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Primary Central Nervous System Lymphoma or Multiple Sclerosis
ISSN: 2155-9562

Journal of Neurology & Neurophysiology
Open Access

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Primary Central Nervous System Lymphoma or Multiple Sclerosis

Min Chen1, Zhikang Zhao1 and Hongbo Liu2*
1Department of Neurology, First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, China
2Department of MRI, First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, China
*Corresponding Author: Hongbo Liu, Department of MRI, First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, China, Tel: 86-371-66862122, Fax: +86-371-66278077, Email: [email protected]

Received Date: Apr 12, 2018 / Accepted Date: Apr 28, 2018 / Published Date: Apr 30, 2018

Abstract

We reported a 52 years old female patient presented with sleep habit changing, slugishness and progressive legs weakness. Her brain MRI shows lesions in bilateral subcortex, bilateral periventricular region, left pedunculus cerebri, callosum, left thalamus, bilateral basal ganglia region, displaying longT1, long T2 signal, with some lesions enhanced after contrast administration. The pathology obtained from brain biopsy suggested diffuse large B-cell lymphoma.

Keywords: MRI; Lymphoma; Multiple sclerosis

Clinical Image

A 52 years old female patient changed her sleep habit- her sleep time increased gradually during the last 3 months. She became sluggish during the last 1 month. 4 days before she was admitted to our department, she developed progressive legs weakness. Her brain MRI shows lesions in bilateral subcortex, bilateral periventricular region, left pedunculus cerebri, callosum, left thalamus, bilateral basal ganglia region, dispalying long T1, long T2 signal, with some lesions enhanced after contrast administration (Figure 1). She was misdiagnosed as multiple sclerosis and given glucocorticoid through intravenous drip [1-5]. She recovered rapidly, but relapsed after 3 weeks. She underwent brain biopsy during the second admition. The pathology suggested diffuse large B-cell lymphoma. Then she was given chemotherapy, but unfortunately, she died half a year later.

Figure 1: (A) Bilateral subcortex lesions displayed high signal on T2 FLAIR. (B) Lesions in bilateral periventricular region displayed high signal on T2 FLAIR. (C) The lesion in the left pedunculus cerebri displayed high signal on T2 FLAIR. (D) The lesion in the left subcortex displayed homogeneous enhancement on T1-weighted contrast-enhanced MRI. (E) The lesion in the left periventricular region displayed ring-enhancement on T1-weighted contrastenhanced MRI. (F) The lesion in the left pedunculus cerebri displayed no enhancement on T1-weighted contrast-enhanced MRI.

References

Citation: Chen M, Zhao Z, Liu H (2018) Perspectives on recovery from coma and low arousal. J Neurol Neurophysiol 9: i109. DOI: 10.4172/2155-9562.1000i109

Copyright: © 2018 Chen M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.

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