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Homalomena aromatica (spreng) Scott (Araceae) is naturally localized in Assam, Arunachal Pradesh, Nagaland and Tripura. The plant is used by local people in various inflammatory conditions and gastric disorders, jaundice, diarrhoea etc. The preset study was undertaken to evaluate the antiulcer properties of the ethanolic extract of the root of Homalomena aromatica using HCl-Ethanol, cold restraint stress and indomethacin induced ulcer models in Wistar rat. Various biochemical and antioxidant enzymes in gastric mucosa, liver and serum were analyzed along with histological study. The extract showed ulcero protective activity in all the models at the highest dose i.e. 200 mg/ kg. The levels of various biochemical enzymatic and ulcer parameters were normalized after the treatment regime. HPTLC data showed the presence of gallic acid and quercetin amongst other constituents. The extract showed potential ulcero protective property in animal models of ulcer.