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The clinical and analytical specificity and sensitivity are dependent on the advancement of laboratory tools. Hereupon, one of the main aims of new laboratory equipments is to develop the Limitations of Detection (LOD) of trace markers. Although the routine use of low LOD markers may be critical in clinical diagnoses but, the quality control parameters should be managed during their measurements. It is obvious that the data assurances are associated to tools, methods and materials, but a simple concept must be followed for data quality analysis in clinical laboratories. Here, some IQC parameters are mentioned to be applied and evaluated by staffs in clinical laboratories.