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The Effect of Trigonella Foenum Graceum L. (Fenugreek) on Metabolic Syndrome: An Accidental Finding
ISSN: 2167-0943

Journal of Metabolic Syndrome
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The Effect of Trigonella Foenum Graceum L. (Fenugreek) on Metabolic Syndrome: An Accidental Finding

Laleh Oveidzadeh*, Majid Emtiazy, Minoo Habibi, Zahra Jafari and Mohammad Kamalinejad
Shahid Sadoughi University of Medical Sciences and Health Services, Iran
*Corresponding Author: Laleh Oveidzadeh, Shahid Sadoughi University of Medical Sciences and Health Services, Ardakan, Yazd, Iran, Tel: +989166522543, Email: [email protected]

Received Date: Oct 07, 2017 / Accepted Date: Oct 16, 2017 / Published Date: Oct 25, 2017


Keywords: Glucose; Metabolic; Trigonella foenum graceum ; Hypoglycemic effect; Treatment


The combination of a few conditions such as obesity, glucose intolerance, hyperlipidemia, and hypertension are called metabolic syndrome. Metabolic syndrome is strongly associated with diabetes mellitus and cardiovascular events [1,2]. The prevalence of metabolic syndrome is rapidly increasing these days.

Therefore, there is an urgent need for a drug or adjuvant therapy that could treat all conditions of metabolic disorders.

In an unpublished study, we investigated the effect of aqueous extract of Trigonella foenum graceum (Fenugreek)seeds on mild asthma. This was a triple blind trial including a placebo. The trial included participants aged 20 years to 70 years, who did not have any acute diseases. The daily dose of fenugreek was 10 g and the study lasted 4 weeks (Table 1).

  Before treatment St. error After treatment St. error P. value
FBS 95.25 1.5 95.33 2.8 0.97
Chol 179.25 4.6 173.75 5.6 0.05
TG 139.33 19.8 120.58 14.6 0.03
SGOT 26.33 2.1 21 0.88 0.02
SGPT 37.75 4.7 24.9 1.9 0.03

Table 1: The result before and after treatment with fenugreek syrup.

Based on the information in adverse events related to fenugreek reported in laboratory and animal studies, liver function tests, thyroid function test, lipid profiling, and biochemical test were performed before and after treatment; the participants were closely monitored. Although all test results were in normal range before treatment, significant decreases in cholesterol (179.2 to 173.7; P=0.05), triglyceride (139.3 to 120.5; P=0.003), and liver function test (SGOT: 26.3 to 21; P=0.02 and SGPT: 37.7 to 24.9; P=0.003) results were observed after treatment.

Despite the hypoglycemic effect of fenugreek mentioned in several studies [3], we did not observe any significant decrease in blood sugar level (95.2 to 95.3; P=0.9). This may because we used honey as the base for administration of the fenugreek extract. In addition, we used a low dose of fenugreek; nevertheless, studies have reported that 25 g of powdered seeds were enough to lower blood sugar levels [3].

Many studies have suggested the hepatoprotective role for fenugreek [4-7]. This could be due to the antioxidant activity of seeds, in addition to their anti-inflammatory and anti- fibrotic properties.

Studies have also reported the lipid-lowering role of fenugreek [8]. Fenugreek seeds contain active ingredients such as flavonoids, fiber, amino acids, steroid sapogenin, and ext that show lipid-lowering properties.

Flavonoids have antioxidant and anti-inflammatory properties. One of the active steroid sapogenin present in fenugreek is diosgenin; studies have determined its glycemia reduction [9-11] and hepatoprotective roles in animal models. In addition, a few studies have reported the endothelial function of diosgenin, suggesting the role of fenugreek in regulating cardiovascular effects [12,13].

Another active ingredient in fenugreek seed is 4-oh-Ile, a plant amino acid. In streptozotocin-induced diabetic rats, consumption of 4- oh-Ile 8 weeks showed improvement in glycemic control and liver marker function [14].

Fenugreek seeds are rich in fiber (32% insoluble and13% soluble) [15]. It has been reported that fenugreek fiber can inhibit hydrolyzing enzymes in the gastrointestinal system [16,17]. This resulted in a decrease in postprandial blood sugar and lipid profile. Together, the findings of these studies show the importance of an ancient remedy in treating today’s most concerning syndrome. Further human studies and large randomized control trials are recommended to determine the effectiveness of fenugreek.


Citation: Oveidzadeh L, Emtiazy M, Habibi M, Jafari Z, Kamalinejad M (2017) The Effect of Trigonella Foenum Graceum L. (Fenugreek) on Metabolic Syndrome: An Accidental Finding. J Metabolic Synd 6: 233. DOI: 10.4172/2167-0943.1000233

Copyright: © 2017 Oveidzadeh L, et al. This is an open-access article distributed under the terms of the creative commons attribution license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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