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Prenatal Repair of Myelomeningocele | OMICS International
ISSN: 2329-6895
Journal of Neurological Disorders
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Prenatal Repair of Myelomeningocele

Jose Roberto Tude Melo*, Paulo Roberto Tavares Gomes Filho, Caio Nogueira Lessa, Kleber Pimentel Santos, Gilvan da Silva Figueiredo and Vera Lucia Fernandes de Azevedo
Group of Fetal Surgery, Maternity Climério de Oliveira - Federal University of Bahia, Brazil
Corresponding Author : Jose Roberto Tude Melo, MD, PhD
Pediatric Neurosurgery Hospital Martagão Gesteira (Children Hospital) Hospital Sao Rafael Federal
University of Bahia
Brazil Neurocirurgia Pediatricam RM 14147, Brazil
Tel: (00-55-71)21092611/99791806
E-mail: [email protected]
Received November 01, 2014; Accepted November 03, 2014; Published November 05, 2014
Citation: Melo JRT (2014) Prenatal Repair of Myelomeningocele. J Neurol Disord 2:i106. doi: 10.4172/2329-6895.1000i106
Copyright: © 2014 Melo JRT, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

The myelomeningocele (MMC) is a failure in embryo development during the fourth week of gestation, being the most common form of spinal dysraphism characterized by a protrusion of the meninges, roots and spinal cord by a bony midline defect [1,2]. The MMC treatment is surgical and should be implemented as soon as possible in order to reduce the exposure of the neural tissue and consequently the risk of infections and worsening of neurological deficits [3,4]. The incidence of hydrocephalus is higher in cases of neonates whose surgical repair of MMC is done after the child's birth (postnatal repair of myelomeningocele), when compared to the group of children undergoing intrauterine surgery [4]. For children whose correction and closing of the MMC is still done during intrauterine life (known as intrauterine fetal open surgery; (Figure 1), the incidence of hydrocephalus can be reduced by 50%, as well as motor deficits [4]. In Figure 1 we show the image of the first fetal neurosurgery performed in the northeast region of Brazil, with excellent result [5].

Description
The myelomeningocele (MMC) is a failure in embryo development during the fourth week of gestation, being the most common form of spinal dysraphism characterized by a protrusion of the meninges, roots and spinal cord by a bony midline defect [1,2]. The MMC treatment is surgical and should be implemented as soon as possible in order to reduce the exposure of the neural tissue and consequently the risk of infections and worsening of neurological deficits [3,4]. The incidence of hydrocephalus is higher in cases of neonates whose surgical repair of MMC is done after the child's birth (postnatal repair of myelomeningocele), when compared to the group of children undergoing intrauterine surgery [4]. For children whose correction and closing of the MMC is still done during intrauterine life (known as intrauterine fetal open surgery; (Figure 1), the incidence of hydrocephalus can be reduced by 50%, as well as motor deficits [4]. In Figure 1 we show the image of the first fetal neurosurgery performed in the northeast region of Brazil, with excellent result [5].
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