alexa Short commentary on Lymphedema after Treatment for Endometrial Cancer | Open Access Journals
ISSN: 2161-0932
Gynecology & Obstetrics
Like us on:
Make the best use of Scientific Research and information from our 700+ peer reviewed, Open Access Journals that operates with the help of 50,000+ Editorial Board Members and esteemed reviewers and 1000+ Scientific associations in Medical, Clinical, Pharmaceutical, Engineering, Technology and Management Fields.
Meet Inspiring Speakers and Experts at our 3000+ Global Conferenceseries Events with over 600+ Conferences, 1200+ Symposiums and 1200+ Workshops on
Medical, Pharma, Engineering, Science, Technology and Business

Short commentary on Lymphedema after Treatment for Endometrial Cancer

Madelene Wedin1*, Emma Lindqvist2, Mats Fredrikson3,4 and Preben Kjølhede1

1Department of Obstetrics and Gynecology, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden

2Department of Obstetrics and Gynecology, the Highland Hospital, Eksjö, Sweden

3Forum Östergötland, Faculty of Medicine and Health Sciences, Linköping University, Linköping, Sweden

4Occupational and Environmental Medicine, Department of Experimental and Clinical Medicine, Faculty of Health Sciences, Linköping University, Linköping, Sweden

*Corresponding Author:
Dr. Madelene Wedin, MD
Department of Obstetrics and Gynecology
University Hospital, S-58185 Linköping, Sweden
Tel: +46(0)10103 0000
Fax: +46(0)13148156
E-mail: Madelene.Wedin@regionostergotland.se

Received date: June 21, 2017; Accepted date: June 27, 2017; Published date: June 30, 2017

Citation: Wedin M, Lindqvist E, Fredrikson M, Kjølhede P (2017) Short commentary on Lymphedema after Treatment for Endometrial Cancer. Gynecol Obstet (Sunnyvale) 7:442. doi: 10.4172/2161-0932.1000442

Copyright: © 2017 Wedin M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Visit for more related articles at Gynecology & Obstetrics

Lymphedema development after cancer treatment in women with endometrial cancer is a poorly explored complication and there is a substantial gap in the knowledge of this troublesome treatmentrelated adverse effect. Endometrial cancer is the most common gynecological cancer. The majority of the women diagnosed with endometrial cancer will be long-term survivors. The primary treatment of endometrial cancer most often comprises hysterectomy and bilateral salpingo-oophorectomy. Pelvic and para-aortic lymphadenectomy is recommended in prognostic high-risk groups of endometrial cancer. Lymphedema development is associated with lymphadenectomy.

This short commentary presents a summary of the recently published systematic review article entitled Lymphedema after Treatment for Endometrial Cancer-a review of prevalence and risk factors [1]. The review comprised the sub-items: Prevalence of lower limb lymphedema; Methods for determining the lower limb lymphedema diagnosis; Risk factors for lower limb lymphedema; Follow-up time and onset of symptoms of lower limb lymphedema; and -Impact on quality of life after surgical treatment of endometrial cancer including lymphadenectomy.

The review [1] is a descriptive meta-analysis of literature published on lymphedema development after surgery of endometrial cancer. The review reveals several essential weaknesses in the knowledge of lymphedema after treatment of endometrial cancer. So far, no randomized controlled trials with lymphedema as primary endpoint after treatment of endometrial cancer have been published. The reported prevalence of lymphedema after endometrial cancer treatment are mainly based on retrospective or cross-sectional studies. The reported prevalence vary between zero [2] and 50% [3]. Many of the retrospective studies do not include objective measurements of lymphedema, but report patient complain over swelling legs as lymphedema. Thus, the true prevalence of lower limb lymphedema after treatment of endometrial cancer remains to be established. Several methods to evaluate and categorize lymphedema have been presented but these are not consistently used in studies of endometrial cancer treatment. In addition, in most studies the base line measurement of lymphedema is lacking. The methods used in the studies include subjective scoring systems based on questionnaires, various clinical rating systems, directly or indirectly objective measurement of limb volume, bioimpedance measurements and various imaging techniques such as CT-scan, MRI, lymphoscintigraphy or fluorescent lymphography. Still there seems to be no universally used standardization for how to measure or report lymphedema in scientific contexts, which make comparison of studies difficult. Risk factors remains to be evaluated in correctly designed and sufficiently powered studies. However, lymphadenectomy per se [4-7], number of lymph nodes removed [6,8-16] and radiotherapy [3,7-11,14,17-20] seem to be established risk factor. Lymphedema onset may begin immediately after surgery or may be delayed for many years. Long-term follow-up is therefore necessary in order to establish reliable results on time of onset of lymphedema and to detect lymphedema in order to start early treatment. All published research seems unanimously to conclude that lymphedema is an important factor with adverse effect on quality of life [7,11,21]. We found that much of the shortcomings are based on a fundamental lack of well-designed research and that there is a lack of standardization of terminology and methods of measuring lower limb lymphedema in research.

We conclude that there is a need for unanimous evidence-based international guidelines of terminology and methodology for diagnosis and treatment recommendations of lymphedema. We suggest and encourage the international scientific societies who deal with lymphedema to assemble and agree on international guidelines.

From a clinical point of view it is very important to emphasize that lymphedema is a chronic and progressive condition that, if untreated, can affect the quality of life adversely. It may bring years of suffering to the woman affected and established lymphedema is a serious condition that may be lethal. Today more women with gynecologic cancer become long-term survivors. This strongly increases the demand on the health care to provide adequate and reliable information concerning diagnosis, treatment and outcome including side effects and consequences, and to minimize the adverse impact of side effects of treatment on the health related quality of life.

References

Select your language of interest to view the total content in your interested language
Post your comment

Share This Article

Relevant Topics

Recommended Conferences

Article Usage

  • Total views: 892
  • [From(publication date):
    June-2017 - Sep 23, 2017]
  • Breakdown by view type
  • HTML page views : 838
  • PDF downloads :54
 

Post your comment

captcha   Reload  Can't read the image? click here to refresh

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

agrifoodaquavet@omicsonline.com

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

clinical_biochem@omicsonline.com

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

business@omicsonline.com

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

chemicaleng_chemistry@omicsonline.com

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

environmentalsci@omicsonline.com

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

engineering@omicsonline.com

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

generalsci_healthcare@omicsonline.com

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

genetics_molbio@omicsonline.com

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

immuno_microbio@omicsonline.com

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

omics@omicsonline.com

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

materialsci@omicsonline.com

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

mathematics_physics@omicsonline.com

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

medical@omicsonline.com

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

neuro_psychology@omicsonline.com

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

pharma@omicsonline.com

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

social_politicalsci@omicsonline.com

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords