alexa Plants as an Alternate System for the Large Scale Production of Recombinant Therapeutic Proteins | Open Access Journals
ISSN: 2161-1009
Biochemistry & Analytical Biochemistry
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Plants as an Alternate System for the Large Scale Production of Recombinant Therapeutic Proteins

Bala Murugan Shanmugaraj2 and Sathishkumar Ramalingam1,2*

1Plant Genetic Engineering Laboratory, Department of Biotechnology, Bharathiar University, Coimbatore, India

2BU-DRDO Centre for Life Sciences, Bharathiar University, Coimbatore, India

*Corresponding Author:
Ramalingam S K
Plant Genetic Engineering Laboratory
Department of Biotechnology
Bharathiar University, Coimbatore, India
Tel: +91-9360151669
Fax: +91-422-2422387
E-mail: [email protected]

Received Date: October 31, 2014; Accepted Date: November 03, 2014; Published Date: November 10, 2014

Citation: Shanmugaraj BM, Ramalingam SK (2014) Plants as an Alternate System for the Large Scale Production of Recombinant Therapeutic Proteins. Biochem Anal Biochem 3:i101. doi: 10.1472/2161-1009.1000i101

Copyright: © 2014 Ramalingam S K, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Due to the recent advancement in transient gene expression technologies in plants, a novel area called Plant Molecular Pharming has emerged. The major advantages includes cheaper, rapid, scalable and safer therapeutics are the reality, as there won’t be any natural human pathogen contamination in plant produced recombinant proteins. Researchers have expressed successfully even complex proteins e.g. fully assembled immunoglobulin in plants, which have been proved to be functionally active.

However, there are still challenges to overcome that includes, difference in post translational modification and difficulties in downstream processing as plants contain millions of metabolites. Once these issues are solved, plant molecular pharming industry will become a reality and will be a big boon for the developing countries in order to produce cheaper vaccine.


Figure 1: Overview of Transient Gene Expression in Plants for the Production of Therapeutic Proteins

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