Stem Cells and Regenerative Medicine
Received Date: Nov 02, 2016 / Accepted Date: Nov 08, 2016 / Published Date: May 31, 2018
First described back in 2002 in the manuscript Molecular Biology of the Cell, UCLA researchers introduced a new innovative adult stem cell population found in adipose tissue, known as adipose-derived stem cells (ADSC). Ever since, ADSCs have become the most prominent type of adult stem cell used in the field. No longer is adipose tissue seen as only a mass of cells involved in fat storage, rather it is seen as a sophisticated ensemble of cellular components with highly specialized and complex functions such as stromal-vascular fraction. Adipose tissue is a source of freshly isolated, heterogeneous stromal vascular fraction cells, and relatively homogeneous adipose stromal stem cells. Both populations display regenerative faculty in soft and hard tissue repair, ischemic injury and autoimmune diseases . While they are known to accomplish both the release of paracrine factors as well as direct lineage differentiation, present-day evidence favors the former paracrine mechanism as its primary method of action.
Due to its abundance, accessibility and reliability, adipose tissue is a great source of multipotent adult stem cells and thus, used by many researchers for tissue engineering purposes. Several scientific studies validate the potential of adipose adult stem cells in regenerative medicine [2-4].
It has become apparent that to effectively translate ADSCs into clinical practice requires relying on technologies that can simplify and maximize the efficacy of the ADSCs. The most optimal methods in translational technology that minimize complications include: closedsystem operations, biosensors and real-time monitoring, biomimetics and rapid manufacturing. These methods greatly reduce the required resources for in vitro cell handling and effectively minimize human error. For example, through closed-system isolation devices, clinicians can both isolate a patient’s cells and re-administer the cells back into the patient in one surgery. The successful isolation of stromal vascular fraction (SVF) from adipose tissue with these devices has already been seen in a number of clinical trials and treatments for tissue repair. Although much advancement in ADSC research has been made in the last few years, more innovation in successful ADSC translation is needed [4-7].
Translational research on ADSC could enable clinicians to treat patients with ADSC therapies for an array of conditions ranging from tissue engineering to immunomodulatory applications. As ADSCs work their way into clinical practice, it is essential that researchers, physicians, the industry, and regulatory agencies work together to bring promising ADSC therapies to patients in a safe and effective manner.
Considering that chronic non-communicable diseases are the biggest challenge of the 21st century, I have no doubt that this decade will be renowned for its advancements in regenerative medicine and adipose-derived adult stem cell research .
- Brunt KR, Weisel RD, Li RK (2012) Stem cells and regenerative medicine - future perspectives. Can J Physiol Pharmacol 90: 327-335. [PubMed]
- Chimenti I, Smith RR, Li TS, Gerstenblith G, Messina E, et al. (2010) Relative roles of direct regeneration versus paracrine effects of human cardiosphere-derived cells transplanted into infarcted mice. Circ Res 106: 971-98. [PubMed]
- Hansson EM, Lindsay ME, Chien KR (2009) Regeneration next: Toward heart stem cell therapeutics. Cell Stem Cell 5: 364-377.
- Sampogna G, Guraya SY, Forgione A (2015) Regenerative medicine: Historical roots and potential strategies in modern medicine. JMAU 3: 101-107.
- Comella K, Parcero J, Bansal H, Perez J, Lopez J, et al. (2016) Effects of the intramyocardial implantation of stromal vascular fraction in patients with chronic ischemic cardiomyopathy. J Transl Med 14: 158. [PubMed]
- New SE, Ibrahim A, Guasti L, Zucchelli E, Birchall M, et al. (2016) Towards reconstruction of epithelialized cartilages from autologous adipose tissue-derived stem cells. J Tissue Eng Regen Med 11: 3078-3089. [PubMed]
- Kim JH, Joo HJ, Kim M, Choi SC, Lee JI, et al. (2016) Transplantation of adipose-derived stem cell sheet attenuates adverse cardiac remodeling in acute myocardial infarction. Tissue Eng 23: 1-11. [PubMed]
- Frese L, Dijkman PE, Hoerstrup SP (2016) Adipose tissue-derived stem cells in regenerative medicine. Transfus Med Hemother 43: 268-274. [PubMed]
Copyright: © 2018 Garber MG. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Select your language of interest to view the total content in your interested language
Share This Article
11th International Conference on Tissue Engineering & Regenerative Medicine October 18-20, 2018 Rome, Italy
October 18-20, 2018 Rome, Italy
24th Biotechnology Congress: Research & Innovations October 24-25, 2018 Boston, USA
October 24-25, 2018 Boston, USA
International Conference on Human Genome Meeting October 25-26, 2018 Istanbul, Turkey
October 25-26, 2018 Istanbul, Turkey
International Congress & Expo on Genomics and Bioinformatics November 2-3, 2018 Columbus, Ohio, USA
November 2-3, 2018 Columbus, USA
12th International Conference & Exhibition on Tissue Preservation and Biobanking November 9-10, 2018 Atlanta, Georgia, USA
November 9-10, 2018 Atlanta, USA
2nd Annual Summit on Cell Therapy and Stem Cell Research November 9-10, 2018 Atlanta, Georgia, USA
November 9-10, 2018 Atlanta, USA
- Total views: 460
- [From(publication date): 0-2018 - Oct 20, 2018]
- Breakdown by view type
- HTML page views: 417
- PDF downloads: 43