alexa The Microbiome and Diet: Friend or Foe in the Future Treatment of Inflammatory Bowel Disease? | OMICS International
ISSN: 2327-5073
Clinical Microbiology: Open Access
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The Microbiome and Diet: Friend or Foe in the Future Treatment of Inflammatory Bowel Disease?

Udai P Singh*

Pathology, Microbiology and Immunology, School of Medicine, University of South Carolina, Columbia, SC 29208, USA

*Corresponding Author:
Udai P Singh
Pathology, Microbiology and Immunology
School of Medicine, University of South Carolina
Columbia, SC 29208, USA
Tel: +1-803-216-3423
Fax: +1-803-216-3413
E-mail: [email protected]

Received date: August 22, 2015; Accepted date: August 24, 2015; Published date: September 01, 2015

Citation: Singh UP (2015) The Microbiome and Diet: Friend or Foe in the Future Treatment of Inflammatory Bowel Disease?. Clin Microbiol 4:e127. doi: 10.4172/2327-5073.1000e127

Copyright: © 2015 Singh UP. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Abstract

It is well established that uncontrolled activation of effector immune cells in response to the gut microbiota triggers chronic inflammatory bowel disease (IBD) symptoms in genetically susceptible hosts. The exact cause(s) for IBD remains unknown. Previous studies have examined, in detail, how the gut microbiome, genetic susceptibility, and environmental stress may activate the immune responses associated with IBD. Recent studies show that a high fat diet alters the gut microbiota structure and function and facilitates the initiation and progression of immune responses responsible for IBD outcome. Some recent studies also clearly suggest that changes in pathobionts lead to an altered immune response and disease progression. This editorial focuses on some information provided in these studies and addresses how high fat diet induced alteration in the gut microbiota affect IBD progression. We provide some suggestions on how our current knowledge might be used to develop new dietary microbial and immune based modulation strategies for risk assessment and treatment of IBD.

Description

The intestine harbors nearly 100 trillion commensal bacteria that exert crucial effects on overall human health. Genetic studies on the community of gut microbes have shown that they have a role in the development of inflammatory bowel disease (IBD). They have also provided important landmarks in studies of IBD based on recent technological advances in sequencing, genomics, and bioinformatics. The microbiome is a key factor in establishing a balance between immune responses and tolerance to inflammation in the intestinal environment; that balance is required to maintain gut homeostasis.

Since the nineteenth and twentieth centuries, it has been recognized that the intestinal flora, including bacterial pathogens, are involved in the pathogenesis of IBD [1]. This conclusion is supported by several models of IBD in which animals did not develop symptoms of colitis in a germ-free environment. Further, almost 100 years ago, on the basis of clinical and pathologic similarities [2], an association was suggested among the microbiome, Crohn’s disease (CD), which is a form of IBD, and chronic inflammatory enteropathy in ruminants and other animals. The main symptoms of IBD in humans and animal models contain granulomas and, at that time, Mycobacterium avium subsp. paratuberculosis (MAP) was thought to act as an infectious etiologic agent to induce chronic inflammation [3]. This was also associated with the observation that MAP was identified in milk from infected cows [4], as well as modern-day water supplies [5]. The isolation of MAP from intestinal biopsies of patient with CD [6,7] also suggests that MAP plays a role in CD. We have shown a plausible mechanism of Ag-specific T-cell responses in experimental colitis driven by potent Ags conserved in MAP species [8]. This finding, together with recent identification and characterization of various microbiome species in the colon and ileum that clearly induce IBD or decrease its severity in humans opens a new paradigm for this field.

Over the past half-century, the incidence of IBD has been increasing in Western society at an alarming rate. Dietary intake, smoking, alcohol consumption, and altered sleep habits are the main triggers of IBD [9]. Dietary intake mediates microbiome species that affect diverse regulatory mechanisms, including both innate and adaptive immunity during the development of IBD [10]. Accumulating evidence suggests that the immunological lesions of IBD are accompanied by prominent infiltrates of cells, including T lymphocytes [11], macrophages, and neutrophils [12], mediated in part by changes in the gut microbiota. The chronic inflammation associated with IBD can be initiated by the emergence of proinflammatory pathobionts and a decline in the number of commensal microbiota [13,14].

Our interest in complementary and alternative medicine, together with a recent report that resveratrol, a plant-derived compound, improves gut microbiota dysbiosis induced by a high fat diet [15] as compared to regular diet, brings our attention to assessment of dietinduced dysbiosis as a driver of IBD pathogenesis. Changes in modern human dietary patterns, especially the widespread consumption of a diet high in fats and sugar, has changed the microbial community of the gut.

This is supported by a study showing that children with high-fat or plant-based diets have vastly different gut microbes than do those on a rich sugar and fat diet [16]. Another study has provided evidence that children who had received antibiotics had a greater risk of IBD than did those who had not, supporting observations that the microbial community affects the development and progression of IBD [17]. Similarly, in experimental model of spontaneous colitis, feeding subjects a Western diet rich in saturated milk fat worsened disease symptoms through an increase in the number of Th1 cells [18]. On the other hand, humans in a clinical study who were placed on either an meat-based diet and/or a plant-based diet showed increases in biletolerant microbes and decreases in firmicutes, which metabolize plant polysaccharides [19]. Further, a diet based on animal products reduced short-chain fatty acids (SCFAs) as a result of having a low dietary content of plant fibers [19]. This decrease in microbial production of SCFAs, which correlates with a decrease in mucosal barrier function, as well as variation in regulatory T-cell function (Tregs), increases disease severity [20]. Similarly, bacterial strains of Clostridia induce clustering of induced colonic Tregs that reduce the severity of experimental colitis [21]. This may be mediated by increased bioavailability of SCFAs, which induce TGF-β to mediate Tregs. These findings and other evidence clearly suggest that increased intake of high-fat Western diets is a critical factor in facilitating changes in the gut microbiome that then trigger autoimmune diseases such as IBD in humans.

Recent advances in understanding immune and microbiome interactions add an exciting new perspective to our understanding on the development of IBD and provide an avenue for possible new treatments. Further, based on the current extent of our knowledge of how diet alters immune response and tolerance across the population, it continues to be very difficult to translate results into conclusions and treatments. Thus, dietary modulation and its impact on the gut microbiome should be examined in detail in many experimental models of intestinal inflammation. This essential if we are to reach prudent, practical conclusions. However, the next major task for clinicians is to advance current understanding of host-microbe interactions that modify the gut microbiota and that may be important in the context of human diet.

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