The Effect of Nanosilver Products in Prevention and Management of Diabetic Foot Ulcer
Received Date: Sep 01, 2013 / Accepted Date: Sep 02, 2013 / Published Date: Sep 06, 2013
It is estimated that the lifetime risk of foot ulcer among diabetic patients is about 25% . The prognosis of different types of foot infections in diabetic patients is unknown. On the other hand, it would be mentioned that in 25-50% diabetics, diabetic foot infection is one of the causes of lower limb amputation [2-7]. Accordingly this complication is related to the morbidity and mortality in diabetic patients . Therefore novel prevention and treatment strategies could be implemented in diabetes care plan.
In this regard, Nanotechnology with good antimicrobial properties against bacteria, viruses and other eukaryotic micro-organisms could be an emerging science which has the growing use of new materials at nanoscale stages [9,10]. Currently nanosilver products are used more popularity in clothing, food containers, wound dressings, ointments, implant coatings, and many other substances .
There are different studies which evaluating the effect of nanosilver on the variety microorganisms grown. Morones et al. showed that antibacterial activity of silver nanoparticles against four types of gram negative bacteria, E. coli, V. cholera, P. aeruginosa and S. typhus. This study concluded that silver nanoparticles attach to the cell membrane and release silver ions . Similarity Sondi and Salopek suggested the antimicrobial activity of silver nanoparticles against E. coli, a gramnegative bacterium . By the way Panacek et al. emphasize on high antimicrobial and bactericidal activity of silver nanoparticles against gram-positive and gram-negative bacteria. They were methicillin resistant S. aureus .
According to the different studies in this field, it could be concluded that silver nanoparticles by means of the unique chemical and physical properties could be used as a useful option for the available antibacterial agents for diabetic foot infection. In view of the various functions of wound dressings, medical device coatings, silver nanoparticles impregnated textile fabrics, silver nanoparticles could be applied to prevent and treat diabetic foot ulcers.
- Boulton AJ, Vileikyte L, Ragnarson-Tennvall G, Apelqvist J (2005) The global burden of diabetic foot disease. Lancet 366: 1719-1724.
- Apelqvist J, Castenfors J, Larsson J, Stenström A, Agardh CD (1989) Wound classification is more important than site of ulceration in the outcome of diabetic foot ulcers. Diabet Med 6: 526-530.
- Fylling CP, Knighton DR (1989)Amputation in the diabetic population: incidence, causes, cost, treatment and prevention. J Enterostom Ther 16: 247-255.
- Pecoraro RE, Reiber GE, Burgess EM (1990) Pathways to diabetic limb amputation. Basis for prevention Diabetes Care 13: 513-521.
- Larsson J, Agardh CD, Apelqvist J, Stenström A (1994) Local signs and symptoms in relation to final amputation level in diabetic patients. A prospective study of 187 patients with foot ulcers. Acta Orthop Scand 65: 387-393.
- Larsson J, Apelqvist J, Agardh CD, Stenström A (1995) Decreasing incidence of major amputations in diabetic patients-a consequence of a multidisciplinary foot care team approach? Diabetic Med 12: 770-7766.
- Eneroth M, Apelqvist J, Stenström A (1997) Clinical characteristics and outcome in 223 diabetic patients with deep foot infections. Foot Ankle Int 18: 716-722.
- Caputo GM, Cavanagh PR, Ulbrecht JS, Gibbons GW, Karchmer AW (1994) Assessment and management of foot disease in patients with diabetes. N Engl J Med 331: 854-860.
- Matthew AA, Cameron WE, Colin LR (2006) Green chemistry and the health implications of nanoparticles. Green Chem 8: 417-432.
- Ping Gong, Huimin Li, Xiaoxiao He, Kemin Wang, Jianbing Hu, et al. Preparation and antibacterial activity of [email protected] nanoparticles. Nanotechnology 18: 604-611.
- Dunn K, Edwards-Jones V (2004) The role of Acticoat with nanocrystalline silver in the management of burns. Burns 30: S1-S9.
- Morones JR, Elechiguerra JL, Camacho A, Holt K, Kouri JB, et al. (2005) The bactericidal effect of silver nanoparticles. Nanotechnology 16: 2346-2353.
- Sondi I, Salopek-Sondi B (2007) Silver nanoparticles as antimicrobial agent: a case study on E. coli as a model for gram-negative bacteria. J Colloid Interface Sci 275: 177-182.
- Panacek A, Kvítek L, Prucek R, Kolar M, Vecerova R, et al. (2006) Silver colloid nanoparticles: synthesis, characterization, and their antibacterial activity. J Phys Chem 110: 16248-16253.
Citation: Mohajeri-Tehrani MR and Aalaa M (2013) The Effect of Nanosilver Products in Prevention and Management of Diabetic Foot Ulcer. J Biomol Res Ther 2: e117. Doi: 10.4172/2167-7956.1000e117
Copyright: © 2013 Mohajeri-Tehrani MR, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Select your language of interest to view the total content in your interested language
Share This Article
- Total views: 12451
- [From(publication date): 12-2013 - Oct 21, 2018]
- Breakdown by view type
- HTML page views: 8643
- PDF downloads: 3808