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Journal of Bioequivalence & Bioavailability
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Pharmacokinetics and Tolerability of Single and Multiple Doses of Desvenlafaxine in Healthy Korean Subjects

Liang Y1*, Qiu R2, Kim S3, Jang IJ3, Lee WS4, Plotka A5 and Nichols A5

1Pfizer Inc., Groton, CT, USA

2Pfizer Inc., Cambridge, MA, USA

3Seoul National University College of Medicine and Hospital, Seoul, Republic of Korea

4Pfizer Korea Inc., Seoul, Republic of Korea

5Pfizer Inc., Collegeville, PA, USA

Corresponding Author:
Liang Y MS
Senior Associate, Pfizer, 445 Eastern
Point Road-MS8260-2241, Groton, CT 06340, USA
Tel: 860 441 6952
E-mail: [email protected]

Received Date: November 11, 2016; Accepted Date: January 10, 2017; Published Date: January 27, 2017

Citation: Liang Y, Qiu R, Kim S, Jang IJ, Lee WS, et al. (2017) Pharmacokinetics and Tolerability of Single and Multiple Doses of Desvenlafaxine in Healthy Korean Subjects. J Bioequiv Availab 9:341-345. doi: 10.4172/jbb.1000322

Copyright: © 2017 Liang Y, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Background: Racial and ethnic variations in CYP enzyme polymorphisms have been associated with population differences in drug metabolism. This study evaluated the pharmacokinetics of single- and multiple-dose desvenlafaxine in healthy Korean subjects.

Methods: This randomized, double-blind, placebo-controlled, study enrolled 38 healthy Korean adults (aged 18 to 55 years). Subjects received single oral doses of placebo or desvenlafaxine (administered as desvenlafaxine succinate) 50, 100, or 200 mg on day 1, followed by 5 days of once daily dosing on days 4 to 8. Blood samples were collected pre-dose and over 72 h post-dose on days 1 and 8. Plasma desvenlafaxine concentrations were measured using a validated high-performance liquid chromatography tandem mass spectrometry and pharmacokinetic parameters were calculated using non-compartmental method. Tolerability was assessed through adverse event reporting.

Results: For both single-and multiple-dose desvenlafaxine, peak plasma concentration and area under the concentration-time curve increased approximately linearly with dose. For the 4-fold increase in dose from 50 mg to 200 mg desvenlafaxine, area under the concentration-time curve from time 0 extrapolated to infinite time for singledose and area under the concentration-time curve from time 0-24 h for multiple-dose administration increased 4.3- and 4.1-fold, respectively; peak plasma concentration values increased 4.5- and 4.3-fold, respectively. Mean apparent half-life ranged from 10.75-13.49 h across all doses following single and multiple dose administration. Accumulation ratios for area under the concentration-time curve ranged from 1.478 to 1.669 (peak plasma concentration, 1.488- 1.578). No serious or severe adverse events were reported.

Conclusion: The pharmacokinetics of multiple-dose desvenlafaxine 50-200 mg was linear and was able to be predicted from single-dose pharmacokinetics in Korean subjects. Pharmacokinetic parameters were similar to values previously observed in other racial/ethnic populations. There were no new safety findings for desvenlafaxine.


Desvenlafaxine; Antidepressive agents; Pharmacokinetics; Cytochrome P-450 CYP2D6


Desvenlafaxine is a Serotonin-Norepinephrine Reuptake Inhibitor (SNRI) with demonstrated efficacy for improving symptoms of Major Depressive Disorder (MDD) in adults over the dose range of 50 mg/d to 400 mg/d [1-10]. Desvenlafaxine (administered as desvenlafaxine succinate) is approved at the 50 mg/d and 100 mg/d doses in more than 30 countries; the recommended therapeutic dose is 50 mg/d [11]. The pharmacokinetic profile of single-dose and multiple-dose desvenlafaxine, examined in multiple studies [12-16], was found to be linear and dose-proportional over the dose range of 50 mg/d to 600 mg/d [15,16].

Pharmacokinetic studies of desvenlafaxine have been largely based on Caucasian or African American populations [12-17]. However, population differences in drug metabolism linked to variations in the incidence of hepatic Cytochrome P450 (CYP) enzyme polymorphisms have been observed for some drugs [18-21]. For example, CYP2D6 based drug metabolism can vary substantially between East Asian (including Chinese, Japanese and Korean) and Caucasian populations [18,20,22,23]. However, desvenlafaxine is primarily eliminated via phase II glucuronidation and renal excretion, with minimal phase I CYP3A4 hepatic metabolism [11,24]. Race differences in desvenlafaxine pharmacokinetics therefore are not predicted by its metabolic profile. Analysis of desvenlafaxine pharmacokinetics has been carried out in non-US and European populations and no notable differences were observed between racial groups in those studies [25,26]. Desvenlafaxine has been in development for the MDD indication in Korea, and the current study was therefore designed to assess desvenlafaxine pharmacokinetics in a Korean population. The objective of this study was to evaluate single- and multiple-dose desvenlafaxine pharmacokinetics, safety, and tolerability in healthy Korean adults.


Study design

This was a randomized, double-blind, placebo-controlled, parallel-group study of desvenlafaxine pharmacokinetics following single oral doses and after 5 days of once daily dosing in healthy Korean subjects. Desvenlafaxine dose levels of 50 mg, 100 mg, and 200 mg were evaluated. Subjects were randomly assigned in a 5:1 ratio (desvenlafaxine: placebo) at each of the 3 doses. The study was conducted at Seoul National University Hospital, Seoul, Republic of Korea between November and December 2011, and was in compliance with the ethical principles of the Declaration of Helsinki and the International Conference on Harmonization Good Clinical Practice Guidelines. The site’s institutional review board (IRB) provided protocol approval and study oversight (IRB clearance number, H1109023377). Written informed consent was obtained from all subjects before screening.


The study enrolled male and non-pregnant/non-lactating female adults (aged 18-55 years) with a body mass index of 17.5-30.5 kg/m2 and total body weight greater than 50 kg. All subjects were Asian with a racial designation of Korean. Enrolled subjects were healthy, based on medical history, physical examination, vital signs, clinical laboratory test results, and 12-lead Electrocardiogram (ECG), and smoked no more than 5 cigarettes per day (or the equivalent tobacco- or nicotine-containing products). Subjects were excluded from the study if they had evidence or history of clinically significant hematologic, renal, endocrine, pulmonary, gastrointestinal, cardiovascular, hepatic, psychiatric, neurologic, or allergic disease; any condition possibly affecting drug absorption (e.g. gastrectomy); drug abuse; or regular alcohol consumption exceeding 14 drinks/week for females or 21 drinks/week for males within 6 months of screening. Use of any of the following drugs was prohibited: investigational drugs within 30 days or 5 half-lives (whichever was longer) before day 1; prescription or non-prescription drugs (except acetaminophen/paracetamol) and dietary supplements within 7 days (or 5 half-lives) before day 1; and herbal supplements and hormonal methods of contraception or hormone therapy within 28 days.

Study procedures

Each subject received a single oral dose of desvenlafaxine or placebo on study day 1, and then daily dosing on days 4 through 8. On day 1, subjects were dosed after an overnight fast of at least 8 h. On day 4 through 7, subjects received a breakfast approximately 30 minutes before study drug administration. On the morning of day 8, subjects received the last dose of study drug after an overnight fast of at least 8 h. Serial blood samples (4 mL) for pharmacokinetic analysis were collected in tubes containing potassium ethylenediamine tetraacetic acid before (pre-dose), and (0.5, 1, 2, 4, 6, 8, 10, 12, 16, 24, 36, 48, 72) h after study drug administration on days 1 and 8. Samples were centrifuged at approximately 1700 × g for 10 min at 4°C and plasma was stored at approximately -20°C within 1 h of collection, and stored at -20°C ± 5°C until analysis, within 77 days.

Bioanalytical methods

Plasma desvenlafaxine was quantitated using a protein precipitation extraction. Plasma samples were analyzed for desvenlafaxine concentrations at WuXi AppTec (Shanghai, People’s Republic of China) using validated high-performance liquid chromatographic tandem mass spectrometry using nadolol as an internal standard and venlafaxine and O-desmethylvenlafaxine (the free base of desvenlafaxine) as reference standards. The peak area ratios of internal and reference standards were determined using Analyst® Version 1.5.1 or Version 1.4.2 (Applied Biosystems, Foster City, CA, USA) and desvenlafaxine concentrations were calculated by Watson™ LIMS Version (Thermo Fisher Scientific, Philadelphia, PA, United States). Calibration standard responses were linear over the range of 2.00 ng/mL to 500 ng/mL. The lower limit of quantification (LLOQ) for desmethylvenlafaxine was 2.00 ng/mL. Samples with concentrations below the LLOQ were set to 0 ng/mL.

Between-day assay accuracy (percent relative error) for quality control (QC) concentrations, ranged from -1.1% to 1.8% for the low (5.00 ng/mL), medium (45.0 ng/mL), high (375 ng/mL), and diluted (2500 ng/mL) QC samples. Assay precision, expressed as the between-day percent coefficients of variation (%CV) of the mean estimated concentrations of QC samples was ≤ 3.9% for the low, medium, high, and diluted concentrations.

Pharmacokinetic analyses

Desvenlafaxine plasma concentrations were analyzed using noncompartmental analysis of concentration versus time data. Peak concentration (Cmax) and time to Cmax (Tmax) were observed directly from the data. Total area under the drug concentration-time curve from time 0 to the time of the last quantifiable concentration (AUClast) and from time 0-24 h (AUC24) were estimated using the linear/log trapezoidal method. AUC from time 0 extrapolated to infinite time (AUC) was calculated based on AUClast + (Clast */kel), where Clast * is the predicted plasma concentration at the last quantifiable time point estimated from the log-linear regression analysis and kel is the terminal phase elimination rate constant. The terminal-phase elimination half-life (t1/2) was calculated as t1/2=ln (2)/kel. Apparent oral dose clearance (Cl/F) was estimated as the day 1 dose/AUC and day 8 dose/ AUC24. Apparent volume of distribution for the terminal disposition phase (Vz/F) was calculated as the ratio of Cl/F to kel. The observed accumulation ratio for AUC (Rac) was defined as the ratio of day 8 AUC24 to day 1 AUC24 and the accumulation ratio for Cmax (Rac, Cmax) was the ratio of day 8 Cmax to day 1 Cmax. The parameters of AUC, t1/2, Cl/F, and Vz/F were reported only if a well-characterized terminal phase, defined as at least 3 data points with a goodness-of-fit statistic for the log-linear regression (r2) ≥0.9 and a span ratio (duration over which t½ was assessed, divided by the t½ estimate) ≥2, was observed. The attainment of steady-state was assessed using a median plot of the pre-dose concentrations on days 7, 8, and 9.

Safety assessments

Safety and tolerability assessments included Adverse Event (AE) reports, clinical laboratory evaluations (blood chemistry, hematology, and urinalyses), physical examination, vital sign measurements, and 12-lead ECGs. Safety assessments were made at baseline, at scheduled intervals post-dose, and at final study evaluation (72 h after final dose). Adverse events were monitored throughout the study period and reported using terminology from the Medical Dictionary for Regulatory Activities (version 14.1). Treatment-emergent AEs (TEAEs), defined as AEs that occurred or increased in severity following the start of treatment, were tabulated by dose. Vital signs, ECGs, and laboratory test results were evaluated for potential clinical importance using predetermined criteria. All subjects who received at least 1 dose of study medication were included in safety analyses (Supplementary Figure 1).

Statistical analysis

Plasma desvenlafaxine concentrations were summarized by dose and sampling time; pharmacokinetic parameters were summarized descriptively by dose. Summary statistics for AUC0-24, AUC, Cmax, t1/2, CL/F, Vz/F, and Rac included arithmetic mean, median, Coefficient of Variation (CV%), standard deviation, minimum, maximum, and geometric mean (except for t1/2); Tmax was summarized using median, minimum, and maximum. Relationships between pharmacokinetic parameters and dose were assessed visually using plots of dose-normalized parameters vs. dose for individual subject values and geometric means. No formal inferential statistics were applied to pharmacokinetic or safety data.


Study population

A total of 38 subjects were randomly assigned; 37 subjects (24 male, 13 female) received at least 1 dose of study drug and comprised the safety population. Demographic and baseline characteristics were similar between treatment groups (Table 1). One subject chose to discontinue the study after receiving desvenlafaxine 100 mg on day 1 and was excluded from pharmacokinetic analyses. Pharmacokinetic data were analyzed for 30 subjects who received desvenlafaxine and completed the study; subjects assigned to placebo (n=6) were not included in the pharmacokinetic analysis.

  Desvenlafaxine Dose Group Placebo
50 mg (n=10) 100 mg (n=11) 200 mg (n=10)
Age (year)
Mean (SD) 26.7 (4.6) 26.2 (4.0) 26.7 (7.5) 24.2 (3.9)
Range 21-36 21-32 21-46 20-31
Sex, n (%)
Female 2 (20) 6 (55) 2 (20) 3 (50)
Male 8 (80) 5 (45) 8 (80) 3 (50)
Height (cm)
Mean (SD) 170.1 (5.6) 167.1 (8.7) 172.9 (7.8) 167.3 (6.3)
Weight (kg)
Mean (SD) 62.4 (8.5) 63.6 (7.5) 63.9 (6.8) 64.8 (9.4)
BMI (kg/m2)
Mean (SD) 21.5 (2.0) 22.7 (1.4) 21.4 (1.9) 23.1 (2.7)

Table 1: Baseline demographic and clinical characteristics, safety population.

Data from 2 subjects were removed from the pharmacokinetic summary: on day 1, 1 subject taking desvenlafaxine 200 mg was excluded because of vomiting within 2 h after dosing, and on day 8, 1 subject taking desvenlafaxine 100 mg was excluded for low or undetectable plasma desvenlafaxine concentrations. The reason for anomalous concentrations could not be determined.


Figure 1 shows median plasma concentrations of desvenlafaxine over time after administration of single and multiple doses of desvenlafaxine 50 mg, 100 mg, and 200 mg. Median Tmax ranged from 4.00 (desvenlafaxine 50 mg) to 6.00 h (desvenlafaxine 200 mg) after single dose desvenlafaxine and was 4.00 h post-dose for each desvenlafaxine dose after 5 days of daily dosing. Steady-state exposures appeared to be reached after 4 days of daily dosing (day 7), based on similar median trough (pre-dose) concentrations on days 7 to 9.


Figure 1: Mean ± SD desvenlafaxine plasma concentration vs. time in healthy Korean subjects following (A) single-dose desvenlafaxine and (B) multiple-dose desvenlafaxine (after 5 days of daily dosing). Data from one subject in the desvenlafaxine 200 mg group on day 1 (single-dose) was excluded due to vomiting which occurred within 2 h postdosing. Data from one subject in the desvenlafaxine 100 mg groups was excluded from the multiple dose analysis due to low or undetectable concentrations on days 7 and 8.

Pharmacokinetic parameters for plasma desvenlafaxine are summarized by dose group for single- and multiple-dose administration in Table 2. The mean t1/2 was consistent across doses with single- and multiple-dose administration. Single- and multiple-dose AUC24 and Cmax increased approximately proportionally with increasing desvenlafaxine dose. For single-dose desvenlafaxine, geometric mean Cmax increased 2.5-fold between the 50- and 100-mg dose groups and 1.8-fold between 100- and 200-mg doses; respective increases in AUC were 2.3- and 1.9-fold. For multiple-dose desvenlafaxine, geometric mean Cmax increased 2.4-fold from the 50 mg to the100 mg dose, and 1.8-fold from 100 mg to 200 mg; AUC24 increased 2.5- and 1.6-fold, respectively. For the 4-fold increase in dose from 50 mg to 200 mg desvenlafaxine, AUC for single-dose and AUC24 for multiple-dose administration increased 4.3- and 4.1-fold, respectively; Cmax values increased 4.5- and 4.3-fold for single-dose and multiple-dose, respectively. Figure 2 shows dose normalized Cmax and AUC24 in comparison to data from a US population for multiple-dose desvenlafaxine 50 mg [16]. Mean weight-normalized Cl/F was similar across the dose groups following single- and multiple-dose desvenlafaxine (Table 2). Accumulation of desvenlafaxine exposure (AUC24) at steady state was approximately 1.5- 1.7-fold compared with single-dose conditions and appeared to be independent of dose.

Parametera Single Desvenlafaxine Dose (Day 1) Multiple Desvenlafaxine Doses (Day 8)
50 mg (n=10) 100 mg (n=10) 200 mg (n=9) 50 mg (n=10) 100 mg (n=9) 200 mg (n=10)
AUC, ng•h/mL 2709 (29) 6244 (20) 11580 (8) ND ND ND
AUC24, ng•h/mL 1706 (28) 4119 (24) 7886 (15) 2845 (20) 7094 (9) 11620 (16)
Cmax, ng/mL 106.1 (28) 261.4 (28) 476.2 (25) 167.5 (17) 408.5 (11) 715.3 (16)
Tmax,h 4.0 (4.0–8.0) 5.0 (4.0–10.0) 6.0 (2.0–10.0) 4.0 (1.0–4.0) 4.0 (2.0–8.0) 4.0 (2.0–6.0)
t1/2, h 13.49 (21) 12.81 (33) 10.75 (16) 12.56 (19) 12.92 (19) 11.97 (18)
Cl/F/Wt, L/h/kg 0.298 (27) 0.253 (37) 0.271 (9) 0.284 (18) 0.227 (11) 0.271 (11)
Vz/F, L 352.5 (30) 282.0 (36) 265.0 (17) 314.0 (24) 259.2 (25) 292.5 (24)
Rac ND ND ND 1.663 (21) 1.669 (26) 1.478 (13)
Rac, Cmax ND ND ND 1.578 (17) 1.488 (22) 1.499 (30)

Table 2: Plasma desvenlafaxine pharmacokinetic parameters in healthy Korean subjects following single and multiple doses of desvenlafaxine.


Figure 2: Dose-normalized (A) Cmax and (B) AUC24 for plasma concentrations of desvenlafaxine after 5 days of daily dosing. Data from one subject in the desvenlafaxine 100 mg group was excluded due to low or undetectable plasma concentrations on days 7 and 8. *US data from Nichols et al. [16]. Cmax: Peak plasma concentration; AUC24: Area under the plasma concentration-time curve from time 0-24 h post-dose.


TEAEs were reported by 16 (52%) subjects in the desvenlafaxine groups (50 mg, 3/10; 100 mg, 7/11; 200 mg, 6/10) and 2 (33%) subjects in the placebo group. Nausea and headache were the only TEAEs reported by 2 or more subjects in any treatment group. Nausea was reported by 3/10, 6/11, and 4/10 subjects in the desvenlafaxine 50 mg, 100 mg, and 200 mg groups, respectively (placebo, 0), and headache was reported by 2/10, 0/11, and 1/10 subjects, respectively (placebo, 1/6). No subjects discontinued due to AEs or experienced serious or severe AEs during the study

Laboratory test results of potential clinical importance were observed in 16/31 subjects receiving desvenlafaxine and 3/6 subjects receiving placebo. None of those results were considered clinically significant. Vital sign measures of potential clinical importance were reported in 4 subjects receiving desvenlafaxine and 4 subjects receiving placebo, and ECG results of potential clinical importance were reported in 12 subjects receiving desvenlafaxine and 1 subject receiving placebo. None were considered clinically significant.


This study is the first to provide pharmacokinetic and safety data for oral desvenlafaxine in healthy Korean adults. Under both single and multiple-dose conditions, there was an approximately linear relationship between desvenlafaxine dose and exposure (AUC and Cmax) over the dose range of 50 mg to 200 mg. Dose normalized AUC, Cmax and CL/F values were similar across dose groups and showed no visible trend to increase or decrease with increasing desvenlafaxine dose. Multiple-dose pharmacokinetics was able to be adequately predicted from single-dose pharmacokinetics, with no unexpected accumulation of desvenlafaxine following daily doses of 50 mg, 100 mg, and 200 mg for 5 days.

Pharmacokinetic profiles for single- and multiple-dose desvenlafaxine in healthy Korean subjects were similar to those previously observed in healthy mixed (African American and Caucasian) US populations [15,16], and in Chinese [26] and Japanese [25] subjects. These results are not expected, given the simple metabolic pathway of desvenlafaxine, which is largely independent of the CYP isoenzyme pathways [11,24]. For the healthy adult Korean subjects receiving multiple-dose desvenlafaxine 50 mg in the current study, the geometric mean AUC24 was 2845 ng·h/mL and Cmax was 168 ng/mL, and median Tmax was 4.0 h after 5 days of daily dosing. Similar values were reported in a study in 28 US subjects (64% African American, 21% Caucasian) receiving desvenlafaxine 50 mg for 5 days (AUC24= 2853 ng·h/mL, and Cmax=174 ng/mL; median Tmax=4.0 h) [16]. Other studies of single- and multiple-dose administration in US and French subjects have demonstrated that desvenlafaxine Cmax and AUC increase in a linear, dose-proportional manner over the dose range of 150-900 mg/day [15].

There were no new safety findings in this study. No severe or serious AEs were reported, and no clinically important changes in clinical laboratory values, vital signs, or ECG recordings were observed. The most common TEAEs, nausea and headache, were reported in other pharmacokinetic studies of desvenlafaxine in healthy adults [15- 17,25,27] and in a pooled analysis of 9 studies of desvenlafaxine (50- 400 mg for 8 weeks) in patients with MDD [28].


In healthy Korean subjects administered desvenlafaxine 50 mg to 200 mg, multiple-dose pharmacokinetics was dose proportional and was predicted from single-dose pharmacokinetics. Pharmacokinetic parameters in this population were similar to values observed in non- Asian populations. There were no new safety findings for desvenlafaxine in this study.


This study was sponsored by Pfizer. Medical writing support was provided by Kathleen Dorries, PhD, and Lela Creutz, PhD, of Peloton Advantage and was funded by Pfizer.


YL and AP are employees of Pfizer Inc. RQ, WSL and AN are former employees of Pfizer Inc. SK and IJJ have nothing to disclose.


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