Reach Us +44-7447-215064
Vertebral Destruction Syndrome: From Knowledge to Practice | OMICS International
ISSN: 2165-7939
Journal of Spine
Make the best use of Scientific Research and information from our 700+ peer reviewed, Open Access Journals that operates with the help of 50,000+ Editorial Board Members and esteemed reviewers and 1000+ Scientific associations in Medical, Clinical, Pharmaceutical, Engineering, Technology and Management Fields.
Meet Inspiring Speakers and Experts at our 3000+ Global Conferenceseries Events with over 600+ Conferences, 1200+ Symposiums and 1200+ Workshops on Medical, Pharma, Engineering, Science, Technology and Business

Vertebral Destruction Syndrome: From Knowledge to Practice

Jose Maria Jimenez-Avila1,2, Mario Alberto Cahueque-Lemus3, Andres Enrique Cobar-Bustamante3 and Maria Cristina Bregni-Duraés4
1Spine Surgeon, Western Medical Center Hospital, Guadalajara, Jalisco, Mexico
2Faculty of Medicine professor, Mexican Institute of Social Security, TEC de Monterrey, Guadalajara, Jalisco, Mexico
3Orthopedic Surgeon, Western Medical Center Hospital, Guadalajara, Jalisco, Mexico
4Orthopedic Surgeon, Guatemalan Social Security Institute, Guatemala, Guatemala, Mexico
Corresponding Author : Jose Maria Jimenez Avila
Spine Surgeon, Western Medical Center Hospital
Faculty of Medicine Professor, Mexican Institute of Social Security
TEC de Monterrey, Guadalajara, Jalisco, Mexico
Tel: 3310704802
E-mail: [email protected]
Received: July 08, 2015 Accepted: August 11, 2015 Published: August 13, 2015
Citation: Jimenez-Avila JM, Cahueque-Lemus MA, Cobar-Bustamante AE, Bregni-Duraés MC (2015) Vertebral Destruction Syndrome: From Knowledge to Practice. J Spine 4:251.doi:10.4172/2165-7939.1000251
Copyright: © 2015 Jimenez-Avila JM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Related article at Pubmed, Scholar Google

Visit for more related articles at Journal of Spine


The term Vertebral Destruction Syndrome comprises pathologies causing structural changes in the spine in the vertebral body mainly producing mechanical deformity and neurological involvement. Among the pathologies found in this definition are infectious and metabolic tumors. The vertebral osteomyelitis is a disease that occurs mainly in adults >50 years; we speak of spondylodiscitis when condition affects the disc and vertebral body. The most important in the vertebral body is Staphylococcus aureus osteomyelitis, seen in over 50% of cases. Tumors of the spine can start from local or adjacent spinal injuries or distant spread through the blood or lymphatic. Metastases injuries account for about 97% of all tumors of the spine. Primary tumors that most commonly spread to spine is lung, prostate, breast and kidney. Metabolic bone diseases are a group of disorders that occur as a result of changes in calcium metabolism, spine contains large amounts of metabolically active cancellous bone, which must withstand axial loads during stance, and osteoporosis is a metabolic disease that most commonly affects the spine, characterized by low bone mass.

The diagnosis of these entities is important for treatment and prognosis of the patient, the term Vertebral Destruction Syndrome proposes a notarized scheme aimed at improving patient prognosis and their prompt treatment.

Vertebral destruction syndrome; Spondilydiscitis; Spinal tumors; Osteomyelitis
The term Vertebral Destruction Syndrome comprises a group of different pathologies that cause structural change in the spine, mainly in the vertebral body and resulting in mechanical and neurological consequences. Among these, are Neoplastic, Metabolic and Infectious cause’s vertebral destruction syndrome (Figure 1).
Infectious etiology
Vertebral Osteomyelitis is an estimated 5% of all bone infections. The vertebral body can be affected without the intervertebral disc being involved, due to hematogenous Spread of the disease. The most important infecting organism is Staphylococcus aureus, which is responsible for more than 50% of cases in developing countries, followed by Mycobacterium Tuberculosis rods. Other bacteria responsible for this disease are Brucella melitensis, Pseudomona aeureginosa and Candida spp.
Spondilydiscitis is recently known to be a rising type of spinal infection in the last 15 years, due to invasive diagnostic and treatment procedures that result in bacteremia and sepsis.
Neoplastic etiology
Spinal tumors can both be local or distant, arising from the hematogenous or lymphatic Spread of malignant cells. Metastatic tumors comprise 97% of all neoplastic pathology of the spine, and among the most common sites of origin are the lung, prostate gland, mammary gland and kidney [1-3].
Metastatic tumors are the most frequent type of vertebral tumors, its presentation consisting in pain in 85% of patients and other types of radicular symptoms in another 20%. Pain is characteristically of slow progression and is not related to physical activity, but is mainly of nocturnal presentation. The pain can be reproduced by causing pressure on the affected area, and the patient can report parentheses and other radicular symptoms, based on the affected spinal level [4,5].
Vertebral destruction in osteomyelitis can be similar radiographically, but the height of the vertebrae is reduced in infectious diseases, whereas in neoplastic diseases this is preserved. The differential diagnosis is important in decision making of definitive diagnosis and treatment (Table 1).
The main role of the biopsy procedure and sample is the confirmation of metastatic disease, and it is important to also rule out infectious pathology. The objective of the treatment in patients with spinal tumors is to not only to find a cure for the disease, but also provide relief of symptoms and rehabilitation of disabilities by providing stability of the spine and improving neurological function [6].
Metabolic etiology
Osteoporosis is he most frequently encountered metabolic disease, and can result in compression fractures that cause pain in the lower area of the spine, as well as kyphotic deformity. Osteomalacia is a less common disease, but can present itself in a similar manner. Paget´s Disease is an excessive bone formation which occurs in an expansive pattern resulting in compression of the dural sac and its elements. Among the metabolic causes of spinal disease, Osteoporosis is the most common, with up to a quarter of women over 65 years of age being involved. It is responsible for 1.5 million fractures in the United States each year of which 500,000 correspond to vertebral fractures; however, this is a silent disease with most of the fractures being asymptomatic [7].
Vertebral Destruction Syndrome
The Vertebral Destruction Syndrome is a disease of multiple etiologies, characterized by alterations in the anatomy of the spine, specifically deformity and size increment of the vertebral bodies adjacent to the injury, which is related to neurological and mechanical disabilities. The causes associated to the disease are infectious (bacterial and fungal), metabolic (osteoporosis) and neoplastic, (primary and metastatic) and the proposed diagnosis must be made under the correct analysis of the disease in mention [8].
“The imaging study does not result in diagnosis”
The initial approach to the patient in the emergency room begins in screening, and must be made by a cautious and detailed history, consisting in the presence of pain and its localization, history of fever, night sweats, weight loss, and certain specific details, such as consumption of non-pasteurized milk products that alerts us of potential infection with Brucella Melitensis. The clinical diagnosis can confuse the physician, just as in the case of a patient with the clinical and radiologic characteristics of a spinal Lymphoma, and the actual disease being a vertebral osteomyelitis with Bartonella Henslae infection [9,10] (Figure 2).
Imaging techniques are of importance with the history of the disease, observing loss of intervertebral height seen in bacterial infection, and the vertebral disc not being involved in mycobacterial and fungal disease.
In neoplastic disease, a single vertebral body can be involved, with evidence of collapse and pedicle involvement in the setting of metastatic disease along with sagital balance deformity, scoliosis and laterolisthesis. Anatomical structures and deformity can best be appreciated in Computed Tomographic Scans. In cases of Multiple Myeloma, magnetic resonance imaging is the method of choice in the approach of the evaluation of the spine, and gammagraphy in the scenario of metastatic injuries.
In the suspicion of neoplastic injuries of the spine, screening methods include specific serological testing. Diagnostic tests such as Bence Jones Protein, Bone Marrow Aspirate, Erythrocyte sedimentation rate and Reactive C Protein are used not only for diagnosis but also for follow up purposes [10,11].
Among the diagnostic methods to assess bone mineral density, Dual Energy X- Ray Absorption (DEXA) is a rapid and useful tool, due to its precise information for the surgeon to assess whether an implant can tolerate the axial load on an implant [12,13].
Infectious etiology
In the event of the suspicion of Vertebral Osteomyelitis, the bone biopsy and cultivation for microbiological purposes is indicated previous to the administration of antibiotic therapy. Surgery is indicated under the following circumstances [14].
Cultivation for bacteriological diagnosis
Clinically evident abscess formation (in the presence of fever)
Cases that is refractory to the previously established treatment (persisting fever, elevated Erythrocyte Sedimentation Rate and C - reactive protein)
Spinal cord involvement
Instability secondary to significant deformity or vertebral body involvement
Metabolic etiology
Osteoporosis: Osteoporosis is the most prevalent type of bone mineral deficiency in adult patients. This disease is responsible for about 1.5 million fractures per year, and in nearly half of these the vertebral bodies are involved. A third of the female population over 65 years old suffers of at least one vertebral fracture. The treatment of these patients is mainly prophylactic, with the administration of pharmacologic therapy [15].
The majority of patients with fractures due to osteoporosis are initially managed in a non-operative manner. Pain medication, rest, ortheses and physical therapy are the mainstray of treatment. Early mobilization of the patient is important, and both vertebroplasty and kyphoplasty reduce symptoms and pain in patients with compression fractures, that do not improve with non-operative treatment [16,17].
Neoplastic etiology
Tumors that result in vertebral body destruction are 95% of metastatic origin, and mainly arise from lung, prostate, mammary gland and kidney cancer [18,19].
Chemotherapy has limited use when it comes to metastatic tumors, and most patients are referred to radiotherapy treatment, with up to 80% of patients treated successfully. The combination of radiotherapy and surgical treatment is the usual method of choice, and instability and neurological impairment are the determining factors for surgical treatment [20].
Vertebral spine injuries can have a varied clinical and radiologic presentation, being of infectious, neoplastic or metabolic origin, resulting in a confusing diagnosis for the treating physician. The multiple possibilities of causes of this disease result in anatomical alterations of the spine, and are accompanied by pain and functional disability due to mechanical and neurological changes.
The diagnosis of Vertebral Destruction Syndrome comprises a series of diagnostic steps in the assessment of the patient, analyzing each in a systemized and timely fashion, addressing each of the factors that can affect the patient. Each of the etiologies that cause the syndrome to share common characteristics, which are commonly described in medical literature, but it is important to consider the singularities of each of the presenting clinical settings, to permit a systematic approach to each entity, reducing the time to diagnosis and treatment. This systematic approach to the evaluation of the patient that is proposed must take advantage of the diagnostic tools indicated for each of the before mentioned etiologies, in accordance to avoiding false positive results that may not only delay diagnosis, but affect the ideal and prompt treatment of the patient (Figure 3).

Select your language of interest to view the total content in your interested language
Post your comment

Share This Article

Article Usage

  • Total views: 15679
  • [From(publication date):
    August-2015 - Feb 26, 2020]
  • Breakdown by view type
  • HTML page views : 11767
  • PDF downloads : 3912

Review summary

  1. drbanerji
    Posted on Dec 28 2016 at 7:21 pm
    Hello I’m Bill Cliton, I want to say a very special thanks to Dr.Aknimo for helping me get cured from Cancer disease, I was almost in a state of death last month that i could not even do anything on my own without the help of someone. On a very faithful evening i was trying to check the internet for the recent news in the society when i came across a man giving his testimonies of what Dr. Aknimo has done for him and his household, so i quickly collected his mail and decided to give it a trial. I contacted him and told him of my dying state and my predicament and he sent me some medicines through DHL and instructed me on how to take them, which i did, and behold after two weeks i noticed some slight change in my body and i went to the hospital and discovered that i was cured completely now today am a living testimony. Then i said to myself that i am still going to share my own testimony so that for those who have lost all hope, kindly contact him today through his email he can help you, [email protected] Or you call him on his mobile number +2349080606667. He’s waiting to help you. Warmest Regards.

Post your comment

captcha   Reload  Can't read the image? click here to refresh
Peer Reviewed Journals

Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals