alexa Profound Connection between Chronic Kidney Disease and Both Colorectal Cancer and Renal Cell Carcinoma | OMICS International
ISSN: 2472-1220
Journal of Kidney

Like us on:

Make the best use of Scientific Research and information from our 700+ peer reviewed, Open Access Journals that operates with the help of 50,000+ Editorial Board Members and esteemed reviewers and 1000+ Scientific associations in Medical, Clinical, Pharmaceutical, Engineering, Technology and Management Fields.
Meet Inspiring Speakers and Experts at our 3000+ Global Conferenceseries Events with over 600+ Conferences, 1200+ Symposiums and 1200+ Workshops on
Medical, Pharma, Engineering, Science, Technology and Business

Profound Connection between Chronic Kidney Disease and Both Colorectal Cancer and Renal Cell Carcinoma

Ito C* and Nagata D

Division of Nephrology, Department of Medicine, Jichi Medical University, Japan

*Corresponding Author:
Chiharu Ito
Division of Nephrology
Department of Medicine
Jichi Medical University
Yakushiji 3311-1
Shimotsuke, Tochigi, Japan 329-0498
Tel: +81-285-58-7346
Fax: +81-285-44-4869
E-mail: [email protected]

Received Date: December 19, 2015; Accepted Date: February 25, 2016; Published Date: February 29, 2016

Citation: Ito C, Nagata D (2016) Profound Connection between Chronic Kidney Disease and Both Colorectal Cancer and Renal Cell Carcinoma. J Kidney 2:118. doi:10.4172/2472-1220.1000118

Copyright: © 2016 Ito C, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Visit for more related articles at Journal of Kidney


Cancer risk in maintenance hemodialysis patients has been studied epidemiology, which might be influenced by various factors. On the contrary, investigation of cancer-bearing in non-dialysis chronic kidney disease patients has been rarely reported. Recently, we revealed relatively frequent past history of both colorectal cancer and renal cell carcinoma ahead of dialysis introduction and prevalence of colorectal cancer during the dialysis introduction period. In this article, we discuss the pathological relationship between chronic kidney disease and colorectal cancer and furthermore outline the susceptibility of chronic kidney disease after treatment of renal cell carcinoma.


Colorectal cancer; Renal cell carcinoma; Chronic kidney disease; Hypovitaminosis D; Vitamin D receptor polymorphisms; Methylenetetrahydrofolate reductase polymorphisms; Radical nephrectomy

Short Communication

The incidence of malignant tumors in non-dialysis chronic kidney disease (CKD) and end-stage renal disease (ESRD) patients compared with the general population remains under debate [1-3]. Excess tumor burden in these populations is inconclusive, in part because study designs are not prospective, adequate size case-cohort studies. Most research on dialysis patients is conducted on the methodological ground that patient identification and selection processes are simpler than for non-dialysis CKD patients, and that cancer screening is carried out routinely in almost all dialysis centers. At any rate, most of nephrologists or dialysis clinicians realize a fact that it is not rare to encounter cancer-bearing patients when dialysis introduction. Recent study also showed that the most common diagnostic period in which malignant tumors are identified in dialysis patients is after a few of years of dialysis introduction [4].

Vamvakas et al. reported that the potential mechanisms for malignant transformation in ESRD are impaired function of the immune system, reduced antioxidant defense, and accumulation of carcinogenic compounds [5]. Unfortunately, each potential factor has not been verified clinically in ESRD patients since publication of the authors’ research. As the mechanisms are either pleiotropic or other genetic or dialysis-related factors, such as exogenous viral infection, exposure to bisphenol A from the dialysis membrane [6] or the presence of diabetes mellitus [7], findings can be difficult to interpret. Individual tissue or organ tumorigenesis is thought to be affected by dialysis duration [8]. To reduce the possibility of these additional factors having an effect, it is desirable that the possible scope of tumorigenesis in CKD patients be limited to non-dialysis CKD or the introduction to dialysis period.

Recently, we reported the relatively-high incidence of colorectal carcinoma CRC before and during the dialysis introduction period [9]. A causal relationship between CKD and CRC have been assumed. Recent epidemiological and gene analysis data suggest that hypovitaminosis D or vitamin D receptor polymorphisms are associated with CRC [10,11]. The anti-tumoral actions of 1,25(OH)2D3 towards CRC are known to be inhibition of proliferation, pro-apoptotic effects, induction of differentiation, inhibition of angiogenesis, and detoxification [12]. Whereas CKD is a well-known cause of hypovitaminosis D [13], the latest meta-analysis negates an association between vitamin D receptor polymorphisms and the development of ESRD [14]. The significance of hypovitaminosis D and vitamin D receptor polymorphisms in CKD patients with CRC is not entirely determined. At this stage, hypovitaminosis D is a promising link between CRC and CKD (Figure 1).


Figure 1: Connection between chronic kidney disease and both colorectal cancer and renal cell carcinoma.

Folate and homocysteine metabolism abnormality is thought to be an independent risk factor for the development of CKD [15,16]; although, serum levels of folate and homocysteine in non-dialysis CKD or ESRD patients with CRC have not been clearly identified. Polymorphic associations in key folate-metabolizing genes, mainly methylenetetrahydrofolate reductase (MFHR), with susceptibility to CRC have been extensively studied. MFHR C677T polymorphism is a common genotype showing increased risk of CKD [17] and CRC [18] (Figure 1), and further studies examining commonality are expected.

Treatment-related kidney injuries with oxaliplatin [19] and cancer associated nephropathy are also suggested causes of CKD in CRC patients (Figure 1).

From our previous study, it appeared that a past history of renal cell carcinoma (RCC) was common to dialysis patients [9]. In this study, all patients who had RCC had received unilateral radical nephrectomy (RN). It is evident that patients undergoing RN have a high rate of new onset CKD [20], and that the presence of preoperative CKD is an independent risk factor for further progression of renal insufficiency after renal surgery [21] (Figure 1). A recent Taiwanese study reported that patients with RCC undergoing RN do not have a significantly higher risk of ESRD than those undergoing partial nephrectomy [22]. In that study, the median followup was 48 months, which is too short a time to draw any significant conclusions. Follow-up of residual renal function after RN may still be required to intervene before the development of ESRD.

From review and discussion of the above studies, it is suggested that the pathological conditions and treatments of CRC are linked with the development of CKD, and RN for RCC might lead to the development of ERSD. Further research is needed to determine any clinico-epidemiological linkage between these two carcinomas and non-dialysis-CKD or ESRD.


Select your language of interest to view the total content in your interested language
Post your comment

Share This Article

Relevant Topics

Recommended Conferences

  • International Conference on Medical and Health Science
    August 24-25, 2018 Tokyo, Japan
  • 11th International Conference on Clinical and Medical Case Reports
    October 22-23, 2018 Istanbul, Turkey

Article Usage

  • Total views: 9718
  • [From(publication date):
    March-2016 - Aug 17, 2018]
  • Breakdown by view type
  • HTML page views : 9601
  • PDF downloads : 117

Review summary

  1. Gabriella Simons
    Posted on Oct 21 2016 at 6:40 pm
    The topic discussed is highly relevant to clinicians. I would recommend a more focused discussion and not mixing up risk factors for CKD,ESRD and cancer for drawing clear cut conclusions.

Post your comment

captcha   Reload  Can't read the image? click here to refresh

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

+1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A


[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals


porn sex

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

Gaziantep Escort

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A


[email protected]

1-702-714-7001Extn: 9037


James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

mp3 indir

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals


Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T


[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version