Review of Vaccine Induced Immune Overload and the Resulting Epidemics of Type 1 Diabetes and Metabolic Syndrome, Emphasis on Explaining the Recent Accelerations in the Risk of Prediabetes and other Immune Mediated Diseases

There has been an epidemic of inflammatory diseases that has paralleled the epidemic on iatrogenic immune stimulation with vaccines. Extensive evidence links vaccine induced immune over load with the epidemic of type 1 diabetes. More recent data indicates that obesity, type 2 diabetes and other components of metabolic syndrome are highly associated with immunization and may be manifestations of the negative feedback loop of the immune system reacting to the immune overload. The epidemic of diabetes/prediabetes appears to be accelerating at a time when the prevalence of obesity has stabilized, indicating that the negative feedback system of the immune system has been over whelmed. The theory of vaccine induced immune overload can explain the key observations that have confounded many competing hypothesis. The current paper reviews the evidence that vaccine induced immune overload explains the disconnect between the increase in prediabetes and nonalcoholic fatty liver at a time when the obesity epidemic is waning in children.


Introduction
Twenty years ago it was predicted that a massive increase in immunization would result in a massive increase in people with chronic immune related diseases like type 1 diabetes, autoimmune diseases, and asthma [1]. A massive increase in immunization has occurred. In the United States for example since just 1999 children are scheduled to routinely receive over 80 additional vaccines over their childhood as explained below. The increase in immunization has been followed by a huge increase in inflammation associated disorders. Diseases like autism, type 1 diabetes, asthma, food allergies, many autoimmune diseases, obesity, type 2 diabetes, NASH and metabolic syndrome have increased many fold in children. The rate of change of several closely followed diseases appear to be accelerating while others have decelerated. This paper describes how the theory of vaccine induced immune overload can explain many observations about the changes in the epidemics.
Many hypothesis have been proposed to find alternate explanations for these epidemics, such as the hygiene hypothesis for autoimmune diseases and poor diet or decreased exercise for the obesity epidemic. These hypothesis don't readily explain the recent changes in the rates of these diseases. For example the prevalence of obesity in US children has stabilized while junk food and leisure activities persists, and the epidemics of autoimmune diseases continue to rise at a time where hygiene does not seem to increase.
Recently publications have provided evidence that vaccines are responsible for the epidemics of both autoimmune diseases such as type 1 diabetes as well as the epidemic of type 2 diabetes, obesity and metabolic syndrome [2]. One major problem with vaccines is the concept of one size fits all. Package inserts of almost all vaccines recommend a dose based on age. In order for a vaccine to be a commercial success it is expected to induce a protective immune response in well over 90% of children. In order for this to happen a dose, based on age, must stimulate a protective immune response in those with the weakest immune system. In the process of doing this, the other 90% or more of children have their immune system over stimulated. The process of over stimulating the immune system time and time again increases the risk of inflammatory diseases like autoimmune diseases, and allergies which cause even more inflammation. The clinical manifestation of disease depends on one's physiologic response to inflammation as has previously been reviewed [3]. Inflammation causes the release of cytokines which can trigger autoimmune diseases but also stimulate cortisol production, the major negative feedback loop of the immune system. According to the theory inflammation induced cortisol production varies based on race [3] which can be explained by the presence of genes that alter cortisol production. Individuals who produce a lot of cortisol in response to inflammation have a tendency to develop a Cushingoid like response that includes obesity, type 2 diabetes/insulin resistance, hypertension, and dyslipidemia which is called metabolic syndrome.
Evidence that vaccines cause type 1 diabetes has been well established. Data from a large prospective clinical trial of the Haemophilus vaccine [4] as well as epidemiology data [5] support vaccines as a major causative agent for type 1 diabetes. The data from the clinical trial validates an animal toxicity model [4]. The findings were verified by others [6]. Discontinuation of vaccines has been repeatedly shown to be followed by declines in the rates of type 1 diabetes [5,7]. Evidence that vaccines cause type 2 diabetes, obesity and metabolic syndrome has been reviewed recently [2]. Evidence includes the observation that the discontinuation of school age BCG vaccination in Japan was followed by a decrease in type 2 diabetes in children in Japan [8].

Disconnect between the Acceleration Diabetes Epidemic and the Stabilization of the Prevalence of Obesity
The theory of vaccine induced immune overload explains the acceleration of the diabetes epidemic at a time when the obesity epidemic has stopped. Data from the United States shows that the epidemic of obesity in children 12-19 has ended [11] however during a time when there was no increase in obesity in children age 12-19 the rates of prediabetes or diabetes increased from 9% to 23%. According to an alternate hypothesis, obesity was causing the diabetes epidemic and one would expect no increase in diabetes or prediabetes when the rates of obesity were constant. However the theory of vaccine induced immune over load explains the observation. According to the theory the obesity epidemic was caused by the physiological response to immune stimulation and the resulting cortisol production of the negative feedback loop of the immune system [2,3,12,13]. As the number of vaccines increased the negative feedback loop reached its maximum and the obesity rates stabilized. At that point additional vaccine induced immune stimulation was not met by an increase in negative feedback and the epidemic of diabetes (inflammation induced islet cell damage) increased.

Disconnect between Epidemics of Diabetes and other Components of Metabolic Syndrome
As discussed above, data on children age 12-19 showed the rates of obesity went from 18% to 20% (not statistically significant) while diabetes/prediabetes went from 9% to 23% in the years 1999-2000 to 2007-2008 [11]. During this time frame other components of metabolic syndrome experienced no increases. There was no increase in hypertension or decreases in HDL. LDL levels also did not rise. These findings can be explained by the vaccine induced immune overload theory. The negative feedback loop comprising cortisol production reached its maximum and further immune stimulation lead to immune destruction of islet cells, similar to what occurs in type 1 diabetes, without rises in symptoms consistent with increased cortisol production, obesity, hypertension, dyslipidemia.

Type 1.5 Diabetes in Children, Double Diabetes
There has been a recent increase in the diagnosis of children with features of both type 1 and type 2 diabetes [14] a condition called double diabetes or type 1.5 diabetes. This condition is new. A similar condition is being diagnosed much more frequently in adults as well and is called LADA, latent autoimmune diabetes in adults, as well as type 1.5 diabetes. The theory of immune overload explains the increasing prevalence of this condition. Under conditions of low vaccination and low immune stimulation, those who develop autoimmune type 1 diabetes include those with a low cortisol response to inflammation, while those who develop type II diabetes/metabolic syndrome include those which have a very high cortisol response to inflammation [3]. As the increasing number of vaccines increases inflammation those with a moderate cortisol response to inflammation develop diabetes. In persons with a moderate cortisol response, the individuals do not produce enough cortisol to prevent inflammation induced destruction of islet cells, type 1 diabetes, however they make enough cortisol to develop insulin resistance and symptoms of type 2 diabetes.

Decreasing Importance of High risk MHC in Developing Type 1 Diabetes
It has been shown that with progression of time and the increase in the epidemic of type 1 diabetes that the proportion of children with high risk MHC genotypes for type 1 diabetes is decreasing [15]. This can be explained by vaccine induced immune overload. When the underlying level of inflammation in the population is low, those with high risk genes are more likely to develop type 1 diabetes. In an environment where the underlying level of inflammation in the population is elevated, because of extensive immunization, high risk MHC genotypes are less important to the development of the disease because elevated cytokines and activated immune cells are the key drivers of the disease.

Epidemic of NASH
NASH is a relatively new disease and was first described in 1979-1980 and is a type of fatty liver disease. NASH was shown to afflict 3% of children [16] in an autopsy study of children who died from 1993 to 2003. The study indicated fatty liver disease was found in 38% of obese children but was found in 5% of normal weight children. A recent paper indicated the percent of children aged 12-19 with elevated liver enzymes, specifically alanine aminotransferase levels, increased from 3.9% to 10.7% from 1988-1994 to 2007-2010 [17]. While there have been no direct epidemiology studies between NASH and vaccines, this epidemic can be explained by the rise in vaccine induced inflammation and vaccine induced diabetes. NASH is considered caused by multiple hits. One predisposing factor is the diabetes which as explained above is caused by vaccines. Another hit is cytokines [18] which are also caused by vaccine induced inflammation [2].

Parallel Epidemics of Inflammatory Diseases
The theory of vaccine induced immune overload explains the parallel epidemics of multiple different autoimmune diseases. It is a known fact that the pathophysiology is shared in many autoimmune and inflammatory diseases. Patients with autoimmune disease often have more than one autoimmune disease or have a family history of multiple different autoimmune diseases. It is thus not surprising that many inflammatory diseases are increasing along with type 1 diabetes, in fact it is expected. A wide variety of diseases have been reported to increasing in children. There are insufficient data to know if the prevalence of the majority of inflammatory diseases is increasing. However given the number and variety diseases that are reported to be increasing in children it is likely many more also increasing.
Epidemiology studies show a close linkage between type 1 diabetes and other autoimmune diseases. Type 1 diabetes is strongly linked with other autoimmune diseases in Type II polyglandular autoimmune syndrome [19]. In this syndrome 52% of patients have diabetes mellitus, 69% have autoimmune thyroid disease and 100% have Addison's disease. Patients with type 1 diabetes and their close relatives are at increased risk for organ specific autoimmune disease [20]. Some of the epidemiology data comes from studies of families where several members have autoimmune disease. Family studies indicate type 1 diabetes is linked to the development of several different autoimmune diseases including organ specific autoimmune diseases and rheumatoid diseases. Close relatives of patients with type 1 diabetes have an increased risk of a wide variety of different autoantibodies [21,22]. It has been found that depending on the family, type 1 diabetes is linked with either an increased risk of an organ specific autoimmune disease or a rheumatoid disease [23]. A large study of Mennonites showed a linkage between type 1 diabetes and other autoimmune diseases including organ specific and rheumatoid diseases [24].
Immune stimulation with alpha interferon increases the risk of type 1 diabetes and a wide variety of other autoimmune diseases. People receive alpha interferon for the treatment of viral hepatitis and cancers. Alpha interferon has been repeatedly reported to cause type 1 diabetes in humans [25][26][27][28]. One of 40 patients receiving alpha interferon in a Japanese study developed anti-islet cell antibodies [28]. An Italian study found 14 of 11,241 patients receiving alpha interferon developed diabetes mellitus [29]. Alpha interferon also increases the risk of organ specific autoimmune diseases such as thyroiditis and autoimmune rheumatic diseases such as SLE, rheumatoid arthritis, psoriasis and sarcoid [30]. It has been reported that upon the administration of alpha interferon that the same patient developed both rheumatoid and organ specific autoimmune diseases [31,32].
It is well accepted that the diagnosis of autism is epidemic. Many cases of autism have a strong inflammatory component and the epidemic has already been linked to vaccine induced overload [33]. Autism epidemiological linked to diabetes and those with autism have a family history of increased risk for autoimmune diseases. Attention deficit syndrome is epidemic and epidemiological linked to increased risk of immune disorders [34].
Many inflammatory mediated diseases other than diabetes are epidemic. The incidence of psoriasis has been reported to double in children [35]. Autoimmune anti-neutrophil cytoplasmic antibody vasculitis resulting in renal failure has also been increased [36]. Wegener's Granulomatosis has been reported to increase in children [37]. The incidence of inflammatory bowel disease is also increasing rapidly in children [38].
Data indicates vaccines can act to sensitize recipients to environmental antigens. The CDC [39] found several vaccines were associated with an increased risk of asthma including the Haemophilus influenzae type b, relative risk 1.18 (1.02 to 1.36) and hepatitis B vaccine 1.20 (1.13 to 1.27). It is not surprising then that there is a rise in food related allergens [40]. Peanut allergy has tripled in children since 1997 [41]. Immune mediated food related disease, celiac disease [42], has also increased substantially.

Conclusion
There has been an epidemic of inflammatory diseases that has paralleled the epidemic on iatrogenic immune stimulation with vaccines. The epidemic of diabetes/prediabetes appears to be accelerating at a time when the prevalence of obesity has stabilized, indicating that the negative feedback system of the immune system has been over whelmed. The theory of vaccine induced immune overload explains the key observations that have confounded many competing hypothesis. Unfortunately the prospective controlled trials of vaccines performed for licensure are either too small, too short in duration or inappropriately controlled (use other vaccines as controls) to appropriately study the relationship between vaccines and these epidemics. Furthermore most epidemiological studies performed after licensure of vaccines suffer from the same deficiencies. The conclusions of this paper are based on data from a single clinical trial, animal toxicity studies, and epidemiological studies. While it would be ideal to have more clinical trial data, industry and government have been reluctant to provide such information. However, conclusions regarding toxicity of many agents including cigarettes and asbestos were made without clinical trial data. The author believes that the sum of the data described and reviewed in this paper supports a casual relationship.