alexa The Effect of Beams' Orientations on the Intensity-Modulated Radiation Therapy Plan Quality | Open Access Journals
ISSN: 2155-9619
Journal of Nuclear Medicine & Radiation Therapy
Like us on:
Make the best use of Scientific Research and information from our 700+ peer reviewed, Open Access Journals that operates with the help of 50,000+ Editorial Board Members and esteemed reviewers and 1000+ Scientific associations in Medical, Clinical, Pharmaceutical, Engineering, Technology and Management Fields.
Meet Inspiring Speakers and Experts at our 3000+ Global Conferenceseries Events with over 600+ Conferences, 1200+ Symposiums and 1200+ Workshops on
Medical, Pharma, Engineering, Science, Technology and Business

The Effect of Beams' Orientations on the Intensity-Modulated Radiation Therapy Plan Quality

Ehab M Attalla* and Ismail Eldesoky

Children’s Cancer Hospital, National Cancer Institute, Cairo University, Cairo, Egypt

*Corresponding Author:
Ehab M Attalla
Children’s Cancer Hospital
Cancer Institute
Cairo University
Cairo, Egypt
Tel: +201005373359
E-mail: [email protected]

Received date: January 16, 2017; Accepted date: January 20, 2017; Published date: January 23, 2017

Citation: Attalla EM, Eldesoky I (2017) The Effect of Beams' Orientations on the Intensity-Modulated Radiation Therapy Plan Quality. J Nucl Med Radiat Ther 8:324. doi:10.4172/2155-9619.1000324

Copyright: © 2017 Attalla EM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Visit for more related articles at Journal of Nuclear Medicine & Radiation Therapy

Abstract

Purpose: The work aims at studying forty Intensity-modulated radiation therapy (IMRT) plans designed using KonRad system and evaluating each of them under different conditions to study the effect of beams' orientations on the plan quality.
Methods: Clinical step-and-shoot IMRT treatment plans were designed for twenty patients, suffering from different types of non-CNS solid tumors, to be delivery on a Siemens Oncor accelerator with multi-leaf collimators MLCs (82 leaf). To ensure that the similarity or difference between the plans was due to effect of beams' orientations, the same optimization constraints were applied for each plan and all other parameters were kept constant.
Results: The analysis of performance was based on isodose distributions, Dose Volume Histograms (DVHs) for Planning Target Volume (PTV), the relevant Organs at Risk (OARs) as well as several physical indices like mean dose (Dmean), maximum dose (Dmax), 95% dose (D95), integral dose, volume of tumor receiving 2 Gy and 5 Gy, total number of segments and monitor units (MUs). Homogeneity index and conformation number were two other evaluation parameters that were considered in this study.
Conclusion: All coplanar CP and non-coplanar NC techniques result in clinically acceptable plans, with comparable target doses and dose to critical organs within prescribed dose constraints. For different organs at risk, the coplanar IMRT, the greatest advantage of non-coplanar IMRT was the marked reduction of general trend was that non-coplanar plans achieved the lowest values, while coplanar plans showed the highest. Significant differences (P<0.05) exist only between the homogeneity index HI (1.092 and 1.088) and Monitor Unit MU (357.79 and 341.80) of CP and NC plans respectively. Compared with the integral dose (p=0.007).

Keywords

Beams' orientations; Intensity-modulated radiation therapy; Dose distribution; KonRad

Introduction

Radiation efficiency and treatment-plan quality are closely tied to beam angle arrangements and the number of beams used. Research into computer optimization of beam-angle selection has not proved to be clinically useful because of the large angular search space and the dependence on a specific clinical situation [1].

Wang et al. [2] studied the effectiveness of noncoplanar beam configurations and the benefit of plans using few but optimally placed beams and treatment plans optimized using the parallelized multipleresolution beam angle optimization (PMBAO) approach were at least equivalent to, and overall better than, the plans using common equally spaced coplanar beams. The observation that coplanar techniques irradiate OARs to adequately treat adjacent PTV led to the hypothesis that techniques that involve noncoplanar beam arrangements may decrease doses to the critical structures. While non-coplanar IMRT plan usually takes longer treatment planning time and it requires complex patient setup and treatment [3].

Raymond et al. [4] compared dosimetric and radiobiological parameters of treatment plans using coplanar and noncoplanar beam arrangements in patients with fronto-temporal high-grade glioma generated for IMRT or volumetric-modulated arc therapy (VMAT). They concluded that technique selection should be individualized, based on patient-specific clinical and dosimetric parameters. Chang et al. [5] examined the utility of noncoplanar beam angles in IMRT for the management of 16 pancreatic cancer patients. The use of NCP beam angles was preferred only in patients with risk factors for treatment-related kidney dysfunction. The purpose of this study was to compare dosimetric parameters of treatment plans using coplanar and noncoplanar beam arrangements in patients with different selected cases generated for intensity-modulated radiotherapy (IMRT).

Materials

This is a retrospective study Case selection was limited to patients in whom the planning target volume (PTV) overlapped or was located within 3 mm of one of OARs. Twenty patients were enrolled in the retrospective study Table 1. All patients were immobilized in supine position with a customized cushion and thermoplastic masks followed by computed tomography (CT) scanning. The CT slices were acquired every 2 mm; The CT images were then transferred to the TPS via local area network. The photon beam energy for all plans was 6 MV delivered from Siemens linac equipped with 41 pair-leaf MLC. A consensus set of structures was delineated according to department’s clinical protocol, which was similar to the guideline of RTOG, by radiation oncologist for the target, OARs and treatment volumes. The following organs at risk were contoured and included in the analysis: Brain, Brainstem, optic chiasm, RT Cochlea, LT Cochlea, both eyes and lenses.

Diagnosis Prescribed dose (Gy) PTV Volume (CC) Patient Volume (CC)
Ependymoma 54 162 2569
Ependymoma 59.4 254 4371
Ependymoma 54 186 2171
Ependymoma (TB) 59.4 226 2537
PF Eependymoma 54 189 10089
Meningioma 60 759 3867
Astrocytoma 59.4 112 3112
High Grade Glioma 54 189 2821
Base of Skull Chadama 64.8 15 4143
Craniopharyngioma 54 43 4311
Craniopharyngioma 54 64 3176
Craniopharyngioma 54 27 3503
Craniopharyngioma 54 65 2988
Craniopharyngioma 54 162 4661
Retinoblastoma 41.4 30 1314
Retinoblastoma 41.4 42 2064
lt eye 45 29 2795
lt nasal 50.4 87 2297
NPH 60 108 4507
ltingyuinal 59.4 534 10729

Table 1: The Diagnosis, prescription dose, PTV Volume and Patient Volume for the cases used to study the effect of beam orientation on the quality of IMRT plans.

Treatment protocol and plan evaluation

Both coplanar and no coplanar plans were generated for each of the selected cases. Planning was performed by an experienced dosimetrist. Optimization was performed on the study inverse planning system konrad using the Pencil beam dose-calculation algorithm [6]. The planning goal was to have the minimum volume of the PTV covered by the 95% isodose line was 95%. The maximum dose permitted within the PTV was 110%.

Planning commenced with conventional coplanar IMRT using approximately equally-spaced entrance and exit gantry angles. These plans consisted of 9 fields for midline PTVs and 7 fields for more lateral volumes. Fields were applied to the patients with angles 0°, 40°, 80°, 120°, 160°, 200°, 240°, 280°, and 320° for Coplanar IMRT plans while Noncoplanar IMRT plans consist of 7 beams in the same plane and two in different plane usually 30, 330 or 90 with couch angle 270. Couch rotations were limited to one or two angles. In addition, to limit the irradiation by noncoplanar beams of normal tissue located superiorly and inferiorly outside the PTV, we contoured blocking structures at the entry point of the two noncoplanar beams, outside the superior and inferior borders of the PTV. Each plan was evaluated with respect to isodose distributions and dose-volume histograms (DVHs), which were calculated for all the delineated volumes in the two different treatment plans. Additional dosimetric parameters related to the doses received by the PTV included mean, maximum PTV doses and OARs were compared quantitatively. It also included homogeneity index and conformity index as defined by Riet et al. [7] where CN=TVRI/ TV*TVRI/VRI; CN=Conformation Number, TVRI=Target Volume covered by the Reference Isodose, TV=Target Volume and VRI=volume of the reference isodose.

According to the International Commission on Radiation Units and measurements ICRU the reference isodose is 95%. Homogeneity index HI was defined as the difference between the doses covering 5% and 95% of the PTV. The equation is as follows: HI=D5%/D95%. A greater value of HI indicates a greater degree of dose heterogeneity in the PTV. For the PTV, the parameters recommended in ICRU Report No. 83 were adopted; these were D98% (dose delivered to 98% of the volume of the PTV), D2% (dose delivered to 2% of the volume of the PTV), mean dose and dose standard deviation. The different plans were compared using mean statistics. The differences between means were tested for significance using a two-tailed paired Student’s t-test. The null hypothesis was that there was no difference between the coplanar IMRT technique and the non-coplanar IMRT treatment techniques. Statistical significance was set at P<0.05.

Results and Discussion

Conformity and homogeneity of the target

Figure 1 shows the DVH's and the dose distributions for the coplanar IMRT technique (CP) and the non-coplanar IMRT technique (NC) for some of the investigated cases. DVH's for planning target volumes (PTVs) and the dose delivered to OARs are analyzed. The target coverage parameters are given in Table 2.

Parameter Dmax(Gy) Dmean(Gy) D95%(%) D98%(%)
CP NC CP NC CP NC CP NC
Mean±SD 59.0 ±7.1 58.6 ±6.5 54.5 ±6.2 54.5 ±6.2 95.6 ±1.2 95.5 ±1.5 93.4 ±1.8 93.1 ±2.5
P-Value 0.09 0.58 0.68 0.47
Parameter D5% (%) V95% (%) V107% (%)  
CP NC CP NC CP NC
Mean±SD 104.2 ±0.9 104.3 ±1.4 96.5 ±1.4 96.2 ±1.7 1.0 ±1.2 1.1 ±1.9
P-Value 0.87 0.23 0.88
*P-values<0.05 are presented in bold numbers.

Table 2: Dmax (Gy), Dmean (Gy), D95% (%), D98% (%), D5% (%), V95%(%)and V107%(%) for PTVs in the non-coplanar (NC) IMRT and coplanar (CP)IMRT plans, where Dmax: maximum dose to organ, Dmean: mean dose to organ, Dn%: the percentage dose received by the n% volume of the target volume, Vn% : the percentage volume irradiated by n% of the prescribed dose.

nuclear-medicine-radiation-therapy-coplanar-IMRT-technique

Figure 1: The dose distribution and DVH's for the coplanar IMRT technique and the non-coplanar IMRT technique for retinoblastoma case.

The two techniques result in comparable Dmean, Dmax, D98%, D95%, D5%, V95% and V107% for PTV coverage. The non-coplanar IMRT and coplanar IMRT plans are similar (p>0.05). Among the homogeneity index (HI), conformation number (CN), monitor units (MU) and number of segments parameters (Table 3), significant differences (P<0.05) exist only between the HI (1.092 and 1.088) and MU (357.79 and 341.80) of CP and NC plans respectively.

Parameter HI CN MU Segments
CP NC CP NC CP NC CP NC
Mean±SD 1.09 ±0.02 1.1 ±0.02 0.68 ±0.10 0.67 ±0.10 357.8 ±84.9 341.8 ±77.2 57.7 ±21.4 55.8 ±23.2
P-Value 0.03 0.14 0.02 0.14
*P-values<0.05 are presented in bold numbers

Table 3: The homogeneity index (HI), conformation number (CN), monitor units (MU) and number of segments in both of the coplanar (CP) and non-coplanar (NC) plans.

Dose sparing of the OARs

Table 4 presents a number of DVH parameters calculated for CP and NC plans of different OARs. The only significant (P<0.05) differences between CP and NC plans are reported for the Dmean (Gy) parameter of both eyes, where the NC plans (10.54 and 9.35) are always better than CP plans (12.66 and 11.97) for RT and LT eyes respectively.

OARs DVH parameter CP NC P-value
Brain V5Gy (%) 73.1±20.6 69.5±13.9 0.21
V10Gy (%) 60.2 ± 23.9 60.0± 16.7 0.96
V15Gy (%) 49.1 ± 23.1 50.3±20.1 0.12
LT Cochlea Dmean (Gy) 25.5 ± 11.0 25.0 ± 10.6 0.19
RT Cochlea Dmean (Gy) 23.1 ±10.7 23.0 ± 9.3 0.29
Brain stem Max 1cm3 49.4 ± 10.9 49.3 ± 11.6 0.92
Optic chaism Max (Gy) 30.5 ± 13.0 29.9 ± 14.5 0.52
Rt eye Dmean (Gy) 12.7 ± 6.4 10.5 ± 6.3 0.0001
Lt eye Dmean (Gy) 11.9 ± 5.7 9.4 ± 6.4 0.001
Rt lens Dmean (Gy) 6.5 ± 2.8 5.1 ± 2.9 0.14
Lt lens Dmean (Gy) 5.6 ± 2.1 4.3 ± 2.9 0.23
*P-values<0.05 are presented in bold numbers.

Table 4: The dose–volume parameters for different OARs for coplanar (CP) and non-coplanar (NC) plans, where Dmean: mean dose to organ, VnGy: the percentage volume irradiated by n Gy or more of a certain structure.

Integral dose (ID) and dose to normal tissue

Table 5 shows that for the integral dose, D1% (Gy), D2% (Gy), and D5% (Gy), the CP plans significantly (p<0.05) reduce the dose to normal tissue (41.65, 55.50, 53.19 and 42.72 respectively) compared to NC plans (43.70, 55.98, 54.85 and 48.95 respectively).

Parameter Integral Dose D1%(Gy) D2%(Gy)
  CP NC CP NC CP NC
Mean 41.7 43.7 55.5 55.9 53.2 54.9
SD 30.7 31 6.4 6.4 7.1 6.5
P-value 0.007   0.009   0.022  
Parameter D5%(Gy) V2Gy(%) V5Gy(%)
  CP NC CP NC CP NC
Mean 42.7 48.9 72.1 74.9 58.4 61.5
SD 14.6 10.6 17.1 15.5 19.1 14.2
P- value 0.001   0.4   0.31  
*P-values<0.05 are presented in bold numbers.    

Table 5: Integral dose and low dose distribution in healthy tissue, where Dn%: the dose received by the n% volume of the organ volume, VnGy: the percentage volume irradiated by n Gy or more of a healthy tissue.

Non-coplanar IMRT does have some disadvantages. One should bear in mind the remark reported by Kan et al. [8] who stated that the use of non-coplanar beams might increase the peripheral dose. Moreover, the non-coplanar beam setup requires changing the couch angle, which increases the overall treatment time substantially. This can be compensated by the significant reduction in the combination of the number of MUs and the number of segments which results in shorter delivery times. Since cancer patients may have difficulties lying on the treatment couch for long periods of time during the radiation delivery, shortening the IMRT treatment time decreases the risk that patients involuntarily move during radiation therapy. It also minimizes the risk of decreased tumor cell killing potentially associated with delivery times in the range of 15 min to 45 min [9,10].

Conclusion

The hypothesis of the study, focus on the importance of the beam orientation since such selected beam orientations can reduce overall time, making the IMRT more practically in the clinical implementation. In case of the Non-Coplanar beams; orientations provide an additional degree of freedom for IMRT treatment optimization and facilitate to improve the quality for some complicated plans.

Also, the study provides a realistic methodology to research the characteristics of the IMRT dose distributions as a function of beam angle and to design practical filtering beam angle optimization strategies for IMRT planning. Although a slight impact is shown on some of the OARs, both non-coplanar and coplanar techniques achieved comparable target coverage. The main advantage of coplanar IMRT is the marked reduction of the integral dose. Also the overall treatment time is reduced because the couch angle has not to be changed.

References

Select your language of interest to view the total content in your interested language
Post your comment

Share This Article

Recommended Conferences

Article Usage

  • Total views: 581
  • [From(publication date):
    January-2017 - Jun 25, 2017]
  • Breakdown by view type
  • HTML page views : 533
  • PDF downloads :48
 

Post your comment

captcha   Reload  Can't read the image? click here to refresh

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords