alexa Unawareness of Involuntary Nature of Hemichorea-hemiballism due to Acute Cortical Stroke | OMICS International
ISSN: 2155-9562
Journal of Neurology & Neurophysiology

Like us on:

Make the best use of Scientific Research and information from our 700+ peer reviewed, Open Access Journals that operates with the help of 50,000+ Editorial Board Members and esteemed reviewers and 1000+ Scientific associations in Medical, Clinical, Pharmaceutical, Engineering, Technology and Management Fields.
Meet Inspiring Speakers and Experts at our 3000+ Global Conferenceseries Events with over 600+ Conferences, 1200+ Symposiums and 1200+ Workshops on
Medical, Pharma, Engineering, Science, Technology and Business

Unawareness of Involuntary Nature of Hemichorea-hemiballism due to Acute Cortical Stroke

Judith Navarro-Otano1, Juan J Mengual2, Alvaro Cervera3, Yaroslau Compta1 and Francesc Valldeoriola1*

1Parkinson’s Disease and Movement Disorders Unit, Neurology Service, Hospital Clinic, University of Barcelona, Spain

2Neurology Service, Hospital Moises Broggi, Sant Joan Despi, Spain

3Stroke Unit, Neurology Service, Hospital Clinic, University of Barcelona, Spain

Corresponding Author:
Francesc Valldeoriola
Parkinson’s Disease and Movement Disorders Unit
Neurology Service, Clinical Institute of Neuroscience
Hospital Clinic de Barcelona, Spain
E-mail: [email protected]

Received date: April 24, 2014; Accepted dat: August 12, 2014; Published date: August 17, 2014

Citation: Navarro-Otano J, Mengual JJ, Cervera A, Compta Y and Valldeoriola F (2014) Unawareness of Involuntary Nature of Hemichoreahemiballism due to Acute Cortical Stroke. J Neurol Neurophysiol 5:217. doi:10.4172/2155-9562.1000217

Copyright: © 2014 Navarro-Otano J, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Visit for more related articles at Journal of Neurology & Neurophysiology

Commentary

Hemichorea-hemiballism is an uncommon complication from acute stroke (less than 1%) [1]. Although it is more commonly associated with basal ganglia lesions, hyperkinetic movements due to cortical infarction sparing subcortical structures are not unusual. A recent review has reported that 27 out of 2009 patients demonstrated hemichorea after a stroke and among them 6 suffered from a cortical stroke [2]. Denial of these symptoms is a rare phenomenon that has been reported in basal ganglia but not in cortical lesions [3-5], though anosognosia is well-recognised with (mostly right-sided) parietal damage [6]. We are reporting a case of denial of the involuntary nature of acute hemichorea-hemiballism in a patient with right cortical infarction, sparing the basal ganglia.

A 51-year old, righted-handed man, without any known past medical history or treatment, was admitted to our Stroke Unit in June, 2011 because of regressive paralysis of the left limbs, followed three hours later by acute hemichorea-hemiballism involving face, neck, and left arm and leg. Upon admission, the patient was fully conscious. Visual fields and extraocular movements were normal. Muscle strength was preserved in all four limbs and plantar responses were flexor. There was a light decrease in tactile and thermal sensation in the left limbs with tactile extinction upon simultaneous touch of the legs but not of the arms. Distal choreic movements, as well as ballistic proximal movements of the left arm and leg were observed. The patient tried to redirect the ballistic movements through pseudo-purpose ones, denying them being involuntary, providing odd explanations for his ballistic movements. As an example, the patient claimed that his involuntary arm jerks towards the opposite shoulder were with the intent to scratch his shoulder.

A computerized tomography performed six hours after the onset of the symptoms, showed a hypodense area in the vascular field, supplied by the right middle cerebral artery. An MRI with 1.5T dWI sequences was performed within the first 24 hours. It showed an acute ischemic stroke involving the right temporo-parietal cortex, the insular cortex and the operculum. The basal ganglia were totally spared (Figure 1). The first vascular ultrasound performed while movements were present, showed a TIBI 3 pattern in the right middle cerebral artery, suggestive of a distal occlusion. The doppler ultrasound and the angio-MRI performed after the movements had disappeared, were normal.

Figure

Figure 1: MR- diffusion image showing acute ischemic stroke involving right temporo-parietal cortex, insular cortex and the operculum.

A few hours after admission, there was just a hint of the initial abnormal movements, and these quickly subsided thereafter. Throughout the entire process, the patient acknowledged the movements but denied them being involuntary. He was discharged and prescribed acetylsalicylic acid 100mg/day and atorvastatin 80 mg/day.

Our hypothesis is that the cortical right lesion, involving the temporo-parietal junction, could have been responsible for both the involuntary movement as well as the lack of awareness of the involuntary nature of the movement. The mechanistic basis for the involuntary movement might be due to either the interruption of excitatory cortical projections to basal ganglia, with secondary dysfunction of striatum [7], or sensory deafferentation and subsequent lack of cortical inhibition of the motor output [6]. In this regard, metabolic investigations such as an SPECT/PET which were not available in this case, might have highlighted hypometabolism of the striatum and/or frontal cortex (disconnection syndrome or diaschisis). On the other hand, direct involvement of highly associative parietal areas, implied in self-awareness, might have accounted for the denial of the involuntary movements in our patient. The insula, which was acutely damaged in this case as well, has also been involved in the integration of self-awareness of one’s body parts’ functioning [8].

The quick recovery of the involuntary movement may be due to an acute transient ischemic functional damage to the corticobasal circuit. After a complete diagnostic work-up, the stroke was classified as undetermined etiology according to TOAST classification [9].

We acknowledge that an acute EEG might have helped to rule out the possibility of partial seizures. Still, this possibility was unlikely from a clinical point of view, since the movement was not repetitive nor was it stereotyped. Myoclonus was not present at any time and consciousness was fully preserved.

A similar case with insular infarction and anosognosia of the resulting chorea was described in 1991 [5]. Basal ganglia involvement was present then also, however it was different to the limited cortical damage in our case. Furthermore, our patient did not have proper anosognosia of the abnormal movement itself (he was aware of his limbs moving), but of the involuntary nature of these movements.

In conclusion, though cortical right lesions with secondary negligence are quite common, this is the first report of unawareness of the involuntary stroke-induced abnormal movement in the absence of basal ganglia damage.

References

Select your language of interest to view the total content in your interested language
Post your comment

Share This Article

Relevant Topics

Recommended Conferences

Article Usage

  • Total views: 12073
  • [From(publication date):
    August-2014 - Jun 21, 2018]
  • Breakdown by view type
  • HTML page views : 8315
  • PDF downloads : 3758
 

Post your comment

captcha   Reload  Can't read the image? click here to refresh

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

+1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
Leave Your Message 24x7