs were synthesized by using different carbon sources including date palm seeds , alcohols [3,4] and natural gas [5,6]. Synthesizing of CNTs from natural gas by Flame Fragments Deposition (FFD) may be considered as a clean technique and more suitable to use its yield in medical and pharmaceutical applications due to the absence of using any type of catalysts in this technique. Synthesized CNTs showed a high capacity for adsorption .
Sulfamethoxazole (SMX) is an antibiotic, used to treat a variety of bacterial infections. Adsorption is done by using SMX solutions with two concentrations 50 ppm and 100 ppm was prepared. 25 ml of SMX solutions of different concentrations were respectively stirred with 0.02 g MWNTs for 2 hours at 25°C. After the adsorption experiment, the samples were filtrated by filter paper, then their clear solutions obtained were measured by spectrophotometry at 271 nm  for determination of sample concentrations.
SEM was used to determine the morphology of CNTs and to obtain information about the dimensions of nanotubes. FT-IR spectroscopy was used to obtain information about the location of functionalized groups of CNTs. The efficiency of CNTs in drug delivery was measured by adsorption of SMX on CNTs. Figure 1 shows the SEM images of synthesized CNTs from natural gas by using CVD method. These images show obtain high density of MWCNTs as agglomerates and also obtain amorphous carbon, and the elements are not found in this sample because the process of synthesis is without catalyst.
FT-IR spectroscopy of CNTs provided information of functionalized groups as shown in Figure 2. There were many peaks in rang 1713-989 cm-1. These bands of spectrum are related to a carbonyl group, amine group and olefin groups as well as bands between 1412 and 1000 cm-1 which are finger prints. This mean, the synthesized CNTs had no carboxyl and amine groups.
The adsorption efficiency of SMX on CNTs was compared for two concentrations of SMX as shown in Table 1. The higher adsorption efficiency was obtained when the concentration of SMX was high, along with increase of SMX concentration. The adsorption efficiency increased as well as, the loading quantity increased from 9.9875 mg/g to 55.357 mg/g when the concentration of SMX increases from 50 to 100 ppm. The adsorption efficiency commonly based on the Van der Waals interaction, π-π staking interaction, electrostatic adsorption and simple hydrophobic interaction in their structure between CNTs and SMX. Generally, the drug loading efficiency of CNTs can be increased when CNTs are functionalized because of supply more adsorption and binding sites for SMX [9,10].
|Q (mg/g)||Au||As||Cu (ppm)||Cs (ppm)|
Table1: The adsorption of SMX on carbon nanotubes.
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Citation: Hussein FH, Hasan BS, Mageed MB, Nafaee ZH, Mohammed GJ (2017) Pharmaceutical Application of Carbon Nanotubes Synthesized by Flame Fragments Deposition Method. J Environ Anal Chem 4: e115. Doi: 10.4172/2380-2391.1000e115
Copyright: © 2017 Hussein FH, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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