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Retrospective Analysis of Biological and Technical Complications Using Individual CAD/CAM Abutments

Ali-Reza Ketabi1*, Sandra Ketabi1, Martin Brenner1, Hans-Christoph Lauer2 and Silvia Brandt2

1Medical Dentistry, Private Practice, Epplestr. 29a, Stuttgart, Germany

2Department of Prosthodontics, University Frankfurt am Main, Frankfurt am Main, Germany

*Corresponding Author:
Dr. Ali-Reza Ketabi
Professor and Doctor of Medical Dentistry, Chairmen of Department of Prosthodontics
Center of Dentistry, Oral Medicine and Maxillofacial Surgery, University of Tuebingen, Germany
Tel: +49 711 – 4400952
Fax: +49 711 – 63 39 69 78
E-mail: [email protected]

Received date: August 07, 2017; Accepted date: August 24, 2017; Published date: August 31, 2017

Citation: Ketabi AR, Ketabi S, Brenner M, Lauer HC, Brandt S (2017) Retrospective Analysis of Biological and Technical Complications Using Individual CAD/CAM Abutments. Dentistry 7:449. doi: 10.4172/2161-1122.1000449

Copyright: © 2017 Ketabi AR, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Purpose: The aim of the present study was to assess the biological and technical complication and survival rates of implants and prosthetic superstructures using custom-milled CAD/CAM abutments made of titanium or zirconia. Material and Methods: A total of 109 patients were treated with 225 AstraTech OsseoSpeed implants (Dentsply IH) between July 2008 and November 2012 in the same private dental practice. Following submerged healing, the implants were uncovered and restored with Atlantis custom CAD/CAM abutments made of zirconia or titanium. Single crowns, fixed bridges, or telescope crowns as attachments for removable prostheses were connected to the abutments with zinc oxide phosphate cement. Patients were clinically and radiologically followed at the abutment level for a mean 20.85 months. The clinical assessment included biological and technical complications a well as the survival of the implants, abutments, and prosthetic superstructures. Mean crestal bone loss was assessed on standardized radiographs. Patient satisfaction was surveyed with a self-developed questionnaire. Results: The records of 69 patients (49 female, 20 male: mean age: 53.51 years) treated with 124 implants/custom abutments were included in the final analysis. Most abutments were made of titanium (n=90), followed by zirconia (n=34). The survival rates of implants and abutments were 100.00%. Eight restorations (6.50%) had to be replaced during follow-up, for an implant/abutment-related cumulative prosthetic success rate of 93.50%. The patient-related cumulative prosthetic survival rate was 92.75%. A mean bone gain of 0.06 mm (SD: 0.28 mm) on the mesial side and 0.11 mm (SD: 0.37 mm) at the distal side of the implants (n=122) was recorded. Only a few cases of soft-tissue complications such as mucositis, loss of papilla height, or bleeding on probing were observed. Therapy was rated as very good by 92.65% of patients. The esthetic result was assessed as very good as well by the majority of patients (88.41%). Due to the small sample size, no tests for statistical significance could be performed for any of the examination parameters, except for radiological crestal bone loss. No statistical significance was found for crestal bone loss as a function of the abutment material (p ≥ 0.05). Conclusions: Individual CAD/CAM -abutments are a good and predictable treatment option and deliver high patient satisfaction concerning the therapeutic and esthetic results.


Custom abutments; Emergence profile; CAD/CAM; Softtissue management; Implant prosthetics


Abutments are important as links between implants and the prosthetic superstructure. They are also a very important determinant for biological, technical, and esthetic parameters. Improving the connection between implant and abutment to reduce and prevent micromovements at the implant-abutment interface should therefore be a top priority in oral implantology [1]. The stability of peri-implant hard- and soft-tissue conditions is fundamental to long-term implant success and crucial for peri-implant esthetics, especially in the anterior jaw [2]. Nonetheless, remodeling of the crestal bone during the first years after implant insertion seems to be an inevitable side effect [3,4].

Why bone undergoes remodeling is still unclear. Influencing parameters — such as flap vs. flapless technique [5,6], implant position, the positioning of the microgap between abutment and implant (supracrestal, epicrestal, or subcrestal) [7], or abutment diameter (platform switching/platform shifting) [8-10] — have been proposed but not yet proven. Material-specific surface properties of the implant and abutment also seem to have an influence on the healing process and the biological reaction of the peri-implant hard and soft tissues.

In an in vitro study, smooth metallic surfaces of biomaterials promote epithelial cell adhesion and cell spreading more than surfaces made of dental ceramic materials [11]. The current literature reveals no significant or clinical differences in survival rates, technical and biological complications, soft-tissue parameters, radiological bone loss, esthetic parameters, or patient-reported outcomes around abutments made of titanium or zirconia [12], However, zirconia abutments seem to deliver better esthetic results than abutments made of titanium [12,13]. Titanium and zirconia surfaces both promote the establishment of hemidesmosomal connections between epithelial cells and abutment surface, building a mucosal barrier similarly to the junctional epithelium around natural teeth [14,15], which is one of the main targets of hard- and soft-tissue preservation in implant therapy [16].

There seem to be no significant differences in crestal bone resorption a function of the abutment material, whether alumina, zirconia, titanium, or gold alloys [17]. Platform-switching (or platform-shifting) is assumed to result in significant reduced bone remodeling and better preserved soft tissue than abutments with a matching standard diameter [8,10,18-22].

More recent animal studies and systematic reviews have shown confusing results in that they failed to demonstrate a positive influence of reduced-diameter abutments on peri-implant tissue stability [4,23,24]. In addition to the biocompatibility of implant and abutment materials and the functional integrity of the implant-abutment interface, an emergence profile that mimics the natural tooth seems to have a substantial impact on the esthetic and functional epithelial cuff that forms around the implant neck. An optimal emergence profile can be achieved when the peri-implant mucosa is shaped formed very early by a provisional abutment [25-30].

Physiologically shaped formed provisional and final abutments created using computer-aided design/computer-aided manufacturing (CAD/CAM) seem to be a highly promising approach to shaping the ideal emergence profile [26,27]. CAD/CAM systems for the fabrication of individual abutments facilitate custom production of esthetically shaped abutments made of different materials such as pure titanium, titanium anodized with titanium nitride (Gold Hue), or zirconia [31-37].

CAD/CAM abutments are more precise than those created by conventional casting and fit more precisely than stock abutments [38]. A radiographic and scanning electron microscopic (SEM) assessment revealed no differences between custom and prefabricated titanium abutments by Dentsply IH with respect to their microscopic and radiographic fit at the implant-abutment interface [39]. Customdesigned Atlantis abutments (Dentsply IH) are available for all major implant systems including the Astra Tech Implant System. There are notable benefits to the Atlantis system in addition to its low cost [33,40], such as reduced overall treatment times [33,41,42], and a simplified treatment protocol [33,40].

A recently published systematic review reported the highest survival rates for implant-supported single crowns, followed by fixed partial dentures, over a follow up period of five years [43]. Despite the favorable survival rates over five years, technical, biological, and esthetic complications with respect to implant-supported fixed restorations seem to be relatively frequent [44]. While prosthodontic failure rates as a function of the retention mechanism used do not show any statistical difference between screw-retained and cemented restorations [45-48], both methods are associated with issues related to prosthodontic maintenance and complications [48]. The distribution of complication types seems to differ depending on the retention type: whereas screw-retained fixed prosthetic reconstructions showed a significantly higher incidence of technical complications, cemented reconstructions seemed to imply more biological problems [46-48].

With regard to the complication and survival rates of hybrid prosthetic superstructures on both natural teeth and implants, older systematic overviews reported lower survival rates for hybrid reconstructions [49,50] and complained of the lack of longitudinal studies [50]. However, more recent reviews showed similar rates of technical complications with hybrid reconstructions as with strictly implant-supported fixed dentures if rigid functional connections between implants and natural teeth were used [51]. Despite similar complication rates, failure rates seem to be higher for fixed hybrid superstructures than for implant-supported single crowns or fixed partial prostheses [52]. The aim of the present study was to assess the biological and technical complication and survival rates of implants and prosthetic superstructures using custom-milled CAD/CAM abutments made of titanium or zirconia.

Methods and Materials

The present retrospective cohort study included 109 consecutive partially edentulous patients treated with 225 CAD/CAM Atlantis abutments between July 2008 and November 2012. Clinical and radiological parameters were assessed and documented by means of a self-developed questionnaire. Patient satisfaction in terms of esthetics and treatment results was assessed with a self-developed questionnaire as well. The study was approved by the competent Ethics Commission of the Medical Chamber of the German State of Baden-Württemberg (2013/04/09).


Implant treatment had been performed previously, between April 2008 and September 2012, using 225 Astra Tech OsseoSpeed implants (Dentsply IH) after reflecting a full-thickness flap. Implants with lengths of 6 to 13 mm and diameters of 3.5 to 5 mm were inserted in the anterior and/or posterior part of the maxilla or mandible, followed by submerged healing for 2 to 6 months.

All implants were inserted using a conventional/late placement protocol, as suggested by the 4th ITI Consensus Conference [53]. The healing phase was extended if augmentation procedures with a bovine bone substitute (Bio-Oss; Geistlich Biomaterials) and guided bone regeneration (GBR) (Bio-Gide; Geistlich Biomaterials) had to be performed in conjunction with the insertion of the implant. After uncovering the implants, standard healing abutments provided by the manufacturer were used until the final restoration was fabricated and inserted. Clinical and radiological parameters were assessed one year after definitive delivery.


Abutments were fabricated using the Atlantis Virtual Abutment Design Software (VAD) (Dentsply IH). They were made of either titanium (Figure 1), zirconia (Figure 2), or GoldHue (Figure 3). The system offers different options for a customized design of the abutments’ emergence profile depending on the anatomic situation, as well as the possibility to compensate the position of implants with a prosthetically unfavorable placement through different angulations for the abutments. The basis for the milling process, performed by the manufacturer of the VAD software, was a 3D scan of a plaster cast with a silicone gingival mask (Picodent Dental) and a wax-up around the duplicate abutments in the respective implant regions. The clinician determined the abutment design by entering the instructions in a special virtual order form and sending the data to the manufacturer over the internet.


Figure 1: Atlantis abutment made of titanium.


Figure 2: Atlantis abutment made of zirconia.


Figure 3: Atlantis abutment made of GoldHue.

The finished milled abutment was delivered to the practitioner with a corresponding abutment screw made of a titanium alloy. The definitive prosthetic restauration was fabricated by the dental technician. All abutments in the study were fabricated as described. The abutments were connected positioned with the help of a resin transfer key made by the technician and inserted at the torque recommended by the manufacturer. For the analysis of the materialspecific influence of the different abutments on clinical and radiological parameters, abutments made of GoldHue were assigned to the group of titanium abutments because of their identical material properties.

Prosthetic superstructure

The patients received cemented crowns and/or bridges made of veneered zirconia — Ceramill ZI (Amann Girrbach) or IPS e.max Press (IPS e.max, Ivoclar Vivadent) — or dentures retained by metalceramic and removable telescope crowns. All fixed superstructures were cemented with zinc oxide phosphate cement. The bridges were supported either by implants alone or by implants and natural teeth (hybrid bridges).

Inclusion criteria

The inclusion criteria for participation in the cohort study were as follows:

• At least one implant with an Atlantis abutment and a crown

• At least one follow-up examination one year after functional loading

• Documentation of clinical and radiologic parameters for a minimum of two years after delivery of the prosthetic superstructure

Radiologic parameters

Panoramic radiographs were obtained for pre-implantological diagnosis using the Orthophos D 3297 (Sirona Dental Systems). Conventional radiographs were taken at three different times using the parallel technique with a Sirona SR 60/70/7L tube. The first radiograph was taken immediately after implant placement in order to verify the insertion outcome. The second radiologic examination was performed at the time of delivering the final prosthetic restauration (baseline). The third radiograph was taken one year after functional loading of the implant (Figure 4).


Figure 4: Conventional radiograph in parallel technique after one year of functional loading.

All radiographs were scanned with the VistaScan scanner (S/N P000098; Dürr Dental) using the filtering functions of the original Dürr Dental software. The radiographs were edited (brightness adjustments, recalculation of image distortion, and magnification of image sections), and measurements were performed for final analysis.

Method of measurement

Because of its good radiological visibility, the implant shoulder was selected as the reference point for identifying changes in the crestal bone and measuring bone loss (Figure 5).


Figure 5: Implant reference points for the assessment of crestal-bone changes.

Two measurements were performed for each implant:

• Implant length, measured from the reference point to the apex of the implant or, alternatively, the length of the microthread (defined as the distance from the reference point to the end of the thread at the implant neck) if the implant was not displayed on the radiograph in its entirety.

• Bone levels on the mesial and distal side of the implant. This measurement was performed parallel to the implant axis from the point of reference to the first bone-to-implant contact (BIC). Any crestal bone loss or gain was reflect by negative or positive numbers, respectively. Radiographic distortion was detected and compensated for by the software, based on a comparison of known and measured implant dimensions.

The measurements were performed by a single examiner in a darkened room. To prevent the measuring accuracy from being affected by examiner fatigue, measurements were determined for a consecutive maximum of two hours. Each measurement was immediately documented in the data entry form; to avoid bias; it was repeated on a different day.

Clinical parameters

Soft-tissue conditions and the status of the prosthetic restauration were recorded at baseline and after one year in function. Soft-tissue quality was evaluated based on the mesial and distal height of the papilla and the color of the mucosa. Changes in papilla height were compared visually on photographs taken at baseline and at the followup. Changes in papillary soft-tissue levels were documented on an ordinal scale, with –1 denoting a height loss, 0 denoting no changes in papilla level, and 1 a height gain. Inflammation was assessed by a dichotomous variable (no=0; yes=1) for the composite parameter bleeding on probing, pain, and suppuration. Suppuration was detected by gentle pressure on the marginal peri-implant mucosa with a ballshaped dental instrument.

Prosthetic dentures were examined for any missing occlusal and approximal contacts or chipping of the ceramic veneer with and without exposure of the denture framework.

Patient documentation form and questionnaire

A self-developed form was used for documenting the respective clinical and radiological parameters. Another self-developed questionnaire was used to determine subjective patient-specific parameters regarding the treatment and esthetic considerations.

Statistical methods

All parameters were recorded with in Microsoft Excel (Microsoft Corporation) and the statistical analyses were performed with the Statistical Package for the Social Sciences (SPSS) Version 24 (International Business Machines). The level of significance was set to α=0.05. Due to the small sample size, no significance testing could be performed, except regarding radiological changes in crestal bone levels as a function of the abutment material (Mann-Whitney U test).


After a mean observation period of 20.85 (SD: 9.77) months, clinical and radiological data for 69 patients (49 female, 20 male) with 124 implants were available for analysis. Their mean age was 53.51 (29–78) years. Most of the abutments used in this study, were made from titanium (n=87; 70.20%). Thirty-four abutments were fabricated of zirconia (27.40%) and three were made of GoldHue (2.42%) (Table 1).

Abutment material Frequency Percent
Titanium 87 70.16
Zirconia 34 27.42
GoldHue 3 2.42
Total 124 100

Table 1: Distribution of abutment material (124 abutments).

Prosthetic reconstructions made of zirconia were connected to 87 abutments (70.16%) while metal-ceramic restorations were placed on 13 abutments (10.48%). Materials other than zirconia or metalceramics (e.max or monolithic zirconia) were used on 24 abutments (19.36%) (Table 2).

Material of prosthetic superstructure Frequency Percent
Zirconia 87 70.16
Metal ceramics 13 10.48
Others (e.max, monolithic zirconia) 24 19.36
Total 124 100

Table 2: Distribution of the material of prosthetic superstructures.

Single implant-supported crowns were the most frequent prosthetic superstructures inserted in this study (n=88; 70.97%), followed by fixed partial bridges on 27 abutments (21.77%). Hybrid bridges supported by implants and natural teeth were used on five abutments (4.03%), and removable dentures were supported by four abutments by means of telescope crowns (3.23%) (Table 3).

Prosthetic superstructure Frequency Percent
Single crowns 88 70.97
Bridges (only implant-supported) 27 21.77
Hybrid bridges (implant-/tooth-supported) 5 4.03
Removable dentures 4 3.23
Total 124 100

Table 3: Prosthetic superstructures.

Of the 27 abutments placed in the esthetic zone, 21 abutments were made of zirconia (77.77%), while the other 6 were made of titanium (22.22%).

No implants or abutments were lost during the main observation period, resulting in a survival rate of 100.00% on the patient, implant, and abutment levels.

Crestal bone level changes

Of the 124 implants/abutments, 122 were available for an analysis of the changes in mean crestal bone levels one year after implant insertion. Changes around 2 implants in 2 patients could not be analyzed due to measuring difficulties at the time of implant insertion. One of these 2 implants had received a titanium abutment, while the other one had received a zirconia abutment. The mean bone level at baseline on the mesial and distal sides of the implants was 0.56 and 0.31 mm, respectively. At the second measurement, the mean bone level on the mesial and distal sides of the implants was 0.61 and 0.42 mm, respectively, for an overall mean crestal bone gain of 0.06 ± 0.28 mm on the mesial sides and 0.11 ± 0.37 mm on the distal sides of the 122 implants (Table 4).

Bone level Mean SD Mean bone-level change SD p value
Baseline mesial 0.56 0.58   0.06   0.28   0.550
One-year mesial 0.62 0.62
Baseline distal 0.31 0.54   0.11   0.37   0.050
One-year distal 0.42 0.60

Table 4: Mean bone-level changes after one year (122 abutments).

A statistical significant influence of the abutment material on crestal bone levels could not be radiologically assessed either on the mesial (p=0.550) or on the distal side (p ≥ 0.05) of the implants (Mann- Whitney U test).

Biological complications

Changes in papilla height were recorded as an ordinal variable (– 1=loss; 0=no change; +1=gain of papilla height). Gain in papilla height on the mesial and distal side as well could be observed after the observation period in the most cases at the abutment level (n=117) and at the patient level (n=65). Five abutments in four patients showed no changes in papilla height. Two abutments in one patient (sites 15 and 16) revealed a loss of papilla height. Bleeding on probing (BOP) was recorded on the distal and mesial side of both implants (1.45%). Crestal bone loss occurred here on the distal side of implant 15 (1.00 mm), and on both the mesial (1.50 mm) and distal aspects (1.00 mm) of implant 16, whereas no bone loss was found on the mesial side of implant 15. Another soft-tissue complication, namely reddening of the mucosa around a zirconia abutment, was observed in another patient in the esthetic zone of the maxilla (site 22) but without any clinical/ radiological consequences for the hard and soft tissues (1.45%).

Technical complications

None of the technical complications were associated with biological complications or crestal bone loss. No abutment fractures and no loosening or fractures of abutment screws were seen. Other technical complications in terms of veneer fractures were observed in two patients. In one patient, the veneer of four implant-supported zirconia single crowns in the left posterior maxilla exhibited chipping. Three crowns (24, 25, and 26) were involved but without framework exposure (2.46%), whereas the veneering material of the implant-supported crown 27 fractured and exposed the framework. In the second patient there was also a fracture with framework exposure in the posterior maxilla at implant 27. The total fracture rate with framework exposure was 1.64%. Five restorations in four patients showed insufficient occlusal contacts (4.00%). One restoration revealed an insufficient proximal contact situation on the mesial side (0.80%), and a proximal contact in another patient was too tight (0.80%).

In total, eight restorations had to be replaced in five patients. Four restorations were replaced in the patient exhibiting fractures with and without framework exposure. The fractured restoration in the second patient, with framework exposure, remained in place at the patient’s request. The two restorations in the patient with biological complications at sites 15 and 16 were also replaced. An additional two restorations were replaced in a patient who was dissatisfied with the therapeutic and esthetic result.

Based on these findings, the cumulative prosthetic survival rate at the abutment and implant levels was of 93.50%. At the patient level, the cumulative survival rate of the superstructures was 92.75%. The implant and abutment survival rate was 100.00%.

Patient satisfaction

The majority of patients showed a very high degree of satisfaction with the therapy in principle and with the aesthetic result of the prosthetic superstructure after one year in function. The treatment was rated as very good by 63 (92.65%) and as food by 4 (5.88%) patients out of 68. The esthetic result rate as was estimated as very good 61 (88.41%) and as good by 7 (10.14%) patients out of 69. Only one patient was disaffected with the therapeutic (1.47%) and the esthetic result (1.45%), although neither biological nor technical complications were present in this patient (Table 5).

Esthetics Therapy
Rating Frequency Percent Frequency Percent
Very good 61 88.41 63 92.64
Good 7 10.14 4 5.88
Pleasible 0 0 0 0
Acceptable 0 0 0 0
Poor 1 1.45 1 1.47
Total 69 100 68 100

Table 5: Results of the patient questionnaire, n=69 patients (one patient did not rate his satisfaction with the therapeutic result).

The same patient had received two abutments and crowns made of zirconia in the esthetic maxillary esthetic zone (sites 21 and 23). Both crowns were replaced due to his displeasure with the therapeutic and esthetic result. However, the patient who had experience three veneer fractures without and one veneer fracture with framework exposure rated the esthetic and therapeutic result as very good. The patient with the exposed framework after fracture of the superstructure also rated esthetics and therapy as very good.


The impact of the material properties of zirconia and titanium on the therapeutic and esthetic results in implant prosthetics has been the subject of many recent papers. With respect to esthetics, evidence of a material-related influence is still uncertain. Both materials exhibited significant shade differences in the peri-implant soft tissue compared to adjacent natural teeth in a randomized controlled clinical trial (RCT) [13]. Significant shade differences between titanium and zirconia abutments were found within 1.00 mm of the gingival margin prior to crown cementation in the same study. Differences between the two materials were still present after cementation, but these differences were not statistically significant. A different publication, by contrast, reported significantly lower shade differences with zirconia abutments compared to titanium and GoldHue abutments [54]. A systematic review confirmed a significant trend toward better esthetic outcomes around zirconia abutments [12], while the results of another systematic review revealed no esthetic differences between zirconia and titanium abutments [55].

In the present study, the majority of patients were highly satisfied with the esthetic treatment outcome. Due to the very small number of GoldHue abutments and the still relatively small number of zirconia abutments compared to the many titanium abutments, no test for statistical significance concerning satisfaction with the esthetic result as a function of the abutment material could be performed. Given the high level of patient acceptance, even though most abutments in the present study were made of titanium, the abutment material might be negligible as a factor influencing patients’ perception of esthetics.

Based on the results of a recent clinical study, patients tend to be more satisfied with the esthetic result in terms of restoration shade than the clinician [54]. As the assessment was made using a five-point scale that reflected the patients’ subjective opinions rather than being supported by objective parameters such as colorimeter [13] or spectrophotometry readings [55], the reliability of the questionnaire results might questioned. Assessments of a recent RCT published by Ferrari et al. revealed a low incidence of soft-tissue complications and no significant differences between titanium, GoldHue, and zirconia with respect to complications in the peri-implant tissue, such as midfacial recession in partially edentulous patients, irrespective of the patients’ gingival phenotypes [56].

Although no statistical analysis of the material’s influence on softtissue parameters and biological complications was possible in the cohort study, we observed a very low incidence of soft-tissue complications, confirming the results of the study by Ferrari et al. Softtissue complications were recorded only in a few cases, manifesting as redness of the peri-implant mucosa in one case and as bleeding on probing and a loss of papilla height in another patient. Crestal bone loss was observed in conjunction with the loss of papilla height in the same patient. No significant influence of the material on the soft or hard tissue was observed. This finding agrees with the results of a systematic review by Linkevičius and Apse that revealed no influence of the abutment material on hard-tissue levels [17].

Bone levels increased in the present study through the follow-up. This finding is not supported by current scientific evidence, which in principle suggests bone remodeling takng place in connection with implant placement, resulting in crestal bone loss after the first postsurgical year [57-59]. Neither implant loss nor implant-related complications were observed, resulting in a survival rate of 100.00% for implants and abutments and a complication rate of 0% after one year in function, which is better than or equal to the results reported elsewhere [60,61].

The incidence of technical complications such as veneer fractures was also very low. The fracture rate seemed to depend on the specific patient situation, because four of the five fractures occurred in one and the same patient. In total, eight restorations had to be replaced due to technical or esthetic problems, for a cumulative prosthetic survival rate of 93.50% on the implant and abutment levels. The high survival rate in the present study is comparable with the results in other publications [44,43,62].


Because only custom CAD/CAM abutments were used in the present cohort study, no comparison to stock abutments was performed, which somewhat limits the information value of our results and does not allow the postulation of additional CAD/CAM-related benefits in terms of functional and esthetical outcomes.

Yet despite these limitations, the low complication rates in the present study and the high level of patient satisfaction with implantsupported prosthetic superstructures supported by CAD/CAM abutments after one year in function is very promising and would support the treatment concept and protocol presented.


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