alexa Primary Pulmonary Aspergillosis | OMICS International
ISSN: 2161-105X
Journal of Pulmonary & Respiratory Medicine

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Primary Pulmonary Aspergillosis

Jesus Molina Paris1*, Vicente Plaza2, Miguel Angel Lobo Alvarez3, Xavier Muñoz4, Manuel Pimentel Leal5 and Eduard Tarragona6

1Family and Community Medicine, Centro de Salud Francia, Fuenlabrada, Madrid, Spain

2Department of Respiratory Medicine, Hospital de la Santa Creu i Sant Pau, Institut d’Investigacio Biomedica Sant Pau (IIB Sant Pau), Department of Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain

3Family Medicine, GRAP, EAP Gandhi, Madrid, Spain

4Pneumology Service, Hospital Universitari Vall d’Hebron, Barcelona, Spain

5Family and Community Medicine, EAP Torito, IMSALU, Madrid, Spain

6Department of Medical, Chiesi, Barcelona, Spain

*Corresponding Author:
Jesus Molina Paris
Centro de Salud Francia, Calle de Francia
38, 28943 Fuenlabrada, Madrid, Spain
Tel: +34916084215
E-mail: [email protected]

Received date: September 15, 2015; Accepted date: December 29, 2015; Published date: December 31, 2015

Citation: Paris JM, Plaza V, Alvarez MAL, Munoz X, Leal MP, et al. (2015) Asthma Diagnosis in Spain: Survey of Opinions, Attitudes and Knowledge among Primary Care Physicians. J Pulm Respir Med 5: 308. doi:10.4172/2161-105X.1000308

Copyright: © 2015 Paris JM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Clinical Image


Elderly immunocomptetent female presented with cough and breathlessness of 3 weeks duration. Physical examination revealed absence of breath sound in both upper lobe areas. Sputum examination was negative for acid fast bacilli (AFB). Chest radiograpgh showed bilateral upper lobe homogenous opaqcity. Contrast enhanced CT (CECT) chest showed complete cut off of right upper lobe bronchus with collapse of both right and left upper lobe. Bilateral upper lobe collapse is uncommon and can be secondary to mucous plugging in ventilated patients. In our case it was due to gelatinous mucous blobs occluding both the upper lobe segmental openings (Figure 1). Bronchoscopy image showing gelatinous mucous blob occluding right upper lobe. These blobs could be dislodged during bronchoscopic suction and there was an associated mucosal inflammation. Golden gelatinous blobs are quite typical of mycotic infections in the airways. This was confirmed by the bronchial lavage cytology sample which was suggestive of aspergillus by special staining and morphology. Bronchoscopy was also therapeutic as gelatinous blobs could be sucked out and collapsed lobe expanded (Figure 2). Periodic acid Schiff (PAS) stain for fungus from bronchial lavage showed occasional fungal hyphae and Gomori Methenamine Silver (GMS) staining showed septate fungal hyphae with acute branching suggestive of Aspergillus sps (Figure 3). Chest X-ray on follow up after one month showed drastic resolution of lung lesions after the patient underwent bronchoscopic suction and was also given a course of anti -fungal agent mycamine which is an ecchinocandin for 2 weeks followed by oral itracanazole for 4 weeks. Both the upper lobe collapse had resolved and upper lobes were re-aerated (Figure 4).

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