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Journal of Steroids & Hormonal Science
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Stabilizing Motor Reflexive Activation and Acute Growth Hormone Response: A Systematic Review

John Jaquish*, Henry Alkire and Kevin Hoesley

American Bone Health, Oakland, California, USA

Corresponding Author:
Jaquish J
American Bone Health, Oakland, California, USA
E-mail: [email protected]

Received Date: June 12, 2016; Accepted Date: July 08, 2016; Published Date: July 13, 2016

Citation: Jaquish J, Alkire H, Hoesley K (2016) Stabilizing Motor Reflexive Activation and Acute Growth Hormone Response: A Systematic Review. J Steroids Horm Sci 7:178. doi:10.4172/2157-7536.1000178

Copyright: © 2016 Jaquish J, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Abstract

Objective: Evaluating reflexive (Il and Ia afferent) body-stabilizing activity as a possible mechanism regulating hGH levels.

Data Sources: The authors searched MEDLINE, PubMed, Harvard HOLLIS, and EMBASE databases for studies published through 1 January 2016 by using such terms as: vibration, stability, and human growth hormone.

Study Selection: The authors included randomized, controlled trials and randomized pre-post observational trials that compared acute alterations of hGH in humans with both genders spanning from post-pubescence to elderly populations.

Data Extraction: Three authors independently reviewed articles and abstracted data.

Data Synthesis: PRISMA guidelines were followed with 17 articles describing 24 unique study populations meeting the inclusion criteria. A total of 265 participants who engaged in a destabilizing intervention were assayed both against baseline and control (when present). Populations varied in age, with all populations having a mean age of 35.1 [SD, 13.6], and RCTs of 41.6 [SD, 17.2], with the youngest population being 17.8 [SD, 0.88], and the oldest being 70 [SD, 8.8]. Subjects saw acute increases from pre-to-post of 647% [95% CI, 541% to 753%] (P=0.00001). Test group subjects compared to those subjected to control interventions increased hGH levels by 101% [95% CI, 85.7% to 116%] (P=0.006). Statistical analysis excluded one study that altered its blood sample concentrations via centrifuge.

Conclusions: The literature published on randomized, controlled trials and randomized acute evaluations of reflexive stability recruitment of muscle and hGH in multiple populations is limited but suggests that there is an association with whole body stability firing and hGH levels. On the basis of this evidence, interventions that encourage increases in whole body stability firing can be recommended to illicit increases in hGH levels.

Keywords

Pituitary axis; Muscle afferents; Human growth hormone; Hormone regulation

Introduction

While the link between physical activity and acute growth hormone response has been recognized since the 1960s [1,2], the results of analysis such as that performed by Shaner and researchers in 2014 demonstrates a marked increase over control subjects in hGH excitatory effect for exercises requiring self-stabilization from the subject compared to exercises without that requirement [3]. Further, a functional activity such as sprinting compared with endurance focused running has been shown to attenuate a greater hGH response of 82% [4] and 231% in earlier analysis [5]. Sprint type activity has been established to recruit the afferent stabilizing firing of muscle, further suggesting an hGH axis and stability firing relationship [6].

The relationship between hGH levels and stabilization was more precisely indicated by McCall, et al. [7], where it was demonstrated that the use of forced mechanical vibration to destabilize the tibialis anterior muscle produces an increase in plasma levels of bio-assayable hGH. Notably McCall observes that levels of bioassayable hGH are not affected by stimulation of the soleous muscle. While McCall postulates that there is an excitatory effect for the production of this hormone in response to the recruitment of type I and IIa muscle spindle afferents through destabilization, the researchers also note that this excitatory activation may not be present in all muscles and may even be inhibitory in some cases.

The identification of a relationship between a form of hGH secretion and the activation of muscle afferents through destabilization of the tibialis anterior raises a question as to whether those results underlie a generic principle such that the application of destabilizing environments to all of the muscles in the body (and thus to all muscle spindle afferents) has a combined effect, excitatory or otherwise on the plasma levels of hGH.

The authors performed a systematic review and meta-analysis to evaluate existing data describing hGH serum level changes when a test subject’s entire body is exposed to a destabilizing environment. Both pre to post observational trials and controlled experiments with a placebo group were considered. Changes in serum hGH postintervention or differences in hGH levels between treatment groups and control groups, as applicable by study type were evaluated. Analysis was performed to determine the impact of whole body muscle destabilization on hGH levels as illustrated by the body of currently published research.

Methods

Literature search

The authors developed a search strategy for identifying pertinent studies available on the MEDLINE, PubMed, Harvard HOLLIS, or EMBASE databases. Studies published through January 1, 2016 that were published in English or available in an English translation were queried using the search terms: “vibration,” “stability,” and “human growth hormone.”

Study selection

Two kinds of randomized trials were selected: First, observational studies where serum hGH was measured before and immediately after the subject experienced a destabilizing intervention. Second, controlled studies where hGH was measured for a test group subjected to destabilizing intervention (and in some cases a concurrent selfstabilized exercise) and for a control group that was not subject to the destabilization based intervention. Data sets were excluded if motorized vibratory method was of imperceptible magnitude, and therefore reflected a stimulus too weak to achieve stabilizing activation of muscle afferents, which is the potential mechanism of action under analysis.

Data abstraction

All three authors independently reviewed the studies for compliance with selection criteria and then abstracted data for the analysis. These data were compared and resolved by repeated review.

Data abstracted

Authors abstracted data on each study including all reported hGH serum concentrations and standard deviations thereof, the number of study participants, the mean age of participants and the standard deviation of that average, the gender of participants, and whether any conflict of interest was disclosed. For included studies all of the above data was available.

Quantitative data synthesis

When evaluating changes in hGH concentration between pre-topost measurements of that metric for observational studies, we considered the results of each study using that change represented as a percentage of the mean pre value. The change was evaluated as a percentage of baseline because hGH concentrations measured prior to the destabilizing intervention varied tremendously between studies, regardless of the age of the participants. This suggested that the sensitivities of the hGH blood-work assays used may not have been consistent across different studies, while presumably being consistent within studies. Likewise, a similar potential exists for other variables impacting the value in certain studies, such as the protocol used in the centrifugal preparation of serum samples implemented in some studies but not described in detail. The PRISMA method of systematic review was followed in this analysis [8].

Results were evaluated for controlled studies using the same percentage type hGH metric, where the difference between mean test values and mean control values in each study was represented by that difference in means as a percentage of the mean control hGH level for the same study.

Pre-to-post observational studies were evaluated separately from controlled studies, and the results are averaged separately. When evaluating average impacts for either set of studies, mean percent changes were weighted based on the number of study participants. 95% Confidence Intervals were calculated from standard deviations using a Z critical value of 1.96.

Because only one study disclosed a conflict of interest, and that study yielded results that were very similar to other studies in its category, no penalty was applied to it in the calculation of average hGH concentration change for that category. That study is, however, designated as subject to conflict of interest in the results section where its results are depicted graphically and numerically alongside all other studies.

Results

Participants in evaluated studies varied widely in age. For pre-topost observational studies participants had a mean age of 35.1 [SD, 13.6]. The youngest of those study populations had a mean age of 17.8 [SD,0.88], and the oldest mean age was 70 [SD, 9.5]. For controlled studies the mean age was 41.6 [SD,17.2]. The youngest and oldest study population mean ages remained 17.8 [SD,0.88] and 70 [SD,9.5], respectively. Women comprised 23% of pre-to-post study population and 18% of controlled study population (Figure 1).

steroids-hormonal-science-Study-Selection

Figure 1: Study Selection Screening.

Study characteristics

Only one study fulfilled all evaluated study criteria/characteristics per Table 1, although all studies fulfilled at least two criteria and the mean number of criteria met by included studies was 4.1 out of 7 possible. Because some studies evaluated were pre-to-post observational, and the quality requirements indicated in Table 1 favor controlled studies, they are not universally satisfied.

Study Were Eligibility Requirements Stated? Was a Placebo Offered? Did Test and Control Group Members have Similar Baseline Characteristics? Were Participants Blinded? Unbiased analysis? Were Clinicians Blinded? Was Destabilization Protocol Clearly Defined using Quantifiable Metrics?
Bosco et al.[9] ● ○ N/A ○ ○ ○ ●
Cardinale et al.[10] ● ● ● ● ● ○ ●
DiLoreto et al.[11] ● ● ● --- ● ○ ●
DiGimiani et al.[12] ● ● ● ● ● ● ●
Elmantazer, et al.[13] ● ○ N/A ○ ● ○ ●
Fricke et al.[14] ● ○ N/A ○ ● ○ ●
Goto et al.[15] ● ○ N/A ○ ● ○ ●
Guinta et al.[16] ● ○ N/A ○ ● ○ ○
Guinta et al.[17] ● ● ● ○ ● ○ ○
Guo-Shing et al.[18] ● ● ● --- ● ○ ○
Iodice et al.[19] ● ● ● --- ● ○ ●
Kvorninget al.[20] ● ● ● --- ● ○ ●
McCall et al. ● ○ N/A ○ ● ○ ●
Rahman et al.[21] ● ● ● --- ● ○ ○
Sartorio et al.[22] ● ● ● ○ ● ○ ●
Seok et al.[23] ● ● ● --- ● ○ ---
Legend: ●=Yes; ○=No; --- =Unclear

Table 1: Study Criteria/Characteristics.

Most studies were small, with mean size of 11 participants at completion. Study retention rates were high, with 98.3% of participants overall following through to completion of the study. No adverse events were reported. Destabilizing environments implemented in the evaluated studies were created using forced mechanical vibration in all cases. Destabilization characteristics varied significantly, with frequencies ranging from 12 Hz (Rahman) to 300 Hz (Iodice) and magnitudes as large as 5 mm (Sartorio) and as small as 1 mm (Fricke).

Quantitative data synthesis

Observational pre/post: All studies report hGH serum values, as this was a prerequisite for study consideration. For the 22 pre-to-post test groups evaluated, every sample indicated an increase in serum growth hormone following the intervention, and showed statistical significance (p<0.05) independently. Intervention characteristic matrices found in Appendix 1 and Appendix 2.

The mean change in hGH level was 647% [95% CI, 541% to 753%] (P=0.00001) for all of the assays combined. Mean change analysis excluded one study that altered its blood sample concentrations via centrifuge (McCall). The least hGH response was seen in Cardinale et al., (mean increase of 64.7%), and the greatest was from Kvorning et al (mean increase of 2800%) (Figure 2).

steroids-hormonal-science-Post-forest

Figure 2: Pre/Post forest plot.

RTCs: For the RCTs, the mean increase in GH was 101% [95% CI, 85.7% to 116%] (P 0.006). Of the 13 RCTs evaluated here, three studies showed increases that were not statistically significant individually, while the remaining 10 studies indicated significant increases. The greatest mean change in serum concentration for any study group was 318% (Kvorning) (Figure 3).

steroids-hormonal-science-RTC-forest

Figure 3: RTC forest plot.

Limitations

Some of the included controlled studies had stability firing type activity as a control intervention (e.g., free-weight squat exercises). The objective of this analysis was to determine the relationship between specific reflexive (Il and Ia afferent) body-stabilizing firing and hGH levels, and since these control data sets may have elicited increases in hGH by this same mechanism, resulting findings are less impactful. Most of the studies included small sample sizes and most studies applied interventions to younger populations.

Safety of the Intervention

No adverse events were documented during any study.

Discussion

It has long been established that exercise causes an acute release of hGH, but the underlying mechanism (or mechanisms) remain unclear. Existing literature review on the physiological processes underlying hGH release during exercise by Godfrey et al. hypothesizes a muscle afferent pituitary axis [24]. For hGH as measured through standard immunoassays Godfrey found that most studies evaluated in the analysis indicate that hGH release occurs following exercise of sufficient intensity, which is consistent with possible muscle afferent neural modulation of the pituitary, but is not sufficient evidence to rule out other exercise related physiological changes as possible signaling mechanisms, such as Catecholamine or lactate release, pH balance changes, or especially Nitric Oxide release. This inability to more narrowly characterize a physiological mechanism in the Godfrey analysis is a result of the conventional exercise protocols that were assayed, because these would be expected to simultaneously induce activity in all of the aforementioned signaling mechanisms. The unique data set considered in Godfrey’s review that avoided this problem, is the McCall, et al. data involving destabilization of individual muscles in situ using forced mechanical vibrations. That study demonstrated significant increases in isoforms of hGH, but only involved the destabilization of individual muscles, effectively isolating a destabilizing environment for study of attenuating afferent muscle activation and hGH.

As the mechanism of interest is the stabilizing firing of muscle afferents, particularly those associated with fast-twitch muscles, this analysis identified studies with destabilizing-environment interventions. Thus while the evaluation was not deliberately construed so as to only involve a single modality, the unique intervention available in current research which met these criteria was that wherein the subject stood on a destabilizing surface. Vibratory destabilization interventions are particularly appropriate as McCall’s research, the inspiration for this analysis, used this modality to elicit the hypothesized reflexive firing of muscle afferents and associated hGH release.

The destabilizing environments applied during the various studies evaluated herein varied tremendously in magnitude and frequency. This contributes greatly to the evidentiary quality of the data in the context of testing the hypothesis that stabilizing muscle afferent activation leads to hGH release, since that premise should be tested with a heterogeneous variety of destabilizing stimuli to understand a general relationship between that kind of stimuli and corresponding serum hGH level release. This also helps avoid falsely generalizing an effect only present with some single specific pattern of vibration. In fact, despite the wide variety of destabilizing protocols used to obtain the evaluated data, across 24 test groups and nearly as many distinct (albeit similar) treatment protocols, three failed to demonstrate significance. However, these three did show a mean increase in hGH levels vs control. Further, the three test cohorts vs control groups that did not reach significance are from small datasets which likely demonstrate a lack of significance only for the lack of a larger sample size.

It is also apparent that pre-to-post delta values for serum hGH levels are much greater than equivalent values comparing test and control groups in the controlled studies. This is consistent with the current understanding of exercise triggered hGH release, possibly due to some controlled studies using alternative exercise as a placebo treatment where the alternative exercise either included a self-stabilization component or was an entirely self-stabilized exercise, both of which would potentially trigger muscle afferents similar but less so than that of the test interventions. Thus the very large changes in serum hGH levels seen in the pre-to-post literature are more telling in the context of our hypothesis.

Variance of increase in hGH were seen with the lowest response at 64.7% (Cardinale), and the greatest at 2800% (Kvorning). The differences in protocol were pronounced as well. The Cardinale protocol included two legs with slight knee flexion for 1-minute bouts. Kvorning applied instability to two subject cohorts that both maintained a two-legged 90-degree knee bend for 30 seconds per bout. One subject cohort used a weighted bar resting stabilized behind the neck, weighing 80% of the subjects 1 rep maximum, and the other alternate cohort held a wooden broomstick handle on their shoulders. While the weighted bar destabilized cohort showed the greatest increase of hGH at 2800%, the near weightless wooden broomstick handle cohort produced an increase of 1865%. Though EMG levels were not measured in either intervention, the afferent activation is known to be greater with a deeper knee bend. The Cardinale protocol placed little demand on muscle afferents, as the positioning of the subjects was slightly greater than that of tonic contraction, and thereby would be expected to elicit a lesser response. The contrast between these two data sets and assay modalities may strengthen indications of a stability firing mechanism as the source of the contrast between the lowest response at 64.7%, and the greatest at 2800%.

Although study characteristics do not score highly on the criteria metrics, that does not detract from the value of the current volume of research into this matter. Specifically, pre-to post literature is not controlled, or blinded, which leads to low scores on our metric even for well-conducted studies with no bias or conflict of interest declared. Only hGH serum levels were evaluated which are a quantifiable biochemical metric measured by immunoassay where results are observed by computer measurement of permeability to electromagnetic radiation. Therefore, selection bias on the part of the researchers seems unlikely. Further, deliberate auto-regulation of hGH by a human as a result of the placebo effect or otherwise has never been demonstrated, so it would not diminish the value of the hypothesized mechanism if it were the case that subjects increase their hGH levels only in presence of a known destabilizing environment.

By combining all the data available there is a stronger indication of a relationship between afferent stability firing and acute hGH increases than was previously understood.

Role of the Funding Sources

The authors were supported by Performance Health Systems LLC, The funding source had no role in the design, collection, or reporting of the data or study, or in the decision to submit the analysis for publication.

Appendix

Study Year Ctrl Baseline GH Post Test GH Delta GH Sample Size Participant Age M/F Bias Notes
Bosco et al. [9] 2000 N 6.2 ± 16.2 ng/ml 28.6 ± 29.6 ng/ml +22.4 ± 45.8 ng/ml 14 25 ± 4.6 14/0 Y  
Cardinal et al. [10] 2008 Y 1.6± .3 µIU/ml 2.7 ± 0.7µIU/ml +1.1 ± 1 µIU/ml 20 70 (66, 85) 9/11 N  
Di Loreto et al. [11] 2004 Y 1.7 ± 0.6µIU/ml 7.4 ± 3.6µIU/ml +5.7 ± 4.2 µIU/ml 10 39 ± 3 10/0 N  
DiGiminani et al. [12] 2014 Y 50 ± 20 nM 390 ± 60 nM +340 ± 80 nM 10 25 ± 0.9 10/0 N  
DiGiminaniet al. [12] 2014 Y 50 ± 20 nM 225 ± 70 nM +175 ± 90 nM 10 25 ± 0.9 10/0 N  
Elmantazer et al. [13] 2012 N 0.07 ± 0.1 ng/ml 0.57 ± 0.1 ng/ml +0.5 ± 0.2 ng/ml 10 33 (29, 49) 10/0 N  
Fricke et al. [14](Male) 2009 N 0.250 ± 0.216ng/ml 1.58 ± 0.51ng/ml +1.33 ± .726 ng/ml 10 32.1 ± 5.8 10/0 N  
Fricke et al. [14] 2009 N 8.807 ± 7.570 ng/ml 15.017 ± 1.879 ng/ml +6.21 ± 9.449 ng/ml 10 32 ± 6.9 0/10 N  
Goto et al. [15] 2005 Y 0.2 ± .001ng/ml 4.6 ± 1.7 ng/ml +4.4 ± 1.701 ng/ml 8 23.4 ± 0.9 8/0 N  
Guinta et al. [16] (Vib) 2012 N 0.4 ± 0.3 ng/ml 5.1 ± 1.9 ng/ml +4.7 ± 2.2 ng/ml 7 22 ± 5 0/7 N  
Guinta et al. [16] 2012 N 0.7 ± 0.9 ng/ml  6.5 ± 3.7 ng/ml +5.8 ± 4.6 ng/ml 7 22 ± 5 0/7 N  
Guinta et al. [17] 2013 Y 2.2 ± 0.4 ng/ml 9.7 ± 2.7 ng/ml +7.5 ± 3.1 ng/ml 6 27.7 ± 1.3 0/6 N  
Guintaet al. [17] 2013 Y 1.3 ± 0.6 ng/ml 18.3 ± 3.0 ng/ml +17 ± 3.6 ng/ml 6 27.7 ± 1.3 0/6 N  
Guo-Shing et al. [18] 2007 Y 3.39 ± 0.91 ng/ml 9.43 ± 2.39 ng/ml +6.04 ± 3.3 ng/ml 8 17.8 ± 0.88 8/0 N  
Iodice et al. [19] 2011 Y 0.1 ± 0.01 ng/ml 0.3 ± 0.05 ng/ml +0.2 ± .06 ng/ml 18 21 ± 1.4 18/0 N  
Kvorninget al. [20] 2006 Y 0.24 ± 0.17 µIU/ml 11.6 ± 3.80 µIU/ml +11.36 ± 3.97 µIU/ml 8 23 ± 0.7 8/0 N  
Kvorning et al. [20] 2006 Y 1.17 ± 0.81 µIU/ml 23 ± 2.3 µIU/ml +21.83 ± 3.11 µIU/ml 8 23 ± 0.6 8/0 N  
McCall et al. 2000 N 1216 ± 148 ng/ml 2362 ± 487 ng/ml +1146 ± 635 ng/ml 10 26.7 ± 1.6 10/0 N *
Rahman et al. [21] 2014 Y 6.4 ± 5.07 ng/ml 11.6 ± 3.80 ng/ml +5.2 ± 8.87 ng/ml 30 62-75 30/0 N  
Sartorio et al. [22] 2010 N 0.34 ± 0.006 ng/ml 4.8 ± 0.5 ng/ml +4.46 ± .506 ng/ml 9 23 ± 2 9/0 N  
Sartorio et al. [22] 2010 N 0.44 ± 0.01 ng/ml 18 ± 5.0 ng/ml +17.56 ± 5.01 ng/ml 9 23 ± 2 9/0 N  
Seok et al. [23] 2007 Y 0.96 ± 0.01 ng/ml 5.55 ± 3.12 ng/ml +4.59 ± 3.13 ng/ml 7 25.4 ±2.2 0/7 N  
*Destabilizing forces applied to one muscle only.GH measured using nonstandard test.

Appendix 1: Pre/Post data table.

Study Year Control GH Test GH Delta GH Sample Size Participant Age M/F P Value Bias Notes
Cardinale et al. [10] 2008 3 ± 0.7μIU/ml 2.7 ± 0.7μIU/ml  -0.3 ± 1.4 μIU/ml 20 70 (66, 85) 9/11 0.4 N *
Di Loreto et al. [11] 2004 5.2 ± 2.5μIU/ml 7.4 ± 3.6μIU/ml +2.2 ± 6.1 μIU/ml 10 39 ± 3 10/0 0.216 N  
DiGiminani et al. [12] 2014 130 ± 60 nM 390 ± 60nM +260 ± 120nM 10 25 ± 0.9 10/0 0.003 N  
DiGiminani et al. [12] 2014 130 ± 60 nM 225 ± 70nM +95 ± 130nM 10 25 ± 0.9 10/0 0.003 N  
Goto et al. [15] 2005 2.8 ± 1.2 ng/ml 4.6 ± 1.7 ng/ml +1.8 ± 2.4 ng/ml 8 23.4 ± 0.9 8/0 0.453 N  
Guinta et al. [17] 2013 8.4 ± 2.3 ng/ml 9.7 ± 2.7 ng/ml +1.3 ± 5 ng/ml 6 27.7 ± 1.3 0/6 0.05 N  
Guinta et al. [17] 2013 8.4 ± 2.3 ng/ml 18.3 ± 3.0 ng/ml +9.9 ± 5.3 ng/ml 6 27.7 ± 1.3 0/6 0.05 N  
Guo-Shing et al. [18] 2007 8.15 ± 1.62 ng/ml 9.43 ± 2.39 ng/ml +1.28 ± 4 ng/ml 8 17.8 ± 0.88 16/0 0.05 N  
Iodice et al. [19] 2011 0.1 ± 0.05 ng/ml 0.3 ± 0.05 ng/ml +0.2 ± 0.1 ng/ml 18 21 ± 1.4 18/0 0.05 N  
Kvorning et al. [20] (Vib) 2006 5.5 ± 2 μIU/ml 11.6 ± 3.80 μIU/ml +6.1 ± 5.8 μIU/ml 9 23 ± 0.7 28/0 0.05 N  
Kvorning et al. [20] 2006 5.5 ± 2 μIU/ml 23 ± 2.3 μIU/ml +17.5 ± 4.3 μIU/ml 9/10 23 ± 0.6 28/0 0.05 N  
Rahman et al. [21] 2014 7.0 ± 7.6 ng/ml 11.6 ± 3.80 ng/ml +4.6 ± 11.4 ng/ml 30 62-75 60/0 0.05 N  
Seok et al. [23] 2007 1.83 ± 2.24 ng/ml 5.55 ± 3.12 ng/ml +3.72 ± 5.36 ng/ml 7 24.9 ± 4.1 0/14 0.05 N  
*Control Group had an exercise protocol that may have caused stabilization firing of muscle afferent neurons.

Appendix 2: RTC data table.

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