alexa Superscan Imaging on Ga-68 PSMA PET/CT in Prostate Cancer Patient | Open Access Journals
ISSN: 2155-9619
Journal of Nuclear Medicine & Radiation Therapy
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Superscan Imaging on Ga-68 PSMA PET/CT in Prostate Cancer Patient

Sait Sager*, Elife Akgun, Onur Erdem Sahin, Burak Akgun and Kerim Sonmezoglu

Department of Nuclear Medicine, Istanbul University Cerrahpasa Medical Faculty, Cerrahpasa, Fatih, Istanbul, Turkey

*Corresponding Author:
Sait Sager
Department of Nuclear Medicine
Istanbul University, Cerrahpasa Medical Faculty
Cerrahpasa, Fatih, Istanbul, Turkey
Tel: +90 212 414 3000, 9021241422984
Fax: +90 212 530 8055
E-mail: [email protected]

Received date: November 13, 2016; Accepted date: December 03, 2016; Published date: December 06, 2016

Citation: Sager S, Akgün E, Sahin OE, Akgün B, Sönmezoglu K (2017) Superscan Imaging on Ga-68 PSMA PET/CT in Prostate Cancer Patient. J Nucl Med Radiat Ther 8: 320. doi:10.4172/2155-9619.1000320

Copyright: © 2017 Sager S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Abstract

Prostate cancer (PCa) is the most frequent tumor in men worldwide. PCa bone metastasis is mainly osteosclerotic, and is caused by a relative excess of osteoblast activity. A superscan on Tc-99m bone scintigraphy is described in multiple skeletal metastatic disease. Prostate-specific membrane antigen (PSMA) is a cell surface protein with high expression in prostate carcinoma cells. Ga-68 labelled PSMA imaging is used for staging and to evaluate the most appropriate therapy.

Keywords

Prostate cancer; Ga-68 PSMA; Superscan

Case Report

Prostate cancer (PCa) is the most frequent tumor in men worldwide and prostate cancer most often spreads to bone, commonly leading to bone pain [1]. PCa bone metastasis is mainly osteosclerotic, and is caused by a relative excess of osteoblast activity. A superscan on Tc-99m bone scintigraphy is described in multipl skeletal metastatic disease [2].

Prostate-specific membrane antigen (PSMA) is a cell surface protein with high expression in prostate carcinoma cells. Ga-68 labelled PSMA imaging is used for staging and to evaluate the most appropriate therapy [3]. We want to share Ga-68 PSMA PET/CT imaging of a 67- year-old prostate cancer patient. He had a radical prostatectomy after diagnosed PCa with biopsy. His pathology reported as adenocarcinoma with gleason score 4+3=7. Ga-68 PSMA imaging demonstrated extensive and intence skeletal uptake in the axial and appendicular skeleton which is called superscan imaging (Figure 1).

nuclear-medicine-radiation-therapy-intense-skeletal

Figure 1: Superscan showing extensive and intense skeletal uptake in the axial and appendicular skeleton.

Superscan was also described in F-18 FDG PET/CT imaging in extensive metastatic cancer [4]. Vertex to middle femur imaging was performed 60 min after injection of 4 mci Ga-68 PSMA when current total PSA value was 120.06 ng/ml. There is no regional recurrence or lymph node metastasis but multiple sclerotic and lytic lesions with extensive and diffuse uptake at skeleton system (Figure 2).

nuclear-medicine-radiation-therapy-Axial-pelvis

Figure 2: Axial pelvis PET, CT and Fusion images.

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