alexa Prognosis of Orthostatic Hypotension | Open Access Journals
ISSN: 2155-9880
Journal of Clinical & Experimental Cardiology
Like us on:
Make the best use of Scientific Research and information from our 700+ peer reviewed, Open Access Journals that operates with the help of 50,000+ Editorial Board Members and esteemed reviewers and 1000+ Scientific associations in Medical, Clinical, Pharmaceutical, Engineering, Technology and Management Fields.
Meet Inspiring Speakers and Experts at our 3000+ Global Conferenceseries Events with over 600+ Conferences, 1200+ Symposiums and 1200+ Workshops on
Medical, Pharma, Engineering, Science, Technology and Business

Prognosis of Orthostatic Hypotension

Wilbert S Aronow*

Cardiology Division, Department of Medicine, New York Medical College, Valhalla, New York, USA

*Corresponding Author:
Wilbert S Aronow, MD, FACC, FAHA
Cardiology Division, New York Medical College, Macy Pavilion, Room 138
Valhalla, NY 10595, USA
Tel: (914) 493-5311
Fax: (914) 235-6274
E-mail: [email protected]

Received date: September 25, 2016; Accepted date: September 26, 2016; Published date: September 27, 2016

Citation: Aronow WS (2016) Prognosis of Orthostatic Hypotension. J Clin Exp Cardiolog 7:e147. doi:10.4172/2155-9880.1000e147

Copyright: © 2016 Aronow WS. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Visit for more related articles at Journal of Clinical & Experimental Cardiology

Editorial

Orthostatic hypotension is defined as a fall of 20 mm or more in systolic blood pressure or of 10 mm or more in diastolic blood pressure within 3 minutes of standing [1]. All persons receiving antihypertensive drugs routinely should have their blood pressure measured in the sitting position and within 3 minutes of standing [2]. Blood pressure should not be taken immediately after eating as postprandial hypotension may occur at that time [3]. Orthostatic hypotension and postprandial hypotension may coexist, and both disorders are associated with adverse clinical outcomes [3].

Orthostatic hypotension may be associated with advanced age, disorders associated with hypovolemia, hypertension, diabetes, neurological disorders, antihypertensive medications, antidepressants, antipsychotic drugs, anti-parkinsonian medications, alcohol, cardiovascular conditions, endocrine conditions, and other disorders [4]. The prevalence of orthostatic hypotension in older persons, mean age 82 years, in a long-term health care facility was 13% in 257 persons receiving cardiovascular or psychotropic drugs and 3% in those who did not receive cardiovascular or psychotropic drugs [1]. The prevalence of orthostatic hypotension in 4,733 diabetics, mean age 62.1 years, in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) blood pressure trial was 17.8% at baseline, 10.4% at 1 year, 12.8% at 4 years, and 20.0% at 1 or more visits [5]. The prevalence of orthostatic hypotension in 2,636 persons aged 75 years and older, mean age 79.9-years, in the Systolic Blood Pressure Intervention Trial (SPRINT) was 21.0% in persons randomized to a systolic blood pressure below 120 mmHg versus 21.8% in persons randomized to a systolic blood pressure below 140 mmHg [6]. The prevalence of orthostatic hypotension with dizziness was 1.9% in persons randomized to a systolic blood pressure below 120 mmHg versus 1.3% in persons randomized to a systolic blood pressure below 140 mmHg [6].

At 4-year follow-up of 3,522 older Japanese-American men in the Honolulu Heart program, orthostatic hypotension was significantly associated with increased all-cause mortality by 1.64 times [7]. At 4.4- year follow-up of 2,786 community dwelling older Italians, orthostatic hypotension was significantly associated with increased all-cause mortality by 1.23 times, with cardiovascular mortality by 1.41 times, and by non-cardiovascular mortality by 1.19 times [8]. At 22.7-year follow-up of 33,346 persons, mean age 45.7-years, in the Swedish Malmo Preventive Project, orthostatic hypotension was significantly associated with all-cause mortality by 1.21 times, with coronary events by 1.17 times, with stroke by 1.17 times, and by a composite endpoint of death, coronary event, or stroke by 1.18 times [9].

A meta-analysis included 13 prospective studies with 121,913 persons [10]. At 5-year follow-up of 65, 174 persons, orthostatic hypotension significantly increased all-cause mortality by 1.5 times. At 6.4-year follow-up of 49, 512 persons, orthostatic hypotension significantly increased coronary heart disease by 1.41 times. At 6.8 to 24-year follow-up of 50, 096 persons, orthostatic hypotension significantly increased heart failure by 2.25 times. At 6.8-year followup of 58, 300 persons, orthostatic hypotension significantly increased stroke by 1.64 times [10].

At 46.9-month follow-up in the ACCORD blood pressure trial, orthostatic hypotension was significantly associated with all-cause mortality by 1.61 times and with heart failure death or heart failure hospitalization by 1.85 times [5].

At 6-year follow-up of 12,433 black and white middle-aged men and women in the Atherosclerosis Risk in Communities study, orthostatic hypotension was significantly associated with coronary heart disease by 1.85 times [11]. At 7.9-year follow-up of 11,707 persons free of stroke and clinical heart disease at baseline in the Atherosclerosis Risk in Communities study, orthostatic hypotension was significantly associated with ischemic stroke by 2.0 times [12]. At 17.5-year followup of 12,363 persons free of heart failure at baseline in the Atherosclerosis Risk in Communities study, orthostatic hypotension was significantly associated with heart failure by 1.54 times [13]. At 13- year follow-up of 5,273 persons free of heart failure at baseline in the Cardiovascular Health Study, we reported that orthostatic hypotension was significantly associated with incident heart failure by 1.24 times [14]. Orthostatic hypotension may also cause syncope [4].

References

Select your language of interest to view the total content in your interested language
Post your comment

Share This Article

Relevant Topics

Article Usage

  • Total views: 8145
  • [From(publication date):
    September-2016 - Oct 23, 2017]
  • Breakdown by view type
  • HTML page views : 8062
  • PDF downloads :83
 

Post your comment

captcha   Reload  Can't read the image? click here to refresh

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords