alexa Radiation-Induced Esophageal Leiomyosarcoma 13 Years after Mediastinal Irradiation Following Surgical Removal of a Thymoma | Open Access Journals
ISSN: 2155-9619
Journal of Nuclear Medicine & Radiation Therapy
Like us on:
Make the best use of Scientific Research and information from our 700+ peer reviewed, Open Access Journals that operates with the help of 50,000+ Editorial Board Members and esteemed reviewers and 1000+ Scientific associations in Medical, Clinical, Pharmaceutical, Engineering, Technology and Management Fields.
Meet Inspiring Speakers and Experts at our 3000+ Global Conferenceseries Events with over 600+ Conferences, 1200+ Symposiums and 1200+ Workshops on
Medical, Pharma, Engineering, Science, Technology and Business

Radiation-Induced Esophageal Leiomyosarcoma 13 Years after Mediastinal Irradiation Following Surgical Removal of a Thymoma

Masaki Kunizaki1*, Shigekazu Hidaka1, Takuro Miyazaki1, Kazuo To1, Toru Yautake1, Atsushi Nanashima1, Terumitsu Sawai1, Hajime Isomoto2 and Takeshi Nagayasu1`

1Department of Surgical Oncology, Nagasaki University Hospital, Sakamoto, Nagasaki 852-8501, Japan

2Department of Gastroenterology and Hepatology, Nagasaki University Hospital, Sakamoto, Nagasaki 852-8501, Japan

*Corresponding Author:
Masaki Kunizaki
Division of Surgical Oncology
Department of Translational Medical Sciences
Nagasaki University Graduate School of Biomedical Sciences
1-7-1 Sakamoto, Nagasaki 852-8501, Japan
Tel: +95-819-7304
Fax: +95-819-7306
E-mail: [email protected]

Received date : March 26, 2015; Accepted date : April 23, 2015; Published date : April 27, 2015

Citation: Kunizaki M, Hidaka S, Miyazaki T, To K, Yautake T, et al. (2015) Radiation-Induced Esophageal Leiomyosarcoma 13 Years after Mediastinal Irradiation Following Surgical Removal of a Thymoma. J Nucl Med Radiat Ther 6:224. doi:10.4172/2155-9619.1000224

Copyright: © 2015 Kunizaki M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Visit for more related articles at Journal of Nuclear Medicine & Radiation Therapy

Abstract

Radiation-induced leiomyosarcoma is a very rare complication following irradiation of primary malignancies. In the chest wall, it is usually secondary to radiotherapy for breast cancer or lymphoma. Esophageal malignancy is a radiation dose-related complication of radiotherapy for breast cancer, but its absolute risk is low. A 61-year-old woman presented with an esophageal leiomyosarcoma 13 years after surgery plus mediastinal irradiation (55 Gy) for a stage III thymoma. Esophageal sarcoma is an uncommon tumor, reported sporadically in the literature. Radiotherapy is frequently used in the treatment of carcinoma of the esophagus, and the increased risk of development of sarcoma arising in irradiated fields is well known. The increasing use of radiotherapy for thymoma suggests that radiation-associated malignancies of the esophagus may be seen more frequently in the future. To the best of our knowledge, this is the first report of radiation-induced esophageal leiomyosarcoma after mediastinal irradiation of a thymoma.

Keywords

Radiation-induced leiomyosarcoma; Esophageal tumor; Thymoma

Introduction

Radiation-induced sarcoma (RIS) is a rare late complication after irradiation, with a reported incidence of 0.03%-0.8% [1]. In the chest wall, RIS most commonly follows radiotherapy for breast cancer or malignant lymphoma, appears rare following thymoma. Esophageal leiomyosarcoma is a rare malignant tumor, accounting for less than 1% of all malignant esophageal tumors [2-4]. 

Esophageal leiomyosarcoma typically occurs in the middle to distal third of the esophagus because the muscularis propria in that area consists of smooth muscle [5]. These lesions are generally small and asymptomatic, but occasionally can be large and produce dysphagia. Herein, we describe a case of radiation-induced esophageal leiomyosarcoma 13 years after irradiation of a thymoma. To the best of our knowledge, this represents the first such case to be reported.

Case Report

A 61-year-old woman was referred to hospital with pain and swallowing difficulty. She had undergone surgery for thymoma, which was completely resected together with the adjacent thymus and pericardium at 48 years of age. Adjuvant mediastinal irradiation to the primary site of the tumor using the opposing portal method at a dose of 45 Gy (1.8 Gy x 25) and a further 10 Gy (2 Gy x 5) was administered. Thus, the upper esophagus might have been exposed to a radiation dose of 55 Gy during the overall treatment for thymoma (Figure 1).

nuclear-medicine-radiation-Adjuvant-mediastinal

Figure 1: Adjuvant mediastinal irradiation to thethymus using the opposing portal method at a dose of 45 Gy (1.8 Gy per fraction) and a further 10 Gy (5 fractions at 2 Gy per fraction) was administered to the upper mediatinal field.

Esophagogastroduodenoscopy showed a stalked intraluminal polypoid mass in the upper thoracic esophagus (Figure 2). The tumor was large enough to fill the esophageal lumen, but allowed passage of a gastrofiberscope (Q260, Olympus, Tokyo, Japan) to the distal part of the esophagus. The specimens taken by endoscopic biopsy were histologically proven to be poorly-differentiated carcinomaand carcinosarcoma was suspected. Computed tomography showed a large, well-enhanced soft tissue mass in the upper esophagus with tracheal destruction (Figure 3), but no regional lymph node enlargement or liver metastases. Positron emission tomography (PET) - computed tomography (CT) showed intense segmental uptake of 18F-fluorodeoxyglucose (FDG) in the upper thoracic esophagus (Figure 4). Accordingly, the patient was diagnosed with esophageal carcinosarcoma (cT3(AD) N0M0 cStage II). The patient underwent transthoracic esophagectomy with three-field lymph node dissection and gastric tube reconstruction. Macroscopically, the resected specimen was a polypoid tumor measuring 6.5×2.7 cm (Figure 5). Histopathologically, the tumor comprised pleomorphic spindle cells with mitosis and cell necrosis, compatible with leiomyosarcoma. The tumor demonstrated a fascicular growth pattern with spindle-shaped cells demonstrating nuclear atypia and eosinophilic cytoplasm. Mitoses were also frequent, suggesting malignant proliferation (MIB1 >50%). Again, tumor cells stained positively for vimentin and smooth muscle actin (SMA), but negatively for desmin, S-100, CK7, CK20, c-Kit, and CD34 (Figure 6). Tumor invasion involved the mucosa. Regional lymph nodes were free of metastases. These final findings were consistent with the rare diagnosis of esophageal leiomyosarcoma. No adjuvant radiotherapy or chemotherapy was administered.The patient was discharged home on postoperative day 50 and is currently doing well as of 15 months after surgery.

nuclear-medicine-radiation-upper-esophagus

Figure 2: Esophagogastroduodenoscopy shows a large protruding region in the upper esophagus, 25-34 cm from the incisors.

nuclear-medicine-radiation-thoracic-esophagus

Figure 3: Computed tomography shows a large tumor in the upper thoracic esophagus with tracheal destruction.

nuclear-medicine-radiation-Positron-emission

Figure 4: Positron emission tomography-computed tomography shows intense segmental fluorodeoxyglucose uptake at the upper thoracic esophagus.

nuclear-medicine-radiation-macroscopic-findings

Figure 5: Macroscopic findings of the resected specimen show marked erosion. The resected specimen showed that the mass arising from the submucosa has grown into the lumen and measures about 6.5x2.7 cm. Figure

nuclear-medicine-radiation-resected-specimen

Figure 6: Histological findings of the resected specimen show a spindle cell tumor with cellular polymorphism, mimicking a storiform growth pattern (a). Hematoxylin and eosin staining (b, x 40). Immunohistochemistry shows positive staining for vimentin and α smooth muscle actin in the cytoplasm of the leiomyosarcoma (c,d, x 40)

Discussion

Mesenchymal tumors of the gastrointestinal tract are uncommon. They are usually found in the stomach and small intestine, but can originate throughout the length of the gastrointestinal tract. Those originating from the esophagus are unusual. The most common mesenchymal tumors are the gastrointestinal stromal tumors. These possess smooth muscle features on light microscopy, but in fact originate from interstitial cells derived from mesenchymal stem cells. Finding tumors that actually originate directly from smooth muscle is particularly rare, especially in the esophagus. Such tumors are termed leiomyomas or leiomyosarcomas. Leiomyosarcoma of the esophagus is a rare malignancy, accounting for less than 1% of all esophageal malignancies [2-4].

Leiomyosarcomas are most commonly located in the middle and lower thoracic esophagus because smooth muscle predominates in that area [5]. Esophageal leiomyosarcomas are typically divided into two types: the polypoid type, representing 60% of cases; and infiltrative type in 40% [6,7]. Traditionally, esophagectomy has been considered as the optimal standard management for the disease. However, in a few reports, local excision of some polypoid tumors achieving long-term survival [8]. The prognosis of esophageal leiomyosarcoma is better than that of esophageal squamous cell carcinoma because of its characteristics of slow growth and late metastases [9,10]. Patients with polypoid and intramural tumors, tumors in an intrathoracic location, and well-differentiated tumors display better prognoses than patients with infiltrating lesions, tumors in cervical locations, or poorly differentiated tumors [11,12]. The present case is unique, because the tumor showed good prognostic factors, such as polypoid type and intrathoracic location, but grew very rapidly and may occurred after radiotherapy. Mediastinal irradiation is known to be a causative factor in esophageal malignancies, but due to the small numbers reported in the literature, no definitive associations between mediastinal radiotherapy and leiomyosarcomas of the esophagus have been made. This represents the first documented case of leiomyosarcoma developing within the esophagus following mediastinal irradiation for thymoma. Many cases of radiation-induced sarcoma have been reported. Although evidence of an association between radiotherapy and leiomyosarcoma remains in sufficients, these cases highlight the possibility of an association, and thus reinforce the importance of maintaining clinical suspicion in post-radiotherapy patients presenting with similar symptoms. The following diagnostic criteria for RIS have therefore been proposed: development in the irradiated field; histological features of RIS differing from the original lesion; and a sufficiently long latent period between radiation and development of neoplasms of over 10 years [13]. The risk of RIS appears to be dose-related, with most cases occurring after receiving doses of at least approximately 55 Gy. The latency period between radiation exposure and development of sarcoma varies from 1.4 to 55 years, with most cases identified between 7 and 14 years [14]. The latency in our case was 13 years, and the radiation dose was 55 Gy. The present patient fulfilled the preceding criteria.

Thymoma is considered radiation-sensitive, and radiotherapy is often used for local control of the tumor. Mediastinal irradiation has been used not only for patients with unresectable tumors, but also as adjuvant therapy for those with Masaoka clinical stage III disease. However, the therapeutic value of adjuvant radiotherapy after complete resection of the tumor has still not been definitively established. Nonetheless, the 10-year survival reportedly exceeds 80% if stage III thymomas can be completely resected [15]. Furthermore, immunodeficiency can occur both in patients undergoing radiation therapy, as well as in patients who have had thymectomies [16]. Because many patients achieve long-term survival, even with advanced-stage thymomas, irradiation carries a long-term risks of RIS and immunodeficiency, and such patients therefore need long-term surveillance.

In conclusion, we have described an extremely rare case of radiation-induced esophageal leiomyosarcoma after irradiation of a thymoma. A significant increase has been noted in the number of long-term cancer survivors, in part thanks to recent advances in radiotherapy. Careful long-term surveillance is thus needed for patients treated with radiotherapy. In the current studies have shown that the 3D image-guided radiation therapy technique can effectively detect setup errors of patients undergoing RT, thereby reducing planning target volume margins. These advances will further reduce the radiation dose to critical organs and may reduce the risk of RIS [17]. In addition, effective treatment strategies for esophageal leiomyosarcoma occurring after irradiation need to be developed.

Conflict of interest

None of the authors have any conflicts of interest to disclose.

References

Select your language of interest to view the total content in your interested language
Post your comment

Share This Article

Recommended Conferences

Article Usage

  • Total views: 11639
  • [From(publication date):
    May-2015 - Oct 18, 2017]
  • Breakdown by view type
  • HTML page views : 7878
  • PDF downloads :3761
 

Post your comment

captcha   Reload  Can't read the image? click here to refresh

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords