alexa The PE/PPE Multigene Family of Mycobacteria and TB Vaccines | OMICS International
ISSN: 2379-1764
Advanced Techniques in Biology & Medicine
Make the best use of Scientific Research and information from our 700+ peer reviewed, Open Access Journals that operates with the help of 50,000+ Editorial Board Members and esteemed reviewers and 1000+ Scientific associations in Medical, Clinical, Pharmaceutical, Engineering, Technology and Management Fields.
Meet Inspiring Speakers and Experts at our 3000+ Global Conferenceseries Events with over 600+ Conferences, 1200+ Symposiums and 1200+ Workshops on
Medical, Pharma, Engineering, Science, Technology and Business

The PE/PPE Multigene Family of Mycobacteria and TB Vaccines

Michael J Brennan*

Aeras Global TB Vaccine Foundation, Scientific and Global Affairs, USA

Corresponding Author:
Michael J Brennan
Consultant, Aeras Global TB Vaccine Foundation
Scientific and Global Affairs
1405 Research Blvd/Rockville, MD 20850, USA,
Tel: 3016480155
E-mail: [email protected]

Received date: June 18, 2017; Accepted date: June 22, 2017; Published date: June 29, 2017

Citation: Brennan MJ (2017) The PE/PPE Multigene Family of Mycobacteria and TB Vaccines. Adv Tech Biol Med 5:231. doi:10.4172/2379-1764.1000231

Copyright: © 2017 Brennan MJ. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Visit for more related articles at Advanced Techniques in Biology & Medicine

Mycobacteria including Mycobacteria tuberculosis (Mtb) contain a multi-gene family, named the PE/PPE family. Mycobacterial strains contain about 165 genes, consisting of two major subfamilies the PE (containing the PE_PGRS group) and PPE, of which many of the constituents are very homologous (>50%). Since their discovery, scientists speculated about the role the members in this family might play in Mtb pathogenesis, immunity, evolution, and antigenic variation. Brennan et al. [1] in Issue 6 of Infection and Immunity, summarizes what is known about PE/PPEs with a particular focus on how they could be used in new TB vaccines. In fact, two TB vaccines presently being studied in clinical trials, GSK’s M72 and IDRI’s ID93, each contain a PPE protein. Another TB vaccine, the live Mtb mutant strain MtbΔPPE/ PE25-PE19 developed by the laboratories at the University of Pisa and Institute Pasteur, is a mutant which is missing two PEs and three PPEs, is under preclinical development. Evidence indicates that this vaccine is safe and is protective due to cross reactivity among the PE and PPEs in animal models for TB.

Numerous investigations over the past decade have demonstrated that certain representatives of this family display a variety of characteristics. They are found at the bacterial cell surface, can act as chaperones carrying proteins to the surface, interact with mitochondria leading to necrosis of cells and bind to immunologically active receptors like TLR2. The multiple PE/PPE genes have evolved along with the ESX regions of mycobacteria and are often associated with ESX regions including ESX5 of Mtb.

Very recently, Camassa et al. [2], have shown that Mtb knock-out mutant of PE_PGRS33 (in Mtb strain H37Rv) acts like a persistor mutant, being more virulent over time than the parental/wildtype in the murine model. It is very unusual for an attenuated mutant to be more virulent in an animal model of the disease and the studies indicate that (1) the Mtb is mostly extracellular in the lung and (2) the mutant is associated with chronic TB disease, not early infection. Together with the additional evidence that truncations of PE_PGRS33 may be associated with the absence of caseous necrosis and with the amplified transmission of Mtb, this points to the significance of PE_PGRS33 and other representatives of this multigene family.

In summary, the variety of important functions assigned to PE/ PPEs suggests that they should be included in a new TB vaccine. The PE/PPEs can elicit strong TH1 and also humoral immune responses and some have already been shown to be protective in preclinical studies. Immunological cross reactivity is an important feature of the numerous PE/PPEs. Success in the future rests with scientists, who are fearless enough to investigate and explore the PE/PPEs of mycobacteria.


Select your language of interest to view the total content in your interested language
Post your comment

Share This Article

Relevant Topics

Recommended Conferences

Article Usage

  • Total views: 492
  • [From(publication date):
    August-2017 - Aug 21, 2018]
  • Breakdown by view type
  • HTML page views : 452
  • PDF downloads : 40

Post your comment

captcha   Reload  Can't read the image? click here to refresh

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

+1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A


[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals


porn sex

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

Gaziantep Escort

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A


[email protected]

1-702-714-7001Extn: 9037


James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

mp3 indir

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals


Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T


[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version