alexa Proteins at Interfaces are Universal, but still Poorly Understood: A Challenge
ISSN: 2376-0214
Journal of Biodiversity, Bioprospecting and Development
Make the best use of Scientific Research and information from our 700+ peer reviewed, Open Access Journals that operates with the help of 50,000+ Editorial Board Members and esteemed reviewers and 1000+ Scientific associations in Medical, Clinical, Pharmaceutical, Engineering, Technology and Management Fields.
Meet Inspiring Speakers and Experts at our 3000+ Global Conferenceseries Events with over 600+ Conferences, 1200+ Symposiums and 1200+ Workshops on Medical, Pharma, Engineering, Science, Technology and Business
  • Editorial   
  • J Biodivers Biopros Dev 2015, Vol 2(2): e108
  • DOI: 10.4172/2376-0214.1000e108

Proteins at Interfaces are Universal, but still Poorly Understood: A Challenge

Robert E. Baier*
Department of Oral Diagnostic Sciences, State University of New York at Buffalo, USA
*Corresponding Author: Robert E. Baier, Distinguished Professor, Department of Oral Diagnostic Sciences, State University of New York at Buffalo, USA, Tel: 716 829-3560, Email: [email protected]

Received Date: Feb 16, 2015 / Accepted Date: Feb 17, 2015 / Published Date: Feb 19, 2015

Editorial

Volume 2, Issue 1 of Biodiversity, Bioprospecting and Development carried a very important article on Protein-Protein interactions (Hooi Ling Ho, Plant Protein Kinase and Protein-Protein Interaction, http://dx.doi.10.4172/2376-0214.1000142) that reminds us of the ubiquity of proteins throughout Nature’s domain. It is long overdue to resolve some fundamental issues of the appearance and organization of such important molecules that underlie all natural cellular attachments and biological interactions with increasingly diverse synthetics/prosthetics.

It is generally held that different specific proteins are adsorbed to inserted materials, when it is demonstrably more correct to report that –in any given biological phase—it is the same (usually not the most abundant) protein that deposits (entropically displacing water) at all material surfaces. Still in dispute, across diverse fields, is the architecture of such Nature-deposited critical films, as illustrated in the adjacent Diagram of possible Paths A & B to the same equilibrium thickness in the same time but with dramatically different consequences.

In Path A, long favored by many biologists, multi-layers of decreasingly denatured (flattened in the illustration shown) molecules deposit until a deposition vs re-entrainment equilibrium is reached; in Path B, today more conventionally cited, continuously deposited molecules force the earlier arrivals to become more erect and solution-phase-like until a true closely packed monolayer of essentially native molecules is present. Of enormous significance are the alternative predictions of each model, when it is realized that cell-surface interactions generally take place before the equilibrium states are obtained. In Path A, such interactions are with partially denatured molecules whose distortions can trigger similar anomalies in arriving cell behavior. In Path B, no such reactions to distorted protein molecules are anticipated, and explanations for differential cellular behavior are sought in (unlikely) different proteins being present or the consensus proteins deposited expressing only invariant native molecular aspects.

This may seem a bit like medieval “How many Angels can dance on the head of a pin?” philosophizing, but the implications for bioprospecting of new prosthetic implant materials or materials to be used in the sea— as just two of many examples—now prompt us to be more diligent in resolving the issues of proteins at interfaces: which are they?, have they displaced the boundary water?, are they denatured at the time of cellular arrival?, can we control those events by wiser material choices? Let us see your data, please! (Figure 1)

international-journal-biodiversity-Proteins-Interfaces

Figure 1: Proteins at Interfaces.

Citation: Baier RE (2015) Proteins at Interfaces are Universal, but still Poorly Understood: A Challenge . J Biodivers Biopros Dev 6: e108. Doi: 10.4172/2376-0214.1000e108

Copyright: ©2015 Baier RE. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Select your language of interest to view the total content in your interested language

Post Your Comment Citation
Share This Article
Recommended Conferences

9th World Conference on Earth Science

Beijing, China

2nd Global Summit on Earth Science and Climate Change

Prague, Czech Republic
Article Usage
  • Total views: 12511
  • [From(publication date): 3-2015 - Feb 23, 2020]
  • Breakdown by view type
  • HTML page views: 8712
  • PDF downloads: 3799
Share This Article
Top