alexa Thoracic Spinal Cord Atrophy Due to Vitamin B12 Deficiency | OMICS International
ISSN: 2329-6895
Journal of Neurological Disorders
Make the best use of Scientific Research and information from our 700+ peer reviewed, Open Access Journals that operates with the help of 50,000+ Editorial Board Members and esteemed reviewers and 1000+ Scientific associations in Medical, Clinical, Pharmaceutical, Engineering, Technology and Management Fields.
Meet Inspiring Speakers and Experts at our 3000+ Global Conferenceseries Events with over 600+ Conferences, 1200+ Symposiums and 1200+ Workshops on
Medical, Pharma, Engineering, Science, Technology and Business

Thoracic Spinal Cord Atrophy Due to Vitamin B12 Deficiency

Frederico Carvalho de Medeiros1*, Lucas Alverne Freitas de Albuquerque2 and Cíntia Alvarenga Pereira1
1Frederico Carvalho de Medeiros, Department of Neurology, Santa Casa Hospital of Belo Horizonte, Minas Gerais, Brazil
2Lucas Alvernia Freitas de Albuquerque, Department of Neurosurgery, Santa Casa Hospital of Belo Horizonte, Minas Gerais, Brazil
Corresponding Author : Frederico Carvalho de Medeiros
Rua Santo Antonio do Monte
139, apt 01, Santo Antônio
Belo Horizonte, MG, 30330-220, Brazil
Tel: +55(31)93351517
E-mail: [email protected]
Received August 06, 2014; Accepted September 06, 2014; Published September 08, 2014
Citation: Medeiros FC, Albuquerque LAF, Pereira CA (2014) Thoracic Spinal Cord Atrophy Due to Vitamin B12 Deficiency. J Neurol Disord 2:i101. doi: 10.4172/2329-6895.1000i101
Copyright: © 2014 Medeiros FC, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Related article at
DownloadPubmed DownloadScholar Google

Visit for more related articles at Journal of Neurological Disorders

Abstract

A 57 year-old woman searched for a neurological Service for the first time when she was 45-year-old, complaining about weakness in lower limbs for ten months period. The physical examination reported was of sensitive level at T5, reduced proprioception, Romberg’s sign and ataxic gait. A Work up discovered a low Vitamin B12 level of 64pg/ml. Vitamin B12 reposition was initiated, however the patient failed to follow up.

Description
A 57 year-old woman searched for a neurological Service for the first time when she was 45-year-old, complaining about weakness in lower limbs for ten months period. The physical examination reported was of sensitive level at T5, reduced proprioception, Romberg’s sign and ataxic gait. A Work up discovered a low Vitamin B12 level of 64pg/ml. Vitamin B12 reposition was initiated, however the patient failed to follow up.
The patient looked for our Hospital with 57-year-old moving herself using a walker. A cervical and thoracic spinal cord MRI was performed (Figure 1). A sagittal and axial thoracic spinal MRI showed diffuse spinal cord atrophy with preservation of signal intensity at T2-weighted image (T2WI).
The myelopathy of vitamin B12 deficiency is rare and normally affect the lower cervical and upper thoracic regions [1,2]. Extensive thoracic myelopathy due to vitamin B12 deficiency is very rare [2]. The predominant MRI finding is demyelination involving the dorsal columns, showed by the hyperintense signal at T2 [1-3]. In these cases the clinical and radiological improvements are possible if early therapy is initiated promptly [1].
Spinal cord atrophy secondary to prolonged vitamin B12 deficiency is an extremely rare complication of the myelopathy. We believe that delayed treatment and prolonged inadequate therapy induces irreversible axonal degeneration with progressive fibrous gliosis, promoting spinal cord atrophy (Figure 1) [1,3]. In this case it was associated to a very poor response to vitamin B12 replacement.
Acknowledgement
The authors would like to acknowledge João Lucas Breder for assistance with preparation of Figure1.
References


Figures at a glance

image
Figure 1
Select your language of interest to view the total content in your interested language
Post your comment

Share This Article

Relevant Topics

Recommended Conferences

Article Usage

  • Total views: 13068
  • [From(publication date):
    September-2014 - Dec 18, 2017]
  • Breakdown by view type
  • HTML page views : 9227
  • PDF downloads : 3841
 

Post your comment

captcha   Reload  Can't read the image? click here to refresh

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

agriaqu[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version