alexa
Reach Us +44-1477412632
Triple Ectopic Thyroid: A Case Report and Review of Literature | OMICS International
ISSN: 2167-7948
Journal of Thyroid Disorders & Therapy
Make the best use of Scientific Research and information from our 700+ peer reviewed, Open Access Journals that operates with the help of 50,000+ Editorial Board Members and esteemed reviewers and 1000+ Scientific associations in Medical, Clinical, Pharmaceutical, Engineering, Technology and Management Fields.
Meet Inspiring Speakers and Experts at our 3000+ Global Conferenceseries Events with over 600+ Conferences, 1200+ Symposiums and 1200+ Workshops on
Medical, Pharma, Engineering, Science, Technology and Business

Triple Ectopic Thyroid: A Case Report and Review of Literature

Kuramoto R1, Oikawa K1, Fujita K1, Oridate N2,3* and Fukuda S2
1Department of Otolaryngology, Tenshi Hospital, Sapporo, Japan
2Department of Otolaryngology-Head and Neck Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan
3Department of Otolaryngology-Head and Neck Surgery, Yokohama City University Graduate School of Medicine and School of Medicine, Yokohama, Japan
Corresponding Author : Nobuhiko Oridate
Department of Otolaryngology-Head and Neck Surgery
Yokohama City University Graduate School of Medicine and School of Medicine
Fukuura 3-9, Kanazawa-ku, Yokohama 236-0004, Japan
Tel: +81-45-787-2687
Fax: +81-45-783-2580
E-mail: [email protected]
Received June 24, 2013; Accepted August 05, 2013; Published August 08, 2013
Citation: Kuramoto R, Oikawa K, Fujita K, Oridate N, Fukuda S (2013) Triple Ectopic Thyroid: A Case Report and Review of Literature. Thyroid Disorders Ther 2:126. doi:10.4172/2167-7948.1000126
Copyright: © 2013 Kuramoto R, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Visit for more related articles at Journal of Thyroid Disorders & Therapy

Abstract

Ectopic thyroid is an embryological abnormality resulting from the aberrance or failure of thyroid gland descent. We present a case of triple ectopic thyroid in a 10-year-old girl. Plain computed tomography and Tc-99m scans showed three ectopic thyroids located near the hyoid bone with no normally positioned thyroid. The patient was euthyroid at presentation, but hypothyroidism was observed five months later. On treatment with levothyroxine (75 μg/day), FT4 and TSH returned to normal ranges. Cases of multiple ectopic thyroidare are rare, with the present case being only the third case of triple ectopic thyroid presented. A careful follow-up is required because the incidence of malignancies associated with ectopic thyroid can be as high as 10%. Surgical treatment should be considered when the patient shows symptoms such as dysphagia, dysphonia, bleeding or dyspnea.

Keywords
Multiple Thyroid Ectopy; Malignancy
Case Report
A 10-year-old girl was admitted with a 1-month history of neck swelling. The lesion was a 20 mm × 15 mm soft, movable mass in the midline of the neck (Figure 1). Ultra sonography showed a solid midline mass, and plain computed tomography (CT) scans demonstrated three high-density masses around the hyoid bone near the base of tongue, pre hyoid region and pre-tracheal region, respectively (Figure 2). No normally positioned thyroid gland was observed. Laryngeal fiber scopic examination revealed a mass with a smooth surface at the base of tongue (Figure 3). The patient did not present with any airway obstruction or dysphagia. Tc-99m scans showed uptake in the region of the three masses. No uptake was seen in the normal thyroid (pretracheal) position (Figure 4). Serum FT3, FT4 and thyroid-stimulating hormone (TSH) levels were within normal ranges at presentation, although the thyroglobulin (Tg) level was elevated (218.7 μIU/L), and other laboratory tests were also within normal limits. Decreased FT4 (0.7 ng/dl), increased TSH (5.71 μIU/L) and further increased Tg (376.2 μg/L) levels were observed five months after the initial examination. The patients had screening test for congenital hypothyroidism and the abnormality was not pointed out. The patients have no the mental disability. A thyrotropin-releasing hormone (TRH) stimulation test was performed to evaluate the function of the pituitary gland.TSH level peaked 15 minutes after an intravenous bolus of TRH with the result within normal limits (Table 1). Although the reason why the patient became slightly hypothyroidism within five months was unknown, we decided to give levothyroxine to the patient because the swell of the ectopic thyroid and Tg elevation might be compensatory reaction for hypothyroidism. Treatment with levothyroxine (75 μg/day) resulted in FT4 and TSH levels returning to normal ranges together with a gradual decrease in Tg level.
Discussion
Ectopic thyroid, which was first reported in 1869 by Hickman, is an embryological abnormality [1]. The thyroid gland descends from the foramen caecum of the tongue to its final pre-tracheal position through the thyroglossal duct by 7 weeks gestation [2]. Ectopic thyroid arises from an aberrance or failure of its descent. Ectopic thyroid tissue usually occurs between the foramen caecum and the mediastinum.
Lingual thyroid (ectopic thyroid occurring at the base of tongue) is the most common type, accounting for 90% of all ectopic thyroids [3]. Other sites, all rare, include under the tongue, above the hyoid bone, in front of the larynx, the mediastinum, duodenum, esophagus, lungs and so on. A few cases of dual ectopic thyroid have been reported [4-5]. In most dual thyroid cases; the lesion is lingual and subhyoid. Only two cases of triple ectopic thyroid have been reported [6-7], with the present case being the third case.
The prevalence of ectopic thyroid varies between 1:100000 and 1:300000 and its clinical incidence is reported to range from 1:4000 to 1:10000.A male to female ratio of 1:4 is documented [8]. In 25% of cases, orthotropic thyroid tissue is also observed at the normal pretracheal position [2].
Most patients with ectopic thyroid are asymptomatic [9]; however, symptoms such as dysphagia, dysphonia, bleeding or dyspnea may occur as the ectopic thyroid (especially in cases of lingual thyroid) grows [10-11]. Thyroid function is either hypothyroid or euthyroid in most cases. About 33-62% of the patients with ectopic thyroid showed hypothyroidism with increased levels of TSH [12].A few cases of hyperthyroid have also been reported [13].
Thyroid scanning using technetium Tc-99m is the most useful tool for definitive diagnosis [8]. Thyroid scanning detects the presence of thyroid tissue in other sites. Additional CT scans or MRI may help in defining the extent or location of the ectopic thyroid gland. Differential diagnosis includes angioma, adenoma, fibroma, lipoma, lymphangioma and cysts in the neck [8], with thyroglossal duct cysts, which arise from epithelial remnants of the thyroglossal duct, also representing a major differential diagnosis. Thyroglossal duct cysts present as low-density masses on plain CT, whereas ectopic thyroid shows a high density as in our case [7].
Management of ectopic thyroid is controversial. If the patient is both asymptomatic and euthyroid, no treatment is required. The main concern is the risk of thyroid carcinomas, in most cases papillary carcinomas [14], arising from the ectopic thyroid tissue. Jarvis et al. reported that the risk of malignancies in cases of ectopic thyroid was 1% in 1969 [15]. This figure was quoted from a review published in 1934. Massine et al. reviewed 28 case reports of lingual thyroid carcinoma [16] and, in review of the English literature, we found that 33 cases of ectopic thyroid carcinoma has been reported in approximately 400 cases of ectopic thyroid (Table 2). This indicates that the potential for malignancy is as high as 10%. The reason for the very high incidence malignancy (10%) in ectopic thyroid tissue that we found in the literature is unknown. One possible reason is that ectopic thyroid tissue only calls medical attention when there is an enlargement due to infection, tumors etc. Asymptomatic lingual thyroid glands were found in as much as 10% of the autopsies. Therefore, ectopic thyroid glands are probably much more common than it is reported. In this sense the rate malignancy may be probably much lower than 10%. Even though, careful follow-up for cases of ectopic thyroid is necessary. In our case, fine needle aspiration cytology would be needed when the ectopic gland has more enlarged.
It should be also kept in mind that, even if the patient is euthyroid, the patient could later develop hypothyroidism as in our case. If the patient is hypothyroid with an elevated TSH, thyroid hormone therapy might prevent enlargement or malignant transformation of the ectopic thyroid [9,17]. Surgical treatment should be considered when the patient is symptomatic [18]. Also, cervical ectopic thyroids may be removed surgically for cosmetic reasons. Several external or trans-oral surgical approaches have been described [19].
References

Tables and Figures at a glance

Figure Figure
Table 1 Table 2

 

Figures at a glance

Figure Figure Figure Figure
Figure 1 Figure 2 Figure 3 Figure 4
Select your language of interest to view the total content in your interested language
Post your comment

Share This Article

Relevant Topics

Article Usage

  • Total views: 11934
  • [From(publication date):
    October-2013 - Nov 20, 2018]
  • Breakdown by view type
  • HTML page views : 8166
  • PDF downloads : 3768
 

Post your comment

captcha   Reload  Can't read the image? click here to refresh

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri and Aquaculture Journals

Dr. Krish

[email protected]

+1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

me[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version