Serum Uric Acid Levels: A Potential Biomarker for the Acute Myocardial
Infarction in Hypertensive Patients
Francisco Sandro Menezes-Rodrigues1, Luciana de Paula2, Paolo Ruggero Errante1, Afonso Caricati-Neto1 and Leandro Bueno Bergantin1*
1Department of Pharmacology, Escola Paulista de Medicina, Universidade Federal de São Paulo (UNIFESP), Brazil
2Laborvisa Laboratório de Análises Clínicas, São Paulo, Brazil
- Corresponding Author:
- Dr. Leandro Bueno Bergantin
Department of Pharmacology
Escola Paulista de Medicina-Universidade Federal de São Paulo–EPM/UNIFESP
São Paulo-SP, Brazil
E-mail: [email protected]
Received Date: May 04, 2017; Accepted Date: May 08, 2017; Published Date: May 12, 2017
Citation: Bergantin LB (2017) Serum Uric Acid Levels: A Potential Biomarker for the Acute Myocardial Infarction in Hypertensive Patients. J
Thrombo Cir 3:e107. doi:10.4172/2572-9462.1000e107
Copyright: © 2017 Menezes-Rodrigues FS, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Visit for more related articles at Journal of Thrombosis and Circulation: Open Access
Cardiovascular diseases (CD) are one of the main causes of death in
the world, among them is ischemic cardiac disease (ICD). ICD is
believed to cause 26 million deaths worldwide by 2030 [1,2]. Among
ICD, acute myocardial infarction (AMI) is the most common cause of
morbidity and mortality in the world [2,3]. AMI is characterized by a
long period, and severe, of cardiac ischemia (e.g. thromboembolism)
that promotes large myocardial damage. The treatment of cardiac
ischemia is aggravated by reperfusion (e.g. revascularization) which
compromises cardiac function, especially the excitation-contraction
coupling mechanism [2-4].
The diagnosis of AMI is performed through the analysis of several
parameters, among them are the measurements of biochemical serum
markers of cardiac lesion. Currently, the most used in the medical
clinic for this purpose is the total creatine kinase (CK), and creatine
kinase MB fraction (CK-MB), as well as troponins I and T proteins
(TnI and TnT) .
The increased concentration of uric acid (UA) in serum, a
metabolite of purines degradation produced by activity of xanthine
oxidase enzyme, serves as an independent risk factor for
cardiovascular disease [6-11]. Indeed, the UA has been related to
inflammation, endothelial dysfunction and deterioration of left
ventricular function via changing calcium sensitivity of myofilaments,
alterations of myocardial energetic metabolism, thus serving as major
prognostic marker predicting mortality, and needful for heart transplantation in patients with progressive heart failure [12,13]. In
addition, the UA has been used alone, or in combination with other
parameters (e.g. serum biomarkers and clinical), as a predictor for
coronary heart disease, and managing of the cardiac patient .
Moreover, UA has been related to the increased of blood pressure of
the children and adolescents , and adults [16,17].
Our group currently studies the alterations of excitation-contraction
coupling mechanisms of cardiac cells submitted to ischemiareperfusion
injury in animal model of hypertension, by using the
model of spontaneously hypertensive rats (SHR) and normotensive
Wistar rats (NWR), with emphasis in serum markers of cardiac injury
. We found that hypertension does not increase serum levels of UA
in SHR group when compared to NWR. However, we observed
increased serum levels of UA in the SHR group submitted to cardiac
ischemia and reperfusion, compared to NWR, suggesting a possible
relevance of this marker in human hypertensive patients in the
condition of cardiac ischemia and reperfusion.
As conclusion, we suggest that UA could be used in combination
with other cardiac injury markers for the diagnosis of acute myocardial
infarction in hypertensive patients.
Research supported by CNPq, FAPESP and CAPES.
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