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1Pathology Unit, IRCCS Arcispedale Santa Maria Nuova Hospital, Reggio Emilia, Italy
2Breast Surgery Unit, IRCSS Arcispedale Santa Maria Nuova Hospital, Reggio Emilia, Italy
Received Date: November 02, 2014; Accepted Date: November 04, 2014; Published Date: November 06, 2014
Citation: Falco G, Ragazzi M (2014) Solid Papillary Carcinoma: A Cytologic-Histologic Correlation of an Uncommon Breast Neoplasm . J Cytol Histol 5:i105. doi:10.4172/2157-7099.1000i105
Copyright: © 2014 Ragazzi M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Cytological smear from a 79 year old women with nipple retraction. Examination with mammography was negative. Ultrasound investigation showed a well-delimited, hypoechogenic nodule, 1.2 cm in greatest axis.
Numerous neoplastic cells arranged in sheets (Figure 1a) and papillary structures (Figure 1b). Cells are quite monomorphic, characterized by peripherally located nuclei and disperse chromatin with inconspicuous nucleoli and abundant granular cytoplasm (Figure 1c). An intracytoplasmic vacuole can be appreciated (Figure 1c, arrow). Mucoid material is evident on May-Grunwald Giemsa stain (Figure 1d).
Figure 1: a) shows stained sections neoplastic cells, b) presents the papillary structures, c) shows monomorphic cells with peripherally located inconspicuous nuclei, dispersed chromatin and the abundant granular cytoplasm, d) Mucoid material visualization.
A mastectomy was performed.
Histological diagnosis: solid papillary carcinoma of the breast (Figure 2).
Figure 2: solid papillary carcinoma of breast.
It is a controversial entity in breast pathology. First described by Maluf and Koerner in 1995 [1] as a type of intraductal carcinoma with endocrine differentiation, precursor of type B mucinous carcinoma, it has been recently referred to as an invasive tumor with low malignant potential [2].
In the latest WHO (2012) is listed as a distinct entity, accounting for less than 1% of breast carcinoma, regarded for staging purposes as a form of in situ carcinoma [3].
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