Reach Us +44-1477412632
The Importance of the and#8220;Obesity Paradoxand#8221; in Cardiac Surgery | OMICS International
ISSN: 2329-9495
Angiology: Open Access
Make the best use of Scientific Research and information from our 700+ peer reviewed, Open Access Journals that operates with the help of 50,000+ Editorial Board Members and esteemed reviewers and 1000+ Scientific associations in Medical, Clinical, Pharmaceutical, Engineering, Technology and Management Fields.
Meet Inspiring Speakers and Experts at our 3000+ Global Conferenceseries Events with over 600+ Conferences, 1200+ Symposiums and 1200+ Workshops on
Medical, Pharma, Engineering, Science, Technology and Business

The Importance of the “Obesity Paradox” in Cardiac Surgery

Carmelo Dominici1 , Giovanni Mariscalco2*, Saverio Nardella1 and Daniele Maselli1

1Department of Cardiovascular Surgery, Cardiac Surgery Unit, S. Anna Hospital Catanzaro, Italy.

2Leicester Cardiovascular Biomedical Research Unit and Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester, UK.

Corresponding Author:
Giovanni Mariscalco
Leicester Cardiovascular Biomedical
Research Unit and Department of Cardiovascular Sciences
University of Leicester, Glenfield Hospital, Leicester, UK
Tel: 4401162583019
E-mail: [email protected]

Received Date: May 20, 2016; Accepted Date: May 23, 2016; Published Date: May 31, 2016

Citation: Dominici C, Mariscalco G, Nardella1 G, Maselli D (2016) The Importance of the “Obesity Paradox” in Cardiac Surgery . Angiol 4:e115. doi:10.4172/2329-9495.1000e115

Copyright: © 2016 Dominici C, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Visit for more related articles at Angiology: Open Access


Obesity Paradox in Cardiac Surgery

Obesity is an increasingly chronic health condition, predisposing to coronary artery disease (CAD) and adverse cardiovascular events, having independent effects on hemodynamics and cardiovascular structures, contributing to the derangement of adipose tissue function and inflammatory pathways [1,2]. Obesity promotes endothelial dysfunction favouring atherosclerotic processes, reduces insulin sensitivity, and enhances free fatty acid turnover, thrombogenicity and leptin resistance [3]. In addition, obesity is a cluster of related risk factors including hypertension, diabetes, dyslipidaemia and renal dysfunction, and exacerbating the ongoing cardiovascular disease epidemic [1-3].

Therefore, the reported association between obesity and mortality is not unexpected, despite several studies in both general and disease specific populations have surprisingly reported paradoxical survival benefit in obese patients [4,5]. This inverse relationship between body fat composition and all-cause mortality is commonly labelled as “obesity paradox” [6]. However, prior attempts to firmly demonstrate this paradox and to identify its pathophysiologic mechanisms yielded conflicting results [1-3]. Plausible explanations include increased lean body mass, protective peripheral body fat, reduce inflammatory response, reverse epidemiology, and genetics [4-7].

This should not be certainly taken as an argument to encourage body weight excess, and the ample evidences of the correlation between obesity and death, especially in the long-term period, are indisputable [1,2]. However, why is so important the obesity paradox in cardiac surgery?

In an experimental swine model, high fat diet promoting obesity and renal inflammation prevented post-CPB acute kidney injury [7]. Consonant data have been observed in a high-fat feeding mice model inducing coronary atherosclerosis with related metabolic anaerobic stress changes [8]. During global ischemia, heart with induced coronary disease were markedly resistant to ischemic-reperfusion injury than non-disease heart, suggesting a protective preconditioning metabolic pathway [8]. Similarly, pigs fed a high-fat diet developing hyperlipidaemia in absence of significant weight gain were protected against myocardial ischemic-reperfusion injury [9].

Therefore, the complete understanding of underlying protective mechanisms behind the “obesity paradox” could improve clinical outcomes after cardiac surgery in the early perioperative period.


Select your language of interest to view the total content in your interested language
Post your comment

Share This Article

Relevant Topics

Article Usage

  • Total views: 8563
  • [From(publication date):
    June-2016 - Jan 21, 2019]
  • Breakdown by view type
  • HTML page views : 8456
  • PDF downloads : 107

Review summary

  1. Eric
    Posted on Aug 02 2016 at 2:25 pm
    The editorial highlights the role of obesity paradox in determining the outcomes and the recovery associated with cardiac surgeries. The author centralises the systemic risks associated with obesity which may pose a threat in the complete recovery of the patient. The article will help in guiding cardiologists to consider the various aspects related to obesity and plan suitable therapeutic strategies for the treatment of cardiac diseases in obese patients.

Post your comment

captcha   Reload  Can't read the image? click here to refresh

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2019-20
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri and Aquaculture Journals

Dr. Krish

[email protected]

+1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals


[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

ankara escort

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

pendik escort

[email protected]

1-702-714-7001Extn: 9042

© 2008- 2019 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version