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Relationship between Clinical and Histopathologic Findings of 40 Periapical Lesions

Francisco Javier Jimenez Enriquez*, Jorge Paredes Vieyra and Fabian Paredes Ocampo

Department of Oral Surgery, Autonomous University of Baja California, 710E San Ysidro Blvd 1513, San Ysidro, California-92173, USA

*Corresponding Author:
Francisco Javier Jimenez Enriquez
Department of Oral Surgery
Autonomous University of Baja California
710E San Ysidro Blvd 1513, San Ysidro
California-92173, USA
Tel: 011526646855665
Fax: 6105913231
E-mail: [email protected]

Received date: December 17, 2014; Accepted date: January 07, 2015; Published date: January 13, 2015

Citation: Enriquez FJJ, Vieyra JP, Ocampo FP (2015) Relationship between Clinical and Histopathologic Findings of 40 Periapical Lesions. Dentistry 5:277. doi: 10.4172/2161-1122.1000277

Copyright: © 2015 Enriquez FJJ, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Purpose: To relate the clinical and histopathological findings of periapical inflammatory lesions treated by endodontic surgery with the results of histopathological investigation of the same lesions.

Materials and methods: Forty biopsies obtained during periapical surgery were histologically analyzed following curettage of the tissue, establishing the diagnosis as either periapical granuloma, radicular cyst, or abscess. The radiographic size of the lesion (area in cm2) before surgery and after 2 years of follow-up was measured. The evolution at 48 months after surgery was evaluated according to the criteria of von Arx and Kurt. A statistical study was made, the inter-variable relationships were studied using analysis of variance with subsequent Tukey testing and calculation of Pearson?s correlation coefficient. The hypothesis tests were conducted at the 0.05 level of significance.

Results: Results indicated that 26 (65%) were women and 14 (35%) men at a mean age of 43.54 years (range,18 to 69 years) with 40 biopsy samples. 65.5% of lesions were granulomas, 20% cysts, and 17.5% abscess. The results showed that tooth lower second molar had a high percentage of periapical lesion corresponding to periapical granuloma associated with overfilled canals.

Conclusions: The outcomes of the present study show a high number of periapical granulomas among periapical cysts and confirms that periapical granulomas are the most common periapical lesions of endodontic origin associated with persistent apical periodontitis.


Apical periodontitis; Apical lesions; Granuloma; Cyst; Abscess


The goal of endodontic treatment is to prevent or cure apical periodontitis (AP) caused by infection of the root canal systems of the affected teeth [1] or due to persistence of the primary infection or emergence of infection after treatment [2].

When bacteria colonize only in the apical ramifications of the root canal or outside the root canal or when pathosis is sustained by a periapical foreign body the surgical procedure effectively removes the infected site and enhances the chances of healing [3].

Apical ramifications, lateral canals, and isthmuses connecting main root canals have all been shown to harbor bacterial cells, which are also frequently organized in biofilm-like structures [4-6]. In their natural habitats, microorganisms almost invariably live as members of metabolically integrated communities commonly attached to surfaces to form biofilms [7]. The biofilm provides microorganisms with a series of advantages and skills including establishment of a broader habitat range for growth; increased metabolic diversity and efficiency; protection against competing microorganisms, host defenses, antimicrobial agents, and environmental stress; and enhanced pathogenicity [8].

In situ investigations [9-12] using optical and/or electron microscopy have allowed observations of bacteria colonizing the root canal system in primary or persistent/secondary infections as sessile biofilms covering the dentinal walls.

Poor endodontic treatment allows canal reinfection, which may often lead to treatment failure [13]. Clinical signs and symptoms as well as radiographic evidence of periradicular lesions are usually associated with endodontic failure. When root canal therapy is performed according to accepted clinical principles and under aseptic conditions, the success rate is generally high.

Frequent indications for endodontic surgery have been suggested though contemporary practice proposes that endodontic surgery should be achieved only if conventional endodontic re-treatment will not remove potential areas of canal infection such as in an uninstrumented portion of a canal or will have the potential to irreversibly injury the tooth for example root fracture following to post removal, or if previous re-treatment has not resulted in healing [14].

Apical periodontitis is one of the most common pathological conditions within alveolar bone. Apical periodontitis consists of an inflammation and destruction of the tissues around the root of the teeth caused by etiological agents of endodontic origin [14,15].

It is usually a sequel of an endodontic infection that turns the dental pulp into a necrotic tissue infected by autogenous oral bacteria. This infection usually occurs through dental hard tissue damage resulting from caries, clinical procedures, or trauma and it provokes an inflammatory process that stimulates the proliferation of the cell rests of Malassez in the periodontal ligament [15].

The development of apical periodontitis can occur due to different mechanisms, such as accumulation of osmotic fluid in the lumen, proliferation of epithelial cell rests of Malassez, or molecular mechanisms [16].

As a result, clinicians often make clinical and radiographic diagnoses, and the removed periapical tissues are seldom submitted for histopathological analysis [17].

Clinical and radiological evaluations alone cannot properly identify the type of lesion in the apical area [18,19].

Many factors are involved in the healing process of a periapical defect following endodontic surgery [20]. Amongst these, the 2 layers of the periosteum are very important because they may act both as a source of osteo-competent cells and as a barrier against the infiltration of epithelial cells into the healing site. However, in large defects the periosteum is often damaged by the infective process [21].

Most persistent lesions remain asymptomatic [22-24], Friedman’s study [25] introduce the concept of asymptomatic function. In addition to the groups ‘‘healed,’’ ‘‘healing,’’ and ‘‘non-healed,’’ the American Association of Endodontists has added the group ‘‘functional’’ to endodontic treatment outcomes [26]. The concept of asymptomatic function or functional as a defined treatment outcome has implications for retreatment decision-making. The assumption that all persistent radiographic lesions represent persistent inflammatory lesions [27,28].

Matsumato et al. [29] showed that the prognosis for the surgical treatment of large periapical lesions was not as good as that of small lesions. Some authors [30] consider the size of the periapical lesion as a preoperative prognostic factor.

There has been a prolonged debate about the management of large periapical lesions, with some authors suggesting that they can only be treated successfully by surgical means and others proposing that they will heal after nonsurgical root canal treatment [31]. Periapical surgery attempts to contain any microorganisms within the canal by sealing the canal apically (at the same time the periapical lesion, if present, can be curetted and histologically investigated). The objective of this surgical procedure is to optimize the conditions for periapical tissue healing and regeneration of the attachment apparatus.

There are a number of classifications for periapical lesions of endodontic origin based on etiology, symptoms or histopathological features, for example The World Health Organization Classification leans toward a clinical classification [32].

Studies show that a periapical granuloma is the most common periapical lesion of endodontic origin, the diagnosis is based on the presence of connective tissue, blood vessels and inflammatory cells and may also be called chronic apical periodontitis when chronic inflammatory cells feature or secondary acute apical periodontitis when polymorphonuclear leukocytes are present [33].

The purpose of the present study was to relate the clinical and histopathological findings of periapical inflammatory lesions treated by endodontic surgery with the results of histopathological investigation of the same lesions.

We hypothesized that the results of histopathological findings related with clinical diagnostic of periapical inflammatory lesions are caused by periapical Granulomas.

Materials and Methods

This study design was an evaluation of a consecutive clinical sample of patients with persistent periapical pathosis who were seen by an endodontist at the University Autonomous of Baja California, School of Dentistry, Tijuana, Mexico. The subjects review committee approved the study and all the participants were treated in accordance with the Helsinki Declaration


A clinical follow-up study was carried out between Jan 2007 to June 2010. Forty patients with chronic periapical lesions were treated with endodontic Surgery after informed consent of each patient had been obtained after explaining the clinical procedures and risks involved and clarifying all questions raised by the patients.

Periapical pathosis was defined as a radiolucent lesion related with a root filled tooth with either (a) an extending periapical lesion as seen on a radiograph, (b) an unhealed periapical lesion of 5 or more years duration post-endodontic treatment [34], or (c) a tooth with a periapical radiolucent lesion with clinical signs and symptoms of periapical pathosis of endodontic origin such as pain, swelling, or sinus tract.

Data were collected using a protocol for each patient and stored in an automated database. The data were coded for later statistical processing.

The inclusion criteria for treatment planning for endodontic surgery were:

- Periapical disease affecting permanent teeth subjected to endodontic treatment, with the presence of pain or inflammation, and repeated failure of root canal treatment.

- Periapical disease causing pain or swelling and involving permanent teeth subjected to endodontic treatment with bridge abutments or teeth with posts presenting extraction difficulties.

- Where retreatment is impossible owing to fractured instruments, ledges, blockages, and filling material impossible to remove.

- An evaluation that any root canal obstacles could not be bypassed or removed to allow full conventional instrumentation of the root canal system.

a) With failure of orthograde retreatment where the prognosis of non-surgical retreatment is unfavorable or impractical (such as an extensive coronal restoration).

b) Where biopsy is needed.

c) Symptomatic gutta-percha over-filling or foreign bodies impossible to remove over an orthograde approach, radiolucencies larger than 8 to 10 mm in diameter.

Exclusion criteria were patients not meeting inclusion criteria or failure to obtain patient´s authorization. The material for this study consisted of sequential biopsies of roots or root tips together with adhering surrounding apical tissue. Specimens were part of the histologic collection of one of the authors. The material comprised 40 roots from 40 human teeth. Endodontic surgery was not carried out in the acute phase or during exacerbation of a chronic periapical abscess.

Surgical technique

All surgical procedures were carried out by an experienced Oral Surgeon; Endodontic surgery was carried out under local anaesthesia, Surgical approach was gained using a complete or partial Newman flaps and sufficient bone was removed using surgical burs with irrigation to allow curettage of the periapical lesion.

The periapical lesion was eliminated and placed in formalin (10%). Osteotomy was carried out using round 0.27 mm tungsten-carbide drills (Jota, Switzerland) mounted in a handpiece, and abundant irrigation with sterile physiological saline. The minimum apical resection necessary to access the apex was made, with subsequent apical curettage. The cavity for root-end filling was prepared with ultrasound, Piezon MasterR (EMS, Electro Medical Systems, Switzerland) and nondiamond ultrasound tips adapted to the different root and anatomic variants.

All other necessary clinical procedures were performed, such as root-end resection and root-end filling, and the flap sutured. Patients were given standard postoperative instructions and review appointments.

Magnifying glasses of 2.6 magnification OrascopticR (Acuity™ System. Kerr Corporation, Middleton, USA) were used to facilitate the procedure. Filling material was introduced and condensed (Super- EBA, 3M Dental Products, St Paul, MN) within the retrograde cavity, in all cases.

Tissue processing

All biopsies were taken during the endodontic surgery and immediately fixed in 10% formaldehyde solution with a surgical specimen/fixator volume ratio of 1:10. Samples were embedded in paraffin using an automated tissue processor (Autotechnicon Processor; Bayer Healthcare, LLC, Tarrytown, NY) and then prepared for histopathological diagnosis.

Microtome serial sections (6 to 8 microns) were later made with a Minot rotation microtome (Minotome; IEC, Needham Heights, MA). Sections were deparaffinized and systematically stained with hematoxylin eosin and a cover slip placed.

The histologic sections were examined under a Bx45 microscope (Olympus, Nishi-Shinjuku, Shinjuku-ku, Tokyo) by 2 experienced Oral Pathologists and a histopathological diagnosis was made as a result by consensus.

The specimens were classified, according to agreed criteria [35] as radicular cyst, scar tissue, or granuloma; it was also highlighted if the granuloma was a mixed form (being classified as epithelized granuloma or granuloma with fibrous tissue).

A diagnosis of periapical granuloma was made based on the histological findings of granulation tissue with inflammatory cells, no distinction was made between the presence of chronic inflammatory cells (chronic apical periodontitis) or acute inflammatory cells (secondary acute periodontitis); a cyst was identified when epithelium was seen to line a lumen, no distinction was made between a true cyst or bay (pocket) cyst; a scar was defined as dense relatively acellular fibrous connective tissue; and an abscess was defined as a collection of pus (dead and dying neutrophils).

Radiographic study

Periapical radiographs were taken before surgery and after 2 years. The images obtained were calibrated (Clini View Version 5.1 program Instrumentarium Imaging, Tuusula, Finland) before being analyzed using the MicroImage Pro-Plus Image analyzing system, (Media Cybernetics, Inc, Silver Spring, MD), measuring the area (cm2) of the lesion.

Prognostic assessment healing classification: The following criteria were used to evaluate the success of the periapical surgery. The clinical criteria of Mikkonen et al. [36] considering: a) success: when there is no pain, swelling or fistula, b) uncertain healing: radiographic evidence of bone destruction and presence or not of symptomatology; and c) failure: when there is bone destruction, root resorption and symptomatology.

The radiographic criteria of Rud et al. [37]:

i) Complete healing: complete bone regeneration, normal or slight increase in width of periodontal periapical space, but less than double the width of the unaffected radicular areas.

ii) Incomplete healing: reduced radiolucency, characterized by signs of bone healing around the periphery of the rarefaction.

iii) Doubtful healing: reduced radiolucency with one or more of the following characteristics: the radiolucency was greater than twice the width of the periodontal space, it was bordered by a structure such as hard lamina, it had a circular or semi-circular periphery, or was located symmetrically‘cone-like’ around the apex as an extension of the periodontal space.

iv) Radiographic failure: there were no changes, or there was an increase in radiolucency.

The clinical and radiographical criteria of Von Arx and Kurt [38] to determine overall evolution: a) success: when bone regeneration was ≥ 90% and the pain and clinical scales were 0 (on a scale of 0 to 3); b) improvement: when bone regeneration was between 50% and 90% and the pain and clinical scales were 0; and c) failure: when bone regeneration was less than 50% or there were clinical symptoms.

Finally, it was evaluated if the tooth was functional (remained in place) or not [39].

Statistical analysis

The data were coded for later statistical processing using the SPSS version 20 for Windows. Descriptive statistics were calculated for the relevant variables; specifically means, maximum and minimum relationships were studied using analysis of variance (ANOVA) with subsequent Tukey testing and calculation of Pearson’s correlation coefficient. The hypothesis tests were conducted at the 0.05 level of significance.


The study comprised 40 patients 26 women (65%) and 14 men (35%) at a mean age of 43.54 years (range, 18 to 69 years) with 40 biopsy samples (Table 1).

Endodonticlesions n (%)
Granuloma 25 (62.5%)
Cyst 8 (20%)
Abscess 7 (17.5%)
Total 40 (100%)

Table 1: Distribution of the periapical lesions.

The outcomes demonstrated that 40 cases were sent to the Laboratory of Oral Pathology, Facultad de Odontología Tijuana, with a clinical diagnosis of periapical inflammatory lesions. A possible diagnosis of periapical granuloma was hypothesized, after the histopathological analysis (Table 1), all cases were diagnosed as: Granuloma (62.5%), Cyst (20%) and Abscess (17.5%).

Our results showed that tooth 7 had a high percentage of periapical lesion corresponding to periapical granuloma associated with overfilled canals (Table 2).

Tooth Overfill n (%) Fractured Instrument   n(%) Short n (%) Total n (%)
8 3 (100.0%) 0 (0.0%) 0 (0.0%) 3 (100.0%)
7 5 (12.5%) 1 (2.5%) 1 (2.5%) 7 (100.0%)
6 0 (0.0%) 0 (0.0%) 1 (10.0 %) 1 (100.0%)
5 0 (0.0%) 0 (0.0%) 1 (10.0%) 1(100.0%)
4 1 (2.5%) 3 (7.5%) 1 (2.5%) 5 (100.0%)
3 0 (0.0%) 0 (0.0%) 1(10.0%) 1 (100.0%)
9 3 (7.5%) 1 (2.5%) 0 (0.0%) 4 (100.0%)
10 1 (2.50%) 1 (2.5%) 1 (2.5%) 3 (100.0%)
11 1 (100.0%) 0 (0.0%) 0 (0.0%) 1 (100.0%)
12 1 (5.0%) 0 (0.0%) 1 (5.0%) 2 (100.0%)
13 2 (5.0%) 0 (0.0%) 1 (2.5%) 3 (100.0%)
14 2 (5.0%) 0 (0.0%) 1 (2.5%) 3 (100.0%)
24 0 (0.0%) 0 (0.0%) 2 (10.0%) 2 (100.0%)
23 0 (0%) 1 (10.0%) 0 (0.0%) 1 (100.0%)
19 1 (10.0%) 0 (0.0%) 0 (0.0%) 1 (100.0%)
18 1 (10.0%) 0 (0.0%) 0 (0.0%) 1 (100.0%)
31 1 (10.0%) 0 (0.0%) 0 (0.0%) 1 (100.0%)
Total 22 (55%) 7 (17.5%) 11 (27.5%) 40 (100.0%)

Table 2: Relation between tooth and root canal treated.

The distribution of periapical lesions by age (Table 3) were high in patients with 40-50 years old with diagnostic of granuloma (66.6%).

According with the lesion’s size and patient’s age (Tables 3 and 4) were identified as periapical Granulomas in the group of 40-50 years of age (66.6%) with a size of >1.0 - <2 cm (37.5%).

Age Granuloma Cyst Abscess Total
n (%) n (%) n (%) n (%)
18-28 years 3 (60.0%) 1 (20.0%) 1 (20.0%) 5 (100.0%)
29-39 years 7 (63.6%) 4 (36.3%) 0 (0.0%) 11 (100.0%)
40-50 years 10 (66.6%) 2 (13.3%) 3 (20.0%) 15 (100.0%)
51-61 years 2 (40.0%) 1 (20.0%) 2 (40.0%) 5 (100.0%)
62-72 years 3 (75.0%) 0 (0.0%) 1 (25.0%) 4 (100.0%)
Total 25 (62.5%) 8 (20%) 7 (17.5%) 40 (100.0%)

Table 3: Distribution of Periapical lesions by group of age.

Age 0.5 cm >0. 5 - <1 cm >1.0 - <2 cm Total
n (%) n (%) n (%) n (%)
18-28 years 1 (20.0%) 2 (40.0%) 2 (40.0%) 5 (100.0%)
29-39 years 0 (0.0%) 6 (75.0%) 2 (25.0%) 8 (100.0%)
40-50 years 5 (31.2%) 5 (31.2%) 6 (37.5%) 16 (100.0%)
51-61 years 2 (33.3%) 2 (33.3%) 2 (33.3%) 6 (100.0%)
62-72 years 2 (40.0%) 1 (20.0%) 2 (40.0%) 5 (100.0%)
Total 10 (25.0%) 16 (40.0%) 14(35.0%) 40 (100.0%)

Table 4: Relationship between age and size of the periapical lesions.

There was no difference between men and women (Table 4), and the fourth and fifth decades of life were the most affected (Table 3). According with the distribution of the periapical lesion by teeth and gender was the maxillary lateral incisor in men with high scores, p= 0.339 (Tables 2, 5 and 6).

Tooth Male Female Total
n (%) n (%) n (%)
8 0 (0.0%) 3 (7.5%) 3 (100.0%)
7 5 (12.5%) 2 (5.0%) 7 (100.0%)
6 1 (2.5%) 0 (0.0%) 1 (100.0%)
5 0 (0.0%) 1 (2.5 %) 1 (100.0%)
4 1 (2.5%) 4 (10.0%) 5 (100.0%)
3 0 (0.0%) 1 (2.5%) 1 (100.0%)
9 2 (5.0%) 2 (5.0%) 4 (100.0%)
10 1 (2.5%) 2 (5.0%) 3 (100.0%)
11 0 (0.0%) 1 (2.5%) 1 (100.0%)
12 1 (2.5%) 1 (2.5%) 2 (100.0%)
13 1 (2.5%) 2 (5.0%) 3 (100.0%)
14 0 (0.0%) 3 (7.5%) 3 (100.0%)
24 0 (0.0%) 2 (5.0%) 2 (100.0%)
23 1 (2.5%) 0 (0.0%) 1 (100.0%)
19 0 (0.0%) 1 (2.5%) 1 (100.0%)
18 1 (2.5%) 0 (0.0%) 1 (100.0%)
31 0 (0.0%) 1 (2.5%) 1 (100.0%)
Total 14 (35.0%) 26 (65%) 40 (100.0%)

Table 5: Relation between Gender and affected tooth.

Tooth Granuloma Cyst Abscess Total
n (%) n (%) n (%) n (%)
8 3 (100.0%) 0 (0.0%) 0 (0.0%) 3 (100.0%)
7 3 (50.0%) 3 (50.0%) 0 (0.0%) 6 (100.0%)
6 1 (100.0%) 0 (0.0%) 0 (0.0%) 1 (100.0%)
5 1(100.0%) 0 (0.0%) 0 (0.0%) 1 (100.0%)
4 4 (80.0%) 1 (20.0%) 0 (0.0%) 5 (100.0%)
3 0 (0.0%) 1 (100.0%) 0 (0.0%) 1 (100.0%)
9 1 (25.0%) 2 (50.0%) 1 (25.0%) 4 (100.0%)
10 1 (33.3%) 0 (0.0%) 2 (66.6%) 3 (100.0%)
11 1 (100.0%) 0 (0.0%) 0 (0.0%) 1 (100.0%)
12 2 (100.0%) 0 (0.0%) 0 (0.0%) 2 (100.0%)
13 2 (50.0%) 1 (25.0%) 1 (25.0%) 4 (100.0%)
14 3 (100.0%) 0 (0.0%) 0 (0.0%) 3 (100.0%)
24 1 (50.0%) 0 (0.0%) 1 (50.0%) 2 (100.0%)
23 1 (100.0%) 0 (0.0%) 0 (0.0%) 1 (100.0%)
19 0 (0.0%) 0 (0.0%) 1 (100.0%) 1 (100.0%)
18 1 (100.0%) 0 (0.0%) 0 (0.0%) 1 (100.0%)
31 0 (0.0%) 0 (0.0%) 1 (100.0%) 1 (100.0%)
Total 25 (62.5%) 8 (20.0%) 7 (17.5%) 40 (100.0%)

Table 6: Relation between tooth and root canal treated.

Relation between age and the quality of the root canal treatment showed no statistical relevance (Table 7).

Group of Age Short Overfill Fractured Instrument Total
  n (%) n (%) n (%) n (%)
18-20 years 3 (60.0%) 1 (20.0%) 1 (20.0%) 5 (100.0%)
29-39 years 3 (27.3%) 5 (45.5%) 3 (27.3%) 11 (100.0%)
40-50 years 5 (33.3%) 9 (60.0%) 1 (6.7%) 15 (100.0%)
51-61 years 2 (40.0%) 3 (60.0%) 0 (0.0%) 5 (100.0%)
62-72 years 0 (0.0%) 4 (100.0%) 0 (0.0%) 4 (100.0%)
Total 13 (32.5%) 22 (55.0%) 5 (12.5%) 40 (100.0%)

Table 7: Differences between quality of root canal and Patient’s age.


The most common periapical lesions of endodontic origins are periapical abscess, granuloma, and cysts (Figures 1-3), all these periapical pathoses, with different treatment and prognostic implications considered clinically suggestive of apical periodontitis, must be confirmed by histopathological examination [40,41].


Figure 1: Periapical Granuloma.


Figure 2: Periapical Cyst.


Figure 3: Periapical Abscess.

Because microorganisms are the essential etiological agents of primary apical periodontitis [42] and also the major cause of post treatment apical periodontitis [43]. The cherished goal of treatment of the disease has been a total elimination of the intraradicular infection and prevention of reinfection [44,45].

These observations are fully in accordance with similar findings reported before [46]. According with Pellegrino [47] patients with post treatment apical periodontitis are faced with contrasting alternatives, including nonsurgical or surgical management intended to cure and retain the affected tooth.

All the samples examined in the present study were obtained during endodontic surgery by the first authors using strict clinical inclusion and exclusion parameters from teeth with persistent apical pathology.

The incidence of periapical cysts among periapical lesions varies from 6% [48] to 55% [49]. In the present study, more than half of the periapical lesions analyzed had a final diagnosis of periapical granuloma cyst (53%), and periapical cyst represented 20% (n=8) of the cases.

This study did not examine the cystic lesions to determine whether they were a true cyst or a bay/periapical pocket cyst because in the majority of cases root apices were not included in the biopsy material and the material often was not able to be removed in total, as such a true representation of the type of cyst could not be reliably made [50].

Matsumato et al. [29] reported that the prognosis for the treatment of large periapical lesions was not as good as that of small lesions. Harrison and Juroski [51] state that if the lesion is small then all the pathologic tissue can easily be removed; however, if the lesion is large, then it is more likely that curettage will be incomplete, and thus unsuccessful.

On the other hand, Rahbaran et al. [52] suggest that the lesion size has no significant influence on the success of treatment. Likewise, Strindberg [53] and Sjögren et al. [20] found no significant differences in healing frequency between lesions initially larger or smaller than 5 mm.

It is clear that the prognosis for a periapical lesion depends on its origin, type and radiographic size and the ultimate success of endodontic surgery is dependent on a myriad of factors. These include the quality of the orthograde root canal filling, the apical root-end filling, size of the periapical destruction, experience of the operator, the type of periapical pathology, use of antibiotics, status of the coronal restoration and the method of preparing the apical root-end cavity [54,55].

The patient’s systemic condition to the history of the individual teeth, case selection, surgical materials and techniques, and the surgeon’s interpretation of the short and long term clinical and radiographic findings are other points to consider [56].

An accurate histopathological diagnosis was only possible when the lesion was removed as a whole, and if a serial sectioning or stepserial sectioning was performed. According with Nair et al. [35] this is possible because in a routine histological report, the presence of an epithelialized lesion is reported as a radicular cyst, but often this report is inappropriate.


The outcomes of the present study show a high number of periapical granulomas among periapical cysts and confirms that periapical granulomas and cysts are the most common periapical lesions of endodontic origin associated with persistent periapical pathosis.

However, other studies have shown a different perspective in the diagnosis of periapical cysts, and more prospective studies are necessary for better clarification of these data. Moreover, this study highlights the importance of the histopathological evaluation for a proper diagnosis of periapical pathosis.


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