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ISSN: 2155-9864
Journal of Blood Disorders & Transfusion
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Vascular Disease in Multiple Sclerosis: A Real Thing?

Maria Grazia Caprio* and Marcello Mancini

Institute of Biostructures and Bioimaging, National Research Council, via Tommaso De Amicis, Naples, Italy

Corresponding Author:
Maria Grazia Caprio
Institute of Biostructures and Bioimaging, National Research Council
via Tommaso De Amicis-95-80145, Naples, Italy
Tel: +39 081 2203411
Fax: +39 081 2203498
E-mail: [email protected]

Received Date: October 05, 2016; Accepted Date: October 10, 2016; Published Date: October 14, 2016

Citation: Caprio MG, Mancini M (2016) Vascular Disease in Multiple Sclerosis: A Real Thing? J Blood Disord Transfus 7:370. doi:10.4172/2155-9864.1000370

Copyright: © 2016 Caprio MG, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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In recent years, great interest has been addressed to the association between vascular abnormalities and Multiple Sclerosis (MS) [1-8]. Many studies have shown that patients with MS have an increased cardiovascular risk and increased mortality related to stroke and cardiovascular disease compared to general population [9-13]. In addition, MS patients who had more than one cardiovascular risk factor at diagnosis were more likely to develop disabilities [2,14,15].

Some authors have recently demonstrated the existence of the cerebral perfusion abnormalities in MS patients [16]. The breakdown of the blood-brain barrier is a constant characteristic of MS focal lesions and is demonstrated by MR imaging [17,18]. Chronic lesions in MS patients, studied by Perfusion-weighted MRI, showed reduced perfusion, in contrast with enhancing lesions that showed increased perfusion. The presence of ischemic central focal areas, suggests that ischemia plays an important role in the development of some focal lesions in multiple sclerosis [19,20].

Law et al. [21] demonstrated a reduction in cerebral blood flow and a prolonged transit time in the periventricular regions of normal appearing white matter (NAWM) in MS patients than in controls. Other studies showed hypoperfusion in different regions (NAWM, and deep GM) independently of clinical MS form [22,23]. These changes in cerebral perfusion were correlated with clinical disability and neuropsychological impairment [24].

Moreover, many authors have studied the possible association between abnormal venous drainage and MS and have shown that multiple sclerosis is often associated with hemodynamic abnormalities and vascular changes [25-32].

Recently Zamboni introduced the concept of chronic cerebrospinal venous insufficiency (CCSVI) as a vascular condition characterized by anomalies of the main extra-cranial cerebrospinal venous outflow routes that interfere with normal venous outflow in patients with multiple sclerosis. This condition could cause an increase in iron vein deposit resulting in the characteristic inflammation of tissues of the MS [30,33-34]. However the studies that used Echo-color Doppler for the detection of CCSVI demonstrate too high variability of results. Therefore ultrasound is not a good screening methodology and further studies are needed to determine techniques that can measure venous cerebral outflow and are less operator-dependent and more objective.

Macro and micro circulation alterations can cause changes in the endothelial cells, resulting in immune-mediated reactions and inflammatory response. The autoimmune inflammation can lead to iron deposition and leukocyte infiltration. Furthermore the consequent production of vascular mediators by the immune system cells and endothelial activation and neovascularization can cause changes in the microcirculation [35-38]. This multiple vascular risk factors together with inflammatory factors, through interactions with neuronal cells and components of myelin, could lead to increased permeability of the blood brain barrier and neurovascular uncoupling up to neuronal damage. However, it is yet to be determined if the vascular damage is the primary causal factor of neurological disease, or secondary to inflammation-autoimmunity.

The frequent association between MS and vascular diseases suggests that vascular changes, might contribute to neuronal or degenerative dysfunction in patients with MS. However, the results in the literature are often discordant both as regards the association between vascular and brain damage in neurological diseases, both for the correlation between vascular disease and disability. Several studies are mostly "case-control" and there are no multi population studies.

In conclusion, more studies are needed to verify the existence of a real correlation between vascular damage and degenerative and demyelinating neurological diseases.


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  1. ruggieri francesco paolo
    Posted on Jan 13 2017 at 8:13 am
    leggo-rileggo ricerche,sempre utili ma,ai fini preventivi-cure-miglioramenti della qualità del sangue, della circolazione dal sistema linfatico fino al sistema cardio circolatorio arterioso-venoso, in sintesi a monte di tutte queste ricerche, nulla o quasi viene fatto ! Assurdo ma vero, si fanno ricerche a valle e giammai a monte e/o entrambe, per verifica potenziali miglioramenti, a seguito disintossicazione organismo e miglioramento della qualità del sangue ! Io indirizzerei la ricerca su alimenti-integratori tendenti ad agire ad ampio spettro ed in primis, con integratori naturali, quali quelli di origine marina pescati, giammai di allevamento !, che son ricchi di Minerali-Oligoelementi-aminoacidi-Vitamine e PLANCTON Marino ! integrati con Semi di Lino ammollati più volte, tre ricambi acqua a temperatura acqua a max 35° C o appena germogliati, utilizzati in insalata, con pezzettini di Cladodi, dette Paledi Fico D'india, Portulaca e, con abbondantissimo olio di oliva giallo oro al frantoio, da olive nere mature e polpaviola fino al nòcciolo , con aggiunta di 4-6 g di micro polvere di Ginkgo Biliba da foglie giallo oro e non Verdi, come in commercio e dieci grammi di micro polvere alcalina osso Seppia e/o da altro prodotto marino pescato, tipo Perle d'Ostrica marina,Coralli Marini, da Gussci di crostacei-molluschi, fino ai gusci delle telline !, due-tre grammi , di Polvere di Rosa Canina . Il tutto , per miglioramento di, qualità del sangue, livello qualità-funzionalità del SNC e, apparato cardio-circolatorio fino al sistema Linfatico e, con drenaggio dei metalli pesanti, eventualmente presenti. Tutto questo, con riscontro-verifica-risultati, prima-durante-dopo, con semplice analisi delcapello-nuca, detto mineralogramma,tanto ignorato da medici-medicina, ove si rilevanotutti i Minerali-Oligoelementi e metalli pesanti, a livello tissutale. Vi segnalo la" Mia bevanda alcalina osso Seppia ", a Costo Zero ! e, Senza alcun Effetto Collaterale-Rigetto ! ove, ho riscontrato, nei pazienti con SM a tutti i livelli, MIGLIORAMENTI NOTEVOLI QUALITà DEL SONNO, RITORNO A SOGNARE, MAGGIOR ENERGIA ALRISVEGLIO,QUINDI MIGLIORAMENTO NOTEVOLE E/O ELIMINAZIONE DELLA FATICA CRONICA ,RIDUZIONE-ELIMINAZIONE DI SPASMI MUSCOLARI E RELATIVO FORMICOLIO, DIMINUZIONE-AZZERAMENTO EMICRANIE VARIE !, mente-memoria migliore e più lucida e, DOPO TRE MESI, GUARITI DA ANEMIA CRONICA !! :
  2. Schelling Franz, M.D.
    Posted on Nov 20 2016 at 10:17 pm
    Bed-side observations of neuronal dysfunctions being [changeably] 'multiple in space and in time': How ought they to specifically associate to any vascular, degenerative, demyelinating, inflammatory, auto-immune, or also sclerosing process of a no better determined nature? It's a pity there is no biological inter-breeding test for showing these conceptual crossing's pervasive sterility. Why not rather seek to find out in which respects Cruveilhier's '1829-42', Rindfleisch's, Putnam & Adler's, Fog's (better 1964/5 than 1963!), Allen, and Adams indicated observations specifically relate? Might be less of a Sysiphean job :))

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