Glocal Hospital, Krishnanagore, West Bengal, India
Received date: July 10, 2016; Accepted date: July 12, 2016; Published date: July 15, 2016
Citation: Bhattacharya SK, Ghoshal B (2016) Punched Out Lesions in the Skull in a Case of Multiple Myeloma. J Mol Imag Dynamic 6: i104. doi:10.4172/2155- 9937.1000i104
Copyright: © 2016 Bhattacharya SK, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Multiple myeloma; Electrophoresis; Skeletal system
A patient aged about 40 years presented with bony pain and mild fever. The patient was diagnosed to have multiple myeloma. Multiple myeloma is the most common primary malignant tumor of the skeletal system. It is a malignant proliferation of the plasma cells. This gives rise to monoclonal proliferation of these cells resulting in marrow infiltration and consequent increase of a single immunoglobulin and its fragments in the serum and urine. Plasma electrophoresis shows increased levels of immunoglobulins in the blood and light chains and Bence-Jones protein in the urine. Multiple destructive lytic lesions of the skeleton, and demineralization, as seen radiologically are characteristic of multiple myeloma (Figure 1).