alexa Physical Exercise in Patients with Cancer Cachexia | OMICS International
ISSN: 2157-7595
Journal of Yoga & Physical Therapy

Like us on:

Make the best use of Scientific Research and information from our 700+ peer reviewed, Open Access Journals that operates with the help of 50,000+ Editorial Board Members and esteemed reviewers and 1000+ Scientific associations in Medical, Clinical, Pharmaceutical, Engineering, Technology and Management Fields.
Meet Inspiring Speakers and Experts at our 3000+ Global Conferenceseries Events with over 600+ Conferences, 1200+ Symposiums and 1200+ Workshops on
Medical, Pharma, Engineering, Science, Technology and Business

Physical Exercise in Patients with Cancer Cachexia

Shinichiro Morishita*

Institute for Human Movement and Medical Sciences, Niigata University of Health and Welfare, Niigata, Japan

*Corresponding Author:
Shinichiro Morishita
Institute for Human Movement and Medical Sciences
Niigata University of Health and Welfare
Niigata, Japan
Tel: +81-25-257-4300
Fax: +81-25-257-4300
E-mail: [email protected]

Received date: November 01, 2016; Accepted date: November 03, 2016; Published date: November 10, 2016

Citation: Morishita S (2016) Physical Exercise in Patients with Cancer Cachexia. J Yoga Phys Ther 6:e127. doi:10.4172/2157-7595.1000e127

Copyright: © 2016 Morishita S. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Visit for more related articles at Journal of Yoga & Physical Therapy



Cancer cachexia results from numerous complex factors, involving a decline in muscle mass and physical function that occurs with cachexia [1,2]. Thus, it is a combination of anorexia and wasting syndrome due to cachexia [3]. Cancer cachexia is a complex disorder characterized by progressive weight loss with catabolism of adipose tissue and skeletal muscle, affecting approximately 50%–80% of cancer patients, leading to substantial weight loss, primarily due to the loss of skeletal muscle and body fat [4,5]. Although cachexia is defined as the loss of muscle, fat may also be lost [6]. Cancer patients often experience muscle wasting and appetite loss as well as anorexia and fatigue. In addition, they find it difficult to perform regular daily activities [7,8]. This difficulty may also be due to cancer cachexia. These patients have a poor overall quality of life and shorter survival time [9,10]. There are different stages of cancer cachexia that are defined by differences in food intake, weight loss, and ability to function. Proposed three stages of cancer cachexia: pre-cachexia, cachexia, and refractory cachexia.


Pre-cachexia starts with the metabolic change with substantial involuntary weight loss (≤ 5%).


In this phase, patients have >5% loss of body weight or <20 kg/m2 loss of body mass index and an ongoing weight loss of >2%.

Refractory cachexia

In this phase, patients are not responsive to anticancer treatment. They are characterized by low performance status and have an expected survival time of less than 3 months.

Physical Exercise

Physical exercise can improve the fitness or health of patients with cancer cachexia [11]. Physical exercises have an important role in sustaining and building muscle mass; it is thus beneficial to people with cancer cachexia or those at risk of cancer cachexia. It is also effective in improving physical activity levels in cancer survivors [12]. A systematic review has identified benefits including improvement in physical activity levels, aerobic fitness, muscular strength, functional quality of life, anxiety and self-esteem in cancer survivors [13]. Aerobic and resistance exercises or a combination of both, have been found to improve upper and lower body strength compared with usual care [14]. Physical exercise helps maintain or slow the loss of physical function [15]. Aerobic exercise training for skeletal muscles improves wasting in both cardiac and cancer cachexia [16]. Physical exercise may promote a disruption in the cycle of events leading to cachexia advancement and in turn may promote enhanced functionality, thus improving the quality of life of cancer patients [17]. Physical exercise has been suggested to counteract the effect of exercise training in cancer cachexia [18]. Furthermore, physical exercise is associated with reduced levels of C-reactive protein in cancer patients [19]. It has been proposed as a complementary treatment in cancer patients and represents a function preserving, anti-inflammatory, and metabolism-modulating strategy that has a low cost [20]. It may reverse protein degradation, while increasing protein synthesis and lean body mass, thus counteracting the wasting seen in cachexia [21]. As described above, physical exercise may benefit patients with cancer cachexia. Research investigating physical activity/exercise in cancer patients undergoing treatment has demonstrated an improvement in physical performance, fatigue and functional quality of life. However, there is insufficient evidence to determine the effectiveness of physical exercise in cancer cachexia patients. Future studies on the effect of physical exercise on patients with cancer cachexia during each phase need to be conducted. Additionally, the intensity and duration of physical exercise can be changed to suit the needs of the patients in each stage; patients in pre-cachexia phase may be able to perform aggressive physical exercise; however, such exercises might not be suitable for patients in the refractory cachexia phase.


Select your language of interest to view the total content in your interested language
Post your comment

Share This Article

Recommended Conferences

Article Usage

  • Total views: 8950
  • [From(publication date):
    November-2016 - Jun 18, 2018]
  • Breakdown by view type
  • HTML page views : 8837
  • PDF downloads : 113

Post your comment

captcha   Reload  Can't read the image? click here to refresh

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

+1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals


[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

geneticsmolbio[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
Leave Your Message 24x7